Zobrazeno 1 - 10
of 395
pro vyhledávání: '"Jens, Hansen"'
Autor:
Jens Hansen, Yuguang Xiong, Mustafa M. Siddiq, Priyanka Dhanan, Bin Hu, Bhavana Shewale, Arjun S. Yadaw, Gomathi Jayaraman, Rosa E. Tolentino, Yibang Chen, Pedro Martinez, Kristin G. Beaumont, Robert Sebra, Dusica Vidovic, Stephan C. Schürer, Joseph Goldfarb, James M. Gallo, Marc R. Birtwistle, Eric A. Sobie, Evren U. Azeloglu, Seth I. Berger, Angel Chan, Christoph Schaniel, Nicole C. Dubois, Ravi Iyengar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardiom
Externí odkaz:
https://doaj.org/article/5c705931ae3749d8b0d5c464d5e8d788
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Cell level functions underlie tissue and organ physiology. Gene expression patterns offer extensive views of the pathways and processes within and between cells. Single cell transcriptomics provides detailed information on gene expression within cell
Externí odkaz:
https://doaj.org/article/96a31126284142d295c95c546094b0dd
Autor:
Carlos A. Toro, Jens Hansen, Mustafa M. Siddiq, Kaitlin Johnson, Jiqing Cao, Adriana Pero, Ravi Iyengar, Dongming Cai, Christopher P. Cardozo
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 464-477 (2023)
Apolipoprotein E epsilon 4 (ApoE4) is the second most common variant of ApoE, being present in ?14% of the population. Clinical reports identify ApoE4 as a genetic risk factor for poor outcomes after traumatic spinal cord injury (SCI) and spinal cord
Externí odkaz:
https://doaj.org/article/a46325a807ea45b8958cf91d5ccc95f7
Autor:
Kumar Sharma, Guanshi Zhang, Jens Hansen, Petter Bjornstad, Hak Joo Lee, Rajasree Menon, Leila Hejazi, Jian-Jun Liu, Anthony Franzone, Helen C. Looker, Byeong Yeob Choi, Roman Fernandez, Manjeri A. Venkatachalam, Luxcia Kugathasan, Vikas S. Sridhar, Loki Natarajan, Jing Zhang, Varun S. Sharma, Brian Kwan, Sushrut S. Waikar, Jonathan Himmelfarb, Katherine R. Tuttle, Bryan Kestenbaum, Tobias Fuhrer, Harold I. Feldman, Ian H. de Boer, Fabio C. Tucci, John Sedor, Hiddo Lambers Heerspink, Jennifer Schaub, Edgar A. Otto, Jeffrey B. Hodgin, Matthias Kretzler, Christopher R. Anderton, Theodore Alexandrov, David Cherney, Su Chi Lim, Robert G. Nelson, Jonathan Gelfond, Ravi Iyengar, for the Kidney Precision Medicine Project
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Diabetic kidney disease (DKD) can lead to end-stage kidney disease (ESKD) and mortality; however, few mechanistic biomarkers are available for high-risk patients, especially those without macroalbuminuria. Urine from participants with diabetes from t
Externí odkaz:
https://doaj.org/article/15a3cc7202a34114a72f51162fa19310
Autor:
Mustafa M. Siddiq, Nicholas P. Johnson, Yana Zorina, Arjun Singh Yadaw, Carlos A. Toro, Jens Hansen, Vera Rabinovich, Sarah M. Gregorich, Yuguang Xiong, Rosa E. Tolentino, Sari S. Hannila, Ehud Kaplan, Robert D. Blitzer, Marie T. Filbin, Christopher P. Cardozo, Christopher L. Passaglia, Ravi Iyengar
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination th
Externí odkaz:
https://doaj.org/article/bc2b4a9dfdb640d18ca703e4fcaa209f
Autor:
Mustafa M. Siddiq, Carlos A. Toro, Nicholas P. Johnson, Jens Hansen, Yuguang Xiong, Wilfredo Mellado, Rosa E. Tolentino, Kaitlin Johnson, Gomathi Jayaraman, Zaara Suhail, Lauren Harlow, Jinye Dai, Kristin G. Beaumont, Robert Sebra, Dianna E. Willis, Christopher P. Cardozo, Ravi Iyengar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionNeurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), de novo translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs that participate in neurore
Externí odkaz:
https://doaj.org/article/e7907528427c4cc4850262c458caa737
Autor:
Carlos A. Toro, Kaitlin Johnson, Jens Hansen, Mustafa M. Siddiq, Walter Vásquez, Wei Zhao, Zachary A. Graham, Juan C. Sáez, Ravi Iyengar, Christopher P. Cardozo
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Membrane channels such as those formed by connexins (Cx) and P2X7 receptors (P2X7R) are permeable to calcium ions and other small molecules such as adenosine triphosphate (ATP) and glutamate. Release of ATP and glutamate through these channels is a k
Externí odkaz:
https://doaj.org/article/fd2e2acef525478a926bf42909a3ebbd
Autor:
Yifei Sun, Keiichi Asano, Lauriane Sedes, Anna Cantalupo, Jens Hansen, Ravi Iyengar, Martin J. Walsh, Francesco Ramirez
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
To improve our limited understanding of the pathogenesis of thoracic aortic aneurysm (TAA) that leads to acute aortic dissection, single-cell RNA sequencing (scRNA-seq) was employed to profile disease-relevant transcriptomic changes of aortic cell po
Externí odkaz:
https://doaj.org/article/d24fa62ce763489b9e21a6996b4faee9
Autor:
Yuguang Xiong, Tong Liu, Tong Chen, Jens Hansen, Bin Hu, Yibang Chen, Gomathi Jayaraman, Stephan Schürer, Dusica Vidovic, Joseph Goldfarb, Eric A. Sobie, Marc R. Birtwistle, Ravi Iyengar, Hong Li, Evren U. Azeloglu
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-11 (2022)
Measurement(s) protein expression profiling Technology Type(s) mass spectrometry assay Factor Type(s) Individual proteome • Kinase inhibitors Sample Characteristic - Organism Homo sapiens Machine-accessible metadata file describing the reported dat
Externí odkaz:
https://doaj.org/article/3417c9ff341948ffb259c8e4c42eb730
Autor:
J. G. Coen van Hasselt, Rayees Rahman, Jens Hansen, Alan Stern, Jaehee V. Shim, Yuguang Xiong, Amanda Pickard, Gomathi Jayaraman, Bin Hu, Milind Mahajan, James M. Gallo, Joseph Goldfarb, Eric A. Sobie, Marc R. Birtwistle, Avner Schlessinger, Evren U. Azeloglu, Ravi Iyengar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cardiotoxic adverse events associated with kinase inhibitors are a growing concern in clinical oncology. Here the authors use cellular transcriptomic responses of human cardiomyocytes treated with protein kinase inhibitors and the associated drug str
Externí odkaz:
https://doaj.org/article/86f9cff8a37243ebb6125f4c841c6732