Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jenny Ying-Lin Lu"'
Autor:
Daniel C-H Lin, Jane Zhang, Run Zhuang, Frank Li, Kathy Nguyen, Michael Chen, Thanhvien Tran, Edwin Lopez, Jenny Ying Lin Lu, Xiaoyan Nina Li, Liang Tang, George R Tonn, Gayathri Swaminath, Jeff D Reagan, Jin-Long Chen, Hui Tian, Yi-Jyun Lin, Jonathan B Houze, Jian Luo
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27270 (2011)
Agonists of GPR40 (FFA1) have been proposed as a means to treat type 2 diabetes. Through lead optimization of a high throughput screening hit, we have identified a novel GPR40 agonist called AMG 837. The objective of these studies was to understand t
Externí odkaz:
https://doaj.org/article/729ea24e76304c709713d2c9927fb903
Autor:
Cory S. Wagg, Jeff D. Reagan, John R. Ussher, Liyan Zhang, Kenneth Milner, Dongming M. Liu, Angela Fu, Alykhan Motani, Abhishek Gupta, Osama Abo Alrob, Chaves Mary, Nikole J. Byrne, Natasha Fillmore, Pavan K. Battiprolu, Arata Fukushima, Shaohua Wang, Gary D. Lopaschuk, Khanh Nguyen, Wei Wang, Jun Mori, Tariq R. Altamimi, Jenny Ying-Lin Lu, Jason R.B. Dyck
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 385-400 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 385-400 (2019)
Visual Abstract
Highlights • MCD inhibition decreases fatty acid oxidation via increasing malonyl coenzyme A levels to prevent fatty acid uptake into mitochondria in the failing hearts induced by coronary artery ligation. • Downregulating fa
Highlights • MCD inhibition decreases fatty acid oxidation via increasing malonyl coenzyme A levels to prevent fatty acid uptake into mitochondria in the failing hearts induced by coronary artery ligation. • Downregulating fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074f5ff29e2376a91baabc9d38b612d8
https://pubmed.ncbi.nlm.nih.gov/31312761
https://pubmed.ncbi.nlm.nih.gov/31312761
Autor:
Pierre Deprez, Paul M. Wehn, Jeff D. Reagan, Minghan Wang, Paul E. Harrington, Mark P. Grillo, Kanaka Pattabiraman, James Davis, Charles Henley, Sean Morony, Taoues Temal, Christopher H. Fotsch, Steve F. Poon, Timothy J. Carlson, David J. St. Jean, Sarah E. Lively, Yuhua Yang, Jenny Ying-Lin Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6625-6628
A series of urea based calcimimetics was optimized for potency and oral bioavailability. Crucial to this process was overcoming the poor pharmacokinetic properties of lead thiazole 1. Metabolism-guided modifications, characterized by the use of metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864b86539d0406f1c17b250323d10011
https://doi.org/10.1016/j.bmcl.2013.10.050
https://doi.org/10.1016/j.bmcl.2013.10.050
Autor:
Jenny Ying-Lin Lu, Jonathan B. Houze, Rajiv Sharma, Michael J. Schmitt, Jeff D. Reagan, Kathy Nguyen, Hui Tian, Ying Sun, Jinqian Liu, Yang Li, Daniel C.-H. Lin, Liang Tang, Wei Qiu, Michael Chen, Steven J. Shuttleworth, Yingcai Wang, Alex Zhang, George Tonn, Edwin Lopez, Jiwen Liu, Michelle Akerman, Julio C. Medina, Liusheng Zhu, Jian Luo, Jane Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1267-1270
The discovery that certain long chain fatty acids potentiate glucose stimulated insulin secretion through the previously orphan receptor GPR40 sparked interest in GPR40 agonists as potential antidiabetic agents. Optimization of a series of β-substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf658a372d0b395d425e7df4ade3df1
https://doi.org/10.1016/j.bmcl.2011.10.118
https://doi.org/10.1016/j.bmcl.2011.10.118
Autor:
William G. Richards, Jeff D. Reagan, Edward Shatzen, Monica Florio, Charles Henley, David J. St. Jean, Jenny Ying-Lin Lu, James W. Davis, Yuhua Yang, Christopher H. Fotsch, James Pretorius, Wei Fan, Sean Morony, Banghua Sun
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:681-691
