Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jenny Worthington"'
Autor:
Emenike Kenechi Onyido, David James, Jezabel Garcia-Parra, John Sinfield, Anna Moberg, Zoe Coombes, Jenny Worthington, Nicole Williams, Lewis Webb Francis, Robert Steven Conlan, Deyarina Gonzalez
Publikováno v:
Antibodies, Vol 12, Iss 4, p 65 (2023)
Antibody–drug conjugates (ADCs) constitute a rapidly expanding category of biopharmaceuticals that are reshaping the landscape of targeted chemotherapy. The meticulous process of selecting therapeutic targets, aided by specific monoclonal antibodie
Externí odkaz:
https://doaj.org/article/0455159f0c934ce0917b6edce050c3cc
Autor:
David Howard, David James, Jezabel Garcia-Parra, Belen Pan-Castillo, Jenny Worthington, Nicole Williams, Zoe Coombes, Sophie Colleen Rees, Kerryn Lutchman-Singh, Lewis W. Francis, Paul Rees, Lavinia Margarit, R. Steven Conlan, Deyarina Gonzalez
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundOvarian cancer (OC) is amongst the most lethal of common cancers in women. Lacking in specific symptoms in the early stages, OC is predominantly diagnosed late when the disease has undergone metastatic spread and chemotherapy is relied on t
Externí odkaz:
https://doaj.org/article/be94b6891aff4b9ea06c5d408968e40c
Autor:
Ahmed A. Ahmed, William Greenhalf, Daniel H. Palmer, Nicole Williams, Jenny Worthington, Tariq Arshad, Shozeb Haider, Effrosyni Alexandrou, Dilek Guneri, Zoe A. E. Waller, Stephen Neidle
Publikováno v:
Molecules, Vol 28, Iss 6, p 2452 (2023)
The naphthalene diimide compound QN-302, designed to bind to G-quadruplex DNA sequences within the promoter regions of cancer-related genes, has high anti-proliferative activity in pancreatic cancer cell lines and anti-tumor activity in several exper
Externí odkaz:
https://doaj.org/article/591626fbac0d4eabb244b440fd15c9c6
Autor:
Stella Irungu, Dimitrios Mavrelos, Jenny Worthington, Oleg Blyuss, Ertan Saridogan, John F. Timms
Publikováno v:
Clinical Proteomics, Vol 16, Iss 1, Pp 1-16 (2019)
Abstract Background Endometriosis is a common gynaecological disorder affecting 5–10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing patients to potential
Externí odkaz:
https://doaj.org/article/e931bed01bb64d7abb83d8872cc71e97
Autor:
Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphoryl
Externí odkaz:
https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
Autor:
Anita Yakkundi, Lynn McCallum, Anthony O'Kane, Hayder Dyer, Jenny Worthington, Hayley D McKeen, Lana McClements, Christopher Elliott, Helen O McCarthy, David G Hirst, Tracy Robson
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55075 (2013)
FK506 binding protein-like (FKBPL) and its peptide derivatives exert potent anti-angiogenic activity in vitro and in vivo and control tumour growth in xenograft models, when administered exogenously. However, the role of endogenous FKBPL in angiogene
Externí odkaz:
https://doaj.org/article/39619113e6cb4db6bf904cb99dc814a6
Autor:
Jonathan Silvertown, Laurence Cook, Robert Cameron, Mike Dodd, Kevin McConway, Jenny Worthington, Peter Skelton, Christian Anton, Oliver Bossdorf, Bruno Baur, Menno Schilthuizen, Benoît Fontaine, Helmut Sattmann, Giorgio Bertorelle, Maria Correia, Cristina Oliveira, Beata Pokryszko, Małgorzata Ożgo, Arturs Stalažs, Eoin Gill, Üllar Rammul, Péter Sólymos, Zoltan Féher, Xavier Juan
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18927 (2011)
Organisms provide some of the most sensitive indicators of climate change and evolutionary responses are becoming apparent in species with short generation times. Large datasets on genetic polymorphism that can provide an historical benchmark against
Externí odkaz:
https://doaj.org/article/3263f27ea6dd48a9b4366cf16bcbfde2
Discovery of Targets for Immune–Metabolic Antitumor Drugs Identifies Estrogen-Related Receptor Alpha
Autor:
Avinash Sahu, Xiaoman Wang, Phillip Munson, Jan P.G. Klomp, Xiaoqing Wang, Shengqing Stan Gu, Ya Han, Gege Qian, Phillip Nicol, Zexian Zeng, Chenfei Wang, Collin Tokheim, Wubing Zhang, Jingxin Fu, Jin Wang, Nishanth Ulhas Nair, Joost A.P. Rens, Meriem Bourajjaj, Bas Jansen, Inge Leenders, Jaap Lemmers, Mark Musters, Sanne van Zanten, Laura van Zelst, Jenny Worthington, Jun S. Liu, Dejan Juric, Clifford A. Meyer, Arthur Oubrie, X. Shirley Liu, David E. Fisher, Keith T. Flaherty
Publikováno v:
Cancer Discovery. 13:672-701
Drugs that kill tumors through multiple mechanisms have the potential for broad clinical benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer cell–specific regulators that simultaneously modulate tumor immu
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Machine learning evaluation of immune-metabolic targets in predicting patient response to anti-PD1 and anti-CTLA4 combination therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8bd2ff895e83091c44926de41c53a8
https://doi.org/10.1158/2159-8290.22543017
https://doi.org/10.1158/2159-8290.22543017
Autor:
Keith T. Flaherty, David E. Fisher, X. Shirley Liu, Arthur Oubrie, Clifford A. Meyer, Dejan Juric, Jun S. Liu, Jenny Worthington, Laura van Zelst, Sanne van Zanten, Mark Musters, Jaap Lemmers, Inge Leenders, Bas Jansen, Meriem Bourajjaj, Joost A.P. Rens, Nishanth Ulhas Nair, Jin Wang, Jingxin Fu, Wubing Zhang, Collin Tokheim, Chenfei Wang, Zexian Zeng, Phillip Nicol, Gege Qian, Ya Han, Shengqing Stan Gu, Xiaoqing Wang, Jan P.G. Klomp, Phillip Munson, Xiaoman Wang, Avinash Sahu
Drugs that kill tumors through multiple mechanisms have the potential for broad clinical benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer cell–specific regulators that simultaneously modulate tumor immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84488520c99a3a21d3b5183ab7ba888e
https://doi.org/10.1158/2159-8290.c.6550104.v1
https://doi.org/10.1158/2159-8290.c.6550104.v1