Výsledky vyhledávání - "Jenny Shapiro"

Akademický článek

Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System

Autor: Jenny Shapiro, Ortal Iancu, Ashley M. Jacobi, Matthew S. McNeill, Rolf Turk, Garrett R. Rettig, Ido Amit, Adi Tovin-Recht, Zohar Yakhini, Mark A. Behlke, Ayal Hendel

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 1097-1107 (2020)

Genome editing of human cluster of differentiation 34+ (CD34+) hematopoietic stem and progenitor cells (HSPCs) holds great therapeutic potential. This study aimed to optimize on-target, ex vivo genome editing using the CRISPR-Cas9 system in CD34+ HSP

Externí odkaz: https://doaj.org/article/74189cca19364566b5cb4597df8b7115

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Increasing CRISPR Efficiency and Measuring Its Specificity in HSPCs Using a Clinically Relevant System

Autor: Mark A. Behlke, Adi Tovin-Recht, Jenny Shapiro, Ayal Hendel, Ashley M. Jacobi, Matthew S. McNeill, Zohar Yakhini, Garrett R. Rettig, Ido Amit, Rolf Turk, Ortal Iancu

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 1097-1107 (2020)
Molecular Therapy-Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baca97288c11dd29a6cc0f972da0d999
http://www.sciencedirect.com/science/article/pii/S2329050120300875

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Chemical Modification of Guide RNAs for Improved CRISPR Activity in CD34+ Human Hematopoietic Stem and Progenitor Cells

Autor: Daniel Allen, Ortal Iancu, Ayal Hendel, Adi Tovin, Jenny Shapiro

Publikováno v: Methods in Molecular Biology ISBN: 9781071606865

Human CD34+ hematopoietic stem and progenitor cells (HSPCs) have the unique ability to repopulate the entire hematopoietic system and thus are at the center of diverse, therapeutically relevant studies. The recent development of the CRISPR/Cas9 tool

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72a5fb0c310530607dd8455f7cdf9dd6
https://doi.org/10.1007/978-1-0716-0687-2_3

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Chemical Modification of Guide RNAs for Improved CRISPR Activity in CD34+ Human Hematopoietic Stem and Progenitor Cells

Autor: Jenny, Shapiro, Adi, Tovin, Ortal, Iancu, Daniel, Allen, Ayal, Hendel

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2162

Human CD34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2842c106183a2fd7c5333ec5f5761673
https://pubmed.ncbi.nlm.nih.gov/32926376

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Active Aβ vaccination fails to enhance amyloid clearance in a mouse model of Alzheimer's disease with Aβ42-driven pathology

Autor: Anna Nemirovsky, Alex Kompaniets, Alon Monsonego, Jenny Shapiro, Rona Baron

Publikováno v: Journal of Neuroimmunology. 247:95-99

Aβ vaccination has been shown to induce remarkable clearance of brain amyloid plaques in mouse models of Alzheimer's disease (AD). However, the extent to which antibody-mediated Aβ clearance is affected by predominant formation of Aβ42 over Aβ40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3a4994e6468d7f71b2e4044986b09d
https://doi.org/10.1016/j.jneuroim.2012.03.017

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TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

Autor: Jenny Shapiro, Nitzan Levy, Shai Abutbul, Irit Szaingurten-Solodkin, Steffen Jung, Rona Baron, Yaron Carmy, Alon Monsonego

Publikováno v: Glia. 60:1160-1171

Microglia are myeloid-derived cells that colonize the central nervous system (CNS) at early stages of development and constitute up to 20% of the glial populations throughout life. While extensive progress has been recently made in identifying the ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b30a33fa032c42941c22849579176a
https://doi.org/10.1002/glia.22343

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Stromal cell-induced immune regulation in a transplantable lymphoid-like cell constructs

Autor: Alon Monsonego, Jenny Shapiro, Smadar Cohen, Yael Kaminer-Israeli

Publikováno v: Biomaterials. 31(35)

Engineering of cell-based constructs for treating a variety of immune-related diseases by local transplantation of the cells in a pre-designed matrix is an emerging therapeutic approach, which can potentially reduce the side effects associated with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f42cbc14b80e8e0fe0edf457ce0555f
https://pubmed.ncbi.nlm.nih.gov/20869768

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Akademický článek

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