Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jenny Schröder"'
Publikováno v:
BIOspektrum. 23:422-423
In tissues, cells are spatially organized in three dimensions and interact with neighbouring cells and the extracellular matrix (ECM). This can be mimicked in vitro with a new 3D cell culture system that is using the most abundant ECM molecule to emb
LIMP-2 Is a Receptor for Lysosomal Mannose-6-Phosphate-Independent Targeting of β-Glucocerebrosidase
Autor:
David Reczek, Tim Edmunds, Scott M. Van Patten, Judith Blanz, Paul Saftig, William Brondyk, Heather Hughes, Jenny Schröder, Xiaoying Jin, Michael Schwake
Publikováno v:
Cell. 131:770-783
beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a spe
Autor:
Ulrike Zimmermann, Eeva-Liisa Eskelinen, Paul Saftig, Michael Schwake, Renate Lüllmann-Rauch, Lukas Rüttiger, Cathrin Claussen, Jenny Schröder, Marlies Knipper
Publikováno v:
The Journal of Physiology. 576:73-86
Our previous studies revealed a critical role of the lysosomal membrane protein LIMP2 in the regulation of membrane transport processes in the endocytic pathway. Here we show that LIMP2-deficient mice display a progressive high-frequency hearing loss
Autor:
Nina Himmerkus, Paul Saftig, Irina Pleines, Friedrich Koch-Nolte, Markus Bleich, Renate Lüllmann-Rauch, Zane Orinska, Bernhard Nieswandt, Bernd Schröder, Jenny Schröder
Publikováno v:
Molecular and cellular biology. 29(4)
CD63 is a member of the tetraspanin superfamily that constitutes a main component of the lysosomal membrane. In mice, two CD63 gene loci are present, with only one of these two being functional. We generated and analyzed mice deficient for active CD6