Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jeno M Scharer"'
Publikováno v:
Songklanakarin Journal of Science and Technology (SJST), Vol 27, Iss 5, Pp 1057-1064 (2005)
The fed-batch optimization of penicillin productivity was applied as an example of optimization algorithm verification. The objective function of this problem was to optimize penicillin productivity by determination of feed rate trajectory. This stud
Externí odkaz:
https://doaj.org/article/bb53d239c01142f680cc7ed4c1855ec0
Publikováno v:
Biochemical Engineering Journal. 88:154-161
Disposable rocking bioreactors (RBs) are widely employed for cultivation of recombinant mammalian and insect cell lines, although the perception of inadequate mass transfer has prevented their application to bioprocesses based on microbial platforms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1c175a1d22b881a1dd949011247ff15
https://doi.org/10.1016/j.bej.2014.04.011
https://doi.org/10.1016/j.bej.2014.04.011
Autor:
Brian Ingalls, Jeno M. Scharer, Hector Budman, Brendan J. McConkey, Saeideh Naderi, Mukesh Meshram
Publikováno v:
Metabolic Engineering. 19:57-68
The regulation of metabolism in mammalian cell culture is closely linked to the process of apoptosis-programmed cell death. Apoptosis negatively impacts culture viability, product yield, and quality. An improved understanding of the interaction betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ddba28c8247beba1fca79ae979a331
https://doi.org/10.1016/j.ymben.2013.06.002
https://doi.org/10.1016/j.ymben.2013.06.002
Autor:
Shing-Yi Suen, C. Howie Honeyman, Drew Fenner, Valerie Orr, C. Perry Chou, Lisa Crossley, Jeno M. Scharer, Murray Moo-Young
Publikováno v:
Journal of Chromatography B. 900:71-78
Downstream purification often represents the most cost-intensive step in the manufacturing of recombinant proteins since conventional purification processes are lengthy, technically complicated, and time-consuming. To address this issue, herein we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b0cc3256f760ace5daafea0e0356a0
https://doi.org/10.1016/j.jchromb.2012.05.039
https://doi.org/10.1016/j.jchromb.2012.05.039
Autor:
Shing-Yi Suen, C. Perry Chou, C. Howie Honeyman, Murray Moo-Young, Drew Fenner, Jeno M. Scharer, Kajan Srirangan, Luyang Zhong, Lisa Crossley
Publikováno v:
Separation and Purification Technology. 83:121-129
A novel, RNase-free, and potentially scalable bioprocess was developed for the production of pharmaceutical-grade plasmid DNA. High bioprocess recovery and product quality were primarily associated with the optimal integration of impurity removal by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaecc89d264bc0eb34c9b63ec0594a19
https://doi.org/10.1016/j.seppur.2011.09.024
https://doi.org/10.1016/j.seppur.2011.09.024
Proteomics analysis of chinese hamster ovary cells undergoing apoptosis during prolonged cultivation
Autor:
Brian Ingalls, Yi-Yun C. Wei, Brendan J. McConkey, Saeideh Naderi, Mukesh Meshram, Jeno M. Scharer, Hector Budman
Publikováno v:
Cytotechnology. 63:663-677
The degradation of environmental conditions, such as nutrient depletion and accumulation of toxic waste products over time, often lead to premature apoptotic cell death in mammalian cell cultures and suboptimal protein yield. Although apoptosis has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038a740f1587340b8caebff30499d40e
https://doi.org/10.1007/s10616-011-9385-2
https://doi.org/10.1007/s10616-011-9385-2
Autor:
Brendan J. McConkey, Saeideh Naderi, Jeno M. Scharer, Mukesh Meshram, Brian Ingalls, Catherine Wei, Hector Budman
Publikováno v:
Biotechnology Progress. 27:1197-1205
A metabolic flux based methodology was developed for modeling the metabolism of a Chinese hamster ovary cell line. The elimination of insignificant fluxes resulted in a simplified metabolic network which was the basis for modeling the significant met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210026a0b53d1376cf2f536ec9b282b7
https://doi.org/10.1002/btpr.647
https://doi.org/10.1002/btpr.647
Publikováno v:
The Canadian Journal of Chemical Engineering. 89:879-888
A metabolic reaction network including carbohydrate and amino acid metabolism in both anabolic and catabolic reactions was developed for Streptomyces lividans. Based on observed nutrient consumption, the fermentation process comprised two stages: ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7580182ca4d0b48d92fa796b366a8589
https://doi.org/10.1002/cjce.20447
https://doi.org/10.1002/cjce.20447
Autor:
Brendan J. McConkey, Brian Ingalls, Yi-Yun Catherine Wei, Hector Budman, Jeno M. Scharer, Mukesh Meshram, Saeideh Naderi
Publikováno v:
IFAC Proceedings Volumes. 44:9691-9696
Caspases are the key mediators of the apoptotic cascade leading to cell death in mammalian cells. Caspase activation in a Chinese Hamster Ovary (CHO) cell line producing Anti-RhD monoclonal antibody (mAb) in batch culture was simulated and measured e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41229c3ac8788a24c7aa9de479c88cf4
https://doi.org/10.3182/20110828-6-it-1002.02462
https://doi.org/10.3182/20110828-6-it-1002.02462
Autor:
Brendan J. McConkey, Hector Budman, Brian Ingalls, Yi-Yun Catherine Wei, Jeno M. Scharer, Mukesh Meshram, Saeideh Naderi
Publikováno v:
IFAC Proceedings Volumes. 43:467-472
Caspases play important roles in driving the progression of apoptosis. We developed a first principle-based population-balance model to predict the time-evolution of caspase activities in a cell culture process under different cell density conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30c854579dcc2b847fb05ecf161b85ba
https://doi.org/10.3182/20100707-3-be-2012.0026
https://doi.org/10.3182/20100707-3-be-2012.0026