Výsledky vyhledávání - "Jenny Thirlway"

An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells

Autor: Daniel J. Williamson, Sabine Milhas, Jing Zhang, Majid Al Nakeeb, Jenny Thirlway, Adam Lodge, Arvind K. Jain, Ami Miller, Terry Rabbitts, Justyna Helena Mysliwy

Publikováno v: Leukemia Research

Highlights • The CD7 surface protein is highly expressed on T cell acute leukaemias. • CD7 bound by antibody is rapidly processed and internalised into cells. • The novel antibody-drug conjugate kills CD7 expressing leukaemias. • The ADC link

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640911a36f805d6cc6e5cbc1b30b590b
https://pubmed.ncbi.nlm.nih.gov/34062328

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Abstract 1751: Developing a next generation antibody drug conjugate for treatment of gastrointestinal cancers

Autor: Justyna H. Mysliwy, Adam Lodge, Daniel Williamson, Jenny Thirlway, Jutta Deckert, Robert J. Lutz

Publikováno v: Cancer Research. 82:1751-1751

Background: Gastrointestinal cancers (GI) are among the most common cancers worldwide. Current treatment options rely on a chemotherapy backbone combined with targeted antibody therapies, but the prognosis generally remains poor. Iksuda has developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09305d264c04b97b750e50cefac25526
https://doi.org/10.1158/1538-7445.am2022-1751

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Abstract 1753: IKS014, a HER2-targeting antibody drug conjugate incorporating novel bioconjugation and tumor-selective linker technology with improved in vivo efficacy and tolerability

Autor: Jutta Deckert, Jenny Thirlway, Yun-Hee Park, Ho Young Song, Chul-Woong Chung, Xuesong Wang, Zhenshan Zhang, Robert J. Lutz

Publikováno v: Cancer Research. 82:1753-1753

HER2 has long been a target of high interest for antibody and antibody drug conjugate (ADC) therapeutics due to its well-documented overexpression in breast, gastric and lung cancer. While trastuzumab and ado-trastuzumab emtansine (T-DM1) have become

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8b5cdeefc14fe547bcbae93aa0181a8
https://doi.org/10.1158/1538-7445.am2022-1753

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Abstract 1755: IKS03, a CD19-targeted antibody drug conjugate with enhanced efficacy and tolerability for treatment of B-cell lymphomas

Autor: Jenny Thirlway, Adam Lodge, Daniel J. Williamson, Justyna Mysliwy, Jutta Deckert, Xavier Chauchet, Laura Cons, Yun-Hee Park, Hyun-Min Ryu, Na Ra Han, Ho Young Song, Chul-Woong Chung, Robert J. Lutz

Publikováno v: Cancer Research. 82:1755-1755

Background: Lymphoma is the most common hematological malignancy with non-Hodgkin B-cell lymphomas (NHL), including those with high unmet clinical need such as relapsed/refractory Diffuse Large B Cell Lymphoma (DLBCL), and Mantle-Cell Lymphoma (MCL),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c835dc8410529b79e571e68a469c751b
https://doi.org/10.1158/1538-7445.am2022-1755

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IKS01, a next generation antibody drug conjugate (ADC) designed to be efficacious in tumors with low and moderate levels of folate receptor expression

Autor: Paul J. M. Jackson, Jenny Thirlway, A. Pelava, M Al Nakeeb, Adam Lodge, Robert J. Lutz, Justyna Helena Mysliwy, D. Carta, David E. Thurston, Daniel J. Williamson

Publikováno v: Annals of Oncology. 30:v16-v17

Background Frequent over-expression of FRA in ovarian and non-small-cell lung cancer (NSCLC), and relative lack of expression in normal tissue, make it an attractive therapeutic target. Ovarian cancer is the ninth most common cancer in women and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1b3e9afd2416057e6fdaedc2c2c3b6c
https://doi.org/10.1093/annonc/mdz238.056

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Abstract C023: IKS01, a next generation antibody drug conjugate, shows target-dependent efficacy in a platinum-resistant tumor model with low levels of folate receptor α expression

Autor: David E. Thurston, Paul J. M. Jackson, Majid Al Nakeeb, Andria Pelava, Justyna Helena Mysliwy, Daniel J. Williamson, Adam Lodge, Robert J. Lutz, Davide Carta, Jenny Thirlway

Publikováno v: Molecular Cancer Therapeutics. 18:C023-C023

Background: Antibody drug conjugate (ADC) technologies provide selective tumor killing with increased efficacy and less off-target toxicity than standard chemotherapy. Clinical validation of this approach for solid tumors has been limited, with trast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0b0a51286982ecbe20b8c5774dc1398
https://doi.org/10.1158/1535-7163.targ-19-c023

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Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

Autor: Richard A Lewis, Jason Micklefield, Laura Nunns, Colin P. Smith, Majid Al Nakeeb, Anna-Winona Struck, Matthew Q. Styles, Jenny Thirlway

Publikováno v: Angewandte Chemie. 124:7293-7296

Calcium-dependent antibiotics (CDA) are cyclic lipopeptides assembled by nonribosomal peptide synthetase (NRPS) enzymes. Active site modification of the 3-methyl glutamate activating adenylation (A) domain of the CDA NRPS enables the incorporation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb518ba8d373a9c6742498d664eb89d2
https://doi.org/10.1002/ange.201202043

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Engineered Biosynthesis of Nonribosomal Lipopeptides with Modified Fatty Acid Side Chains

Autor: Barrie Wilkinson, Jenny Thirlway, Mathew Borg, Bagher Amirheidari, Colin P. Smith, Jason Micklefield, Amanda Powell, Joanne M. Neary

Publikováno v: Journal of the American Chemical Society. 129:15182-15191

The biological properties of the calcium-dependent antibiotics (CDAs), daptomycin and related nonribosomal lipopeptides, depend to a large extent on the nature of the N-terminal fatty acid moiety. It is suggested that the chain length of the unusuall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04b4c0cb28ff050f8b1770f0de3fe18
https://doi.org/10.1021/ja074331o

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