Calcimimetics are positive allosteric modulators to the calcium-sensing receptor (CaSR). Activation of the CaSR inhibits the secretion of parathyroid hormone (PTH), stimulates the secretion of calcitonin, and decreases serum calcium (Ca(2+)). Cinacal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385bca994d6f67b93548f4120256f3b4
https://doi.org/10.1124/jpet.110.178681
https://doi.org/10.1124/jpet.110.178681
Autor:
Yuhua Yang, Adam Davenport, Michael G. Kelly, Andrew Tasker, Michael Croghan, Guomin Yao, Fred D. Lott, Jeff D. Reagan, Christopher H. Fotsch, James Davis, Minghan Wang, Chiara Ghiron, Steve F. Poon, Qingping Zeng, David Martin, Elena Portero-Larragueta, Thomas Stephen Coulter, David J. St. Jean, Jonathan Hutchinson, Charles Henley, Kelly Regal, Paul E. Harrington, Sean Morony, Jeffrey Clarine, Jenny Ying-Lin Lu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5544-5547
The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e863f669015b2935d346cb0793aca12e
https://doi.org/10.1016/j.bmcl.2010.07.060
https://doi.org/10.1016/j.bmcl.2010.07.060
Autor:
Jeff D. Reagan, Shamin Summer, Yuhua Yang, Jenny Ying-Lin Lu, Christiaan J. M. Saris, John Whoriskey, Xiaosu Wu
Publikováno v:
Pharmacology. 86:1-5
We report that the asthma drugs cromolyn disodium and nedocromil sodium are potent G-protein-coupled receptor 35 (GPR35) agonists. We utilized calcium flux and inositol phosphate accumulation assays to examine the pharmacology of these asthma drugs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0e04967067ca13a28c4420ced0c3fd
https://doi.org/10.1159/000314164
https://doi.org/10.1159/000314164
Autor:
Jenny Ying-Lin Lu, Lily Liu, Helene Baribault, Heather Salomonis, Qiong Cao, Jonathan B. Houze, Franziska Steger, Yumei Xiong, Jane Zhang, Daniel C.-H. Lin, Lynn Miao, Suzanne Coberly, Gayathri Swaminath, Yingcai Wang, Li Yang, Qi Guo, Margrit Schwarz, Simon Wong, Paul John Dransfield, Jiwen Jim Liu, Ralf Schwandner
Publikováno v:
Molecular and cellular endocrinology. 369(1-2)
FFA1 (GPR40) and GPR120 are G-protein-coupled receptors activated by long-chain fatty acids. FFA1 is expressed in pancreatic β-cells, where it regulates glucose-dependent insulin secretion, and GPR120 has been implicated in mediating GLP-1 secretion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db173ad7b0bee86921a7a19cb2e99900
https://pubmed.ncbi.nlm.nih.gov/23403053
https://pubmed.ncbi.nlm.nih.gov/23403053
Autor:
Run Zhuang, Liang Tang, Daniel C.-H. Lin, Hui Tian, Edwin Lopez, Jane Zhang, Jeff D. Reagan, Xiaoyan Nina Li, Jonathan B. Houze, Jian Luo, George Tonn, Jenny Ying-Lin Lu, Kathy Nguyen, Jin-Long Chen, Gayathri Swaminath, Yi-Jyun Lin, Thanhvien Tran, Frank Li, Michael Chen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 11, p e27270 (2011)
PLoS ONE, Vol 6, Iss 11, p e27270 (2011)
Agonists of GPR40 (FFA1) have been proposed as a means to treat type 2 diabetes. Through lead optimization of a high throughput screening hit, we have identified a novel GPR40 agonist called AMG 837. The objective of these studies was to understand t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7779db3fcf91c483f4cdcdbf32f413ce
https://pubmed.ncbi.nlm.nih.gov/22087278
https://pubmed.ncbi.nlm.nih.gov/22087278
Autor:
Yuhua Yang, Steve F. Poon, Jeff D. Reagan, David J. St. Jean, Fred D. Lott, Charles Henley, Jenny Ying-Lin Lu, James Davis, Paul E. Harrington, Christopher H. Fotsch, Sean Morony
Publikováno v:
Journal of medicinal chemistry. 52(21)
Our efforts to discover potent, orally bioavailable type II calcimimetic agents for the treatment of secondary hyperparathyroidism focused on the development of ring constrained analogues of the known calcimimetic R-568. The structure-activity relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9f6898ca381a10c9ccf357ab442ca9
https://pubmed.ncbi.nlm.nih.gov/19835382
https://pubmed.ncbi.nlm.nih.gov/19835382