Zobrazeno 1 - 10
of 407
pro vyhledávání: '"Jenny P.-Y. Ting"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113852- (2024)
Summary: The NLRP3 inflammasome is essential for caspase-1 activation and the release of interleukin (IL)-1β, IL-18, and gasdermin-D in myeloid cells. However, research on species-specific NLRP3’s physiological impact is limited. We engineer mice
Externí odkaz:
https://doaj.org/article/73a3933d8dcb417398db4efc4f97a270
Autor:
Liang Cheng, Guangming Li, Caroline Marnata Pellegry, Fumihiko Yasui, Feng Li, Sandra M. Zurawski, Gerard Zurawski, Yves Levy, Jenny P.-Y. Ting, Lishan Su
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mice reconstituted with a human immune system (humanized mice) provide a robust model to study human immunology, vaccinology, and human infectious diseases. However, the development and function of B cells in humanized mice is impaired. B cells from
Externí odkaz:
https://doaj.org/article/0d4747154cc34c16a3c7cfd59ed382e8
Autor:
Juin-Hua Huang, Chu-Yu Liu, Sheng-Yang Wu, Wen-Yu Chen, Tzu-Hsuan Chang, Hung-Wei Kan, Sung-Tsang Hsieh, Jenny P.-Y. Ting, Betty A. Wu-Hsieh
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
LC3-associated phagocytosis (LAP) is an emerging non-canonical autophagy process that bridges signaling from pattern-recognition receptors (PRRs) to autophagic machinery. LAP formation results in incorