Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jenny V. Le"'
Autor:
Michael Darcy, Kyle Crocker, Yuchen Wang, Jenny V. Le, Golbarg Mohammadiroozbahani, Mahmoud A. S. Abdelhamid, Timothy D. Craggs, Carlos E. Castro, Ralf Bundschuh, Michael G. Poirier
Publikováno v:
ACS Nano. 16:5682-5695
The ability to apply and measure high forces (gt;10 pN) on the nanometer scale is critical to the development of nanomedicine, molecular robotics, and the understanding of biological processes such as chromatin condensation, membrane deformation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72515b4f03fad5cfb34386cfda1e30b6
https://doi.org/10.1021/acsnano.1c10698
https://doi.org/10.1021/acsnano.1c10698
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1930028c08e03a41b64d9d460709abec
https://doi.org/10.1007/978-1-0716-3028-0_2
https://doi.org/10.1007/978-1-0716-3028-0_2
Autor:
Jenny V. Le, Kyle Crocker, Michael G. Poirier, Ralf Bundschuh, Cassie Croy, Dengke Zhao, Yuchen Wang, Michael A. Darcy, Nick Andrioff, Patrick D. Halley, Carlos E. Castro
Publikováno v:
Nucleic Acids Research
Single molecule force spectroscopy is a powerful approach to probe the structure, conformational changes, and kinetic properties of biological and synthetic macromolecules. However, common approaches to apply forces to biomolecules require expensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4f3d81c49350aa6db2f848672494ca
https://pubmed.ncbi.nlm.nih.gov/34358322
https://pubmed.ncbi.nlm.nih.gov/34358322
Publikováno v:
Nanoscale. 11:1647-1660
Significant advances have been made towards the design, fabrication, and actuation of dynamic DNA nanorobots including the development of DNA origami mechanisms. These DNA origami mechanisms integrate relatively stiff links made of bundles of double-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccabfb49afef10b54c81209b1aab1187
https://doi.org/10.1039/c8nr06377j
https://doi.org/10.1039/c8nr06377j
Autor:
Jenny V. Le, Kyle Crocker, Dengke Zhao, Ralf Bundschuh, Michael A. Darcy, Carlos E. Castro, Michael G. Poirier
Publikováno v:
Biophys J
In eukaryotic cells, DNA is packaged into chromatin where nucleosomes are the basic packaging unit. Important cellular processes including gene expression, DNA replication, and DNA repair require nucleosomal DNA to be unwrapped so that functional pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db280b7ca40f9d6dfca2d33ce2c68302
https://pubmed.ncbi.nlm.nih.gov/31732143
https://pubmed.ncbi.nlm.nih.gov/31732143
Autor:
Michael G. Poirier, Yi Luo, Jenny V. Le, Carlos E. Castro, Michelle F. Goodwin, Christopher R. Lucas, Michael A. Darcy
Publikováno v:
ACS nano. 10(7)
The organization of eukaryotic DNA into nucleosomes and chromatin undergoes dynamic structure changes to regulate genome processing, including transcription and DNA repair. Critical chromatin rearrangements occur over a wide range of distances includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2655ee8b5e82a74e918fa3dc71ede8
https://pubmed.ncbi.nlm.nih.gov/27362329
https://pubmed.ncbi.nlm.nih.gov/27362329
Publikováno v:
Biophysical Journal. 110(3):501a-502a
While biophysical tools such as single molecule fluorescence and force spectroscopy have been used to study the structural dynamics of individual nucleosomes or large chromatin assemblies, it is challenging to probe conformational dynamics of gene re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069d221306f19ef98ce49ec32234c57f