Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jenny Viklund"'
Autor:
Yasmin Yu, Madhumita Bogdan, Muhammad Zaeem Noman, Santiago Parpal, Elisabetta Bartolini, Kris Van Moer, Simone Caroline Kleinendorst, Kristine Bilgrav Saether, Lionel Trésaugues, Camilla Silvander, Johan Lindström, Jodi Simeon, Mary Jane Timson, Hikmat Al‐Hashimi, Bryan D. Smith, Daniel L. Flynn, Andrey Alexeyenko, Jenny Viklund, Martin Andersson, Jessica Martinsson, Katja Pokrovskaja Tamm, Angelo De Milito, Bassam Janji
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1904-1922 (2024)
An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting 34 (VPS34), a crucial lipid kinase
Externí odkaz:
https://doaj.org/article/9dddee620d924c2eb795ae4895e7f6b3
Autor:
Anton Lindberg, Emily Murrell, Junchao Tong, N. Scott Mason, Daniel Sohn, Johan Sandell, Peter Ström, Jeffrey S. Stehouwer, Brian J. Lopresti, Jenny Viklund, Samuel Svensson, Chester A. Mathis, Neil Vasdev
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is helping to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmaceutical has been optimized for
Externí odkaz:
https://doaj.org/article/565281a593e843aeae917584e9015b15
Autor:
Yasmin Yu, Muhammad Z. Noman, Santiago Parpal, Simone C. Kleinendorst, Kristine B. Saether, Andrey Alexeyenko, Jenny Viklund, Martin Andersson, Jessica Martinsson, Katja P. Tamm, Angelo De Milito, Bassam Janji
Publikováno v:
Cancer Research. 82:2116-2116
Novel approaches to reduce tumor immunosuppression and improve responses to anti-cancer immunotherapies based on immune-checkpoint inhibitors are needed. Emerging evidence demonstrates that autophagy inhibition enhances anti-tumor immunity by tumor c
Autor:
Muhammad Zaeem Noman, Angelo De Milito, Meriem Hasmim, Martin Andersson, Ravi K. Amaravadi, Malina Xiao, Yasmin Yu, Jenny Viklund, Guy Berchem, Santiago Parpal, Kris Van Moer, Jessica Martinsson, Bassam Janji
Publikováno v:
Science Advances. 6
One of the major challenges limiting the efficacy of anti–PD-1/PD-L1 therapy in nonresponding patients is the failure of T cells to penetrate the tumor microenvironment. We showed that genetic or pharmacological inhibition of Vps34 kinase activity
Autor:
Jenny Viklund, Martin Andersson, Ashley Eheim, Johan Lindström, Maria Quanz, Ulrika Ericsson, Ellermann Manuel, Andrea Glasauer, Benjamin Bader, Judith Guenther, Jörg Weiske, Katrin Nowak-Reppel, Nina Queisser, Camilla Silvander, Stefanie Bunse, Anja Giese, Tobias Ginman, Rickard Forsblom, Horst Irlbacher, Lionel Trésaugues, Hanna Meyer, Marcus Bauser, Andrea Haegebarth, Roland Neuhaus, Mátyás Gorjánácz, F. Rahm
Publikováno v:
'ACS Chemical Biology ', vol: 12, pages: 1986-1992 (2017)
MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates to prevent their incorporation into replicating DNA. Early tool compounds published in the literature inhibited the enzymatic activity of MTH1 and subsequent
Autor:
Jenny Viklund, Matheus Dyczynski, Henric Zazzi, Mikael Lerner, Katja Pokrovskaja Tamm, Tiago Braga, Angelo De Milito, Aine Brigette Henley, Magdalena Otrocka, Krister Wennerberg, Yasmin Yu, Santiago Parpal, Jessica Martinsson, Dan Grandér
Resistance to chemotherapy is a challenging problem for treatment of cancer patients and autophagy has been shown to mediate development of resistance. In this study we systematically screened a library of 306 known anti-cancer drugs for their abilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408bc40ab04c91f0f31b34489b6c6cc8
http://hdl.handle.net/10138/238349
http://hdl.handle.net/10138/238349
Autor:
Lionel Trésaugues, Kilian Huber, Ioanna Panagakou, Camilla Silvander, F. Rahm, Martin Andersson, Antoine Talagas, Oleg Fedorov, Marcus Bauser, Tobias Ginman, L. Diaz-Saez, Ellermann Manuel, Kenth Hallberg, Rickard Forsblom, Johan Lindström, Mátyás Gorjánácz, Anja Giese, Judith Günther, Lars Boukharta Persson, P. Siejka, Jenny Viklund, Ulrika Ericsson
Publikováno v:
Journal of Medicinal Chemistry. 61(6)
Recent literature has both suggested and questioned MTH1 as a novel cancer target. BAY-707 was just published as a target validation small molecule probe for assessing the effects of pharmacological inhibition of MTH1 on tumor cell survival, both in
Publikováno v:
Current Medicinal Chemistry. 24
Drug resistance and therapeutic failure are important causes of disease relapse and progression and may be considered as major obstacles preventing cure of cancer patients. Tumors use a large number of molecular, biochemical and cellular mechanisms t
Autor:
Britt-Marie Swahn, Ylva Gravenfors, Gunnar Nordvall, Jenny Viklund, Fredrik Rahm, Karin Kolmodin, Mats Svensson
Publikováno v:
ACS Medicinal Chemistry Letters. 5:440-445
In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer's disease. De novo design of core fragme
Publikováno v:
Seminars in cancer biology. 43
Interstitial acidification is a hallmark of solid tumor tissues resulting from the combination of different factors, including cellular buffering systems, defective tissue perfusion and high rates of cellular metabolism. Besides contributing to tumor