Výsledky vyhledávání - "Jenny S. Nuxoll"

Estrogen receptor alpha signaling promotes Sle1-induced loss of tolerance and immune cell activation and is responsible for sex bias in B6.Sle1 congenic mice

Autor: Jenny S. Nuxoll, Shayla D. Yoachim, Kimberly K. Bynoté, Karen A. Gould

Publikováno v: Clinical Immunology. 158:153-166

Sex bias in lupus incidence is thought to be due, in part, to the ability of estrogens to promote loss of tolerance. Previously, we showed that estrogens promote lupus via estrogen receptor α (ERα). C57BL/6 (B6) mice carrying the Sle1 lupus suscept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6cdc43fe3b184b2393149d9a05bd22
https://doi.org/10.1016/j.clim.2015.03.026

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A Dexamethasone Prodrug Reduces the Renal Macrophage Response and Provides Enhanced Resolution of Established Murine Lupus Nephritis

Autor: Dana E. Tabor, Kimberly K. Bynoté, Jenny S. Nuxoll, Subodh M. Lele, Fang Yuan, Dong Wang, Richard K. Nelson, Yijia Zhang, Hongjiang Yuan, Karen A. Gould

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 11, p e81483 (2013)

We evaluated the ability of a macromolecular prodrug of dexamethasone (P-Dex) to treat lupus nephritis in (NZB × NZW)F1 mice. We also explored the mechanism underlying the anti-inflammatory effects of this prodrug. P-Dex eliminated albuminuria in mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315be969aa956b90c14903fe70fb40b3
https://doi.org/10.1371/journal.pone.0081483

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