Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jens, Gruber"'
Autor:
July Constanza Buitrago, Sarah L. Morris, Astrid Backhaus, Gesa Kaltenecker, Jagan Mohan Kaipa, Cyrille Girard, Stefan Schneider, Jens Gruber
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Induced pluripotent stem cell (iPSC)-derived mesenchymal stromal cells (iMSCs) offer a promising alternative to primary mesenchymal stromal cells (MSCs) and their derivatives, particularly extracellular vesicles (EVs), for use in advanced th
Externí odkaz:
https://doaj.org/article/205e2a97979849688a60c665a5ad8867
Autor:
Judith K. Keller, Alex Dulovic, Jens Gruber, Johanna Griesbaum, Nicole Schneiderhan-Marra, Clemens Wülfing, Jana Kruse, Annika Hartmann, Esther K. Diekhof
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Secretory immunoglobulin A (sIgA) in saliva is the most important immunoglobulin fighting pathogens in the respiratory tract and may thus play a role in preventing SARS-CoV-2 infections. To gain a better understanding of the plasticity in th
Externí odkaz:
https://doaj.org/article/2f59591598714c75a832f04fab1b6ef5
Autor:
Nathalie Verónica Fernández Villalobos, Patrick Marsall, Johanna Carolina Torres Páez, Julia Strömpl, Jens Gruber, Martín Lotto Batista, Daria Pohl, Gustavo Concha, Hagen Frickmann, Fernando Pio de la Hoz Restrepo, Nicole Schneiderhan-Marra, Gérard Krause, Alex Dulovic, Monika Strengert, Simone Kann
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-8 (2023)
Abstract Background Although anti-SARS-CoV-2 humoral immune responses and epidemiology have been extensively studied, data gaps remain for certain populations such as indigenous people or children especially in low- and middle-income countries. To ad
Externí odkaz:
https://doaj.org/article/d90bfb0b882741b1bb98ce5a71eedb75
Autor:
Matthias Becker, Anne Cossmann, Karsten Lürken, Daniel Junker, Jens Gruber, Jennifer Juengling, Gema Morillas Ramos, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gérard Krause, Nicole Schneiderhan-Marra, Monika Strengert, Alex Dulovic, Georg M. N. Behrens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Haemodialysis patients respond poorly to vaccination and continue to be at-risk for severe COVID-19. Therefore, dialysis patients were among the first for which a fourth COVID-19 vaccination was recommended. However, targeted information on how to be
Externí odkaz:
https://doaj.org/article/c3c8a3ec127e47309ad52458e675fb17
Autor:
Monika Strengert, Matthias Becker, Gema Morillas Ramos, Alex Dulovic, Jens Gruber, Jennifer Juengling, Karsten Lürken, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Anne Cossmann, Metodi V. Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gérard Krause, Nicole Schneiderhan-Marra, Georg M.N. Behrens
Publikováno v:
EBioMedicine, Vol 70, Iss , Pp 103524- (2021)
Background: Patients with chronic renal insufficiency on maintenance haemodialysis face an increased risk of COVID-19 induced mortality and impaired vaccine responses. To date, only a few studies have addressed SARS-CoV-2 vaccine elicited immunity in
Externí odkaz:
https://doaj.org/article/dcb1f42c74f2458e8212c1eaf18c16e4
Autor:
Mónica Cruz-Barrera, Nathalia Flórez-Zapata, Nicolás Lemus-Diaz, Carlos Medina, Cristian-Camilo Galindo, Lorena-Xiomara González-Acero, Luz Correa, Bernardo Camacho, Jens Gruber, Gustavo Salguero
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Mesenchymal stromal cells (MSC) have been used in over 800 clinical trials with encouraging results in the field of transplant medicine and chronic inflammatory diseases. Today, Umbilical Cord (UC)-derived MSC are the second leading source used for c
Externí odkaz:
https://doaj.org/article/69605a4a097b4505b68f7c1eacfff978
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
Autor:
Anthea Di Rita, Angelo Peschiaroli, Pasquale D′Acunzo, Daniela Strobbe, Zehan Hu, Jens Gruber, Mads Nygaard, Matteo Lambrughi, Gerry Melino, Elena Papaleo, Jörn Dengjel, Said El Alaoui, Michelangelo Campanella, Volker Dötsch, Vladimir V. Rogov, Flavie Strappazzon, Francesco Cecconi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Mitophagy is crucial for mitochondrial quality control and maintenance of cellular homeostasis. Here the authors identify an E3 ubiquitin ligase, HUWE1, that collaborates with LC3-interacting protein AMBRA1 to induce mitochondrial clearance.
Externí odkaz:
https://doaj.org/article/ef54c1bc371f46c7a0abb9f445a40480
Autor:
Daniel B. Hoffmann, Jens Gruber, Kai O. Böker, Delia Deppe, Stephan Sehmisch, Arndt F. Schilling, Nicolas Lemus-Diaz, Marina Komrakova, Stefan Schneider
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 443-452 (2018)
Rebalancing of the RANKL/OPG system seems to be an effective treatment strategy in postmenopausal osteoporosis. Here, we evaluate the knockdown of RANKL by in-vivo-delivered siRNA in a rat model of osteoporosis. Virus-like-particles (VLPs) derived fr
Externí odkaz:
https://doaj.org/article/b2670b6e41a94cd28c247725f8d7e110
Autor:
Lara Timantra Schiller, Nicolás Lemus-Diaz, Rafael Rinaldi Ferreira, Kai Oliver Böker, Jens Gruber
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 278-287 (2018)
Research on cell-free vesicles revealed a multitude of characteristics, in particular of microvesicles and exosomes, that range from their potential as biomarkers to a function in horizontal transfer of genetic information from cell to cell and also
Externí odkaz:
https://doaj.org/article/daa402c36ffc42858b330662e25c760d
Publikováno v:
Bio-Protocol, Vol 8, Iss 17 (2018)
MicroRNA-induced gene regulation is a growing field in basic and translational research. Examining this regulation directly in cells is necessary to validate high-throughput data originated from RNA sequencing technologies. For this several studies e
Externí odkaz:
https://doaj.org/article/56520bb23180447f9d206cc400c3e5f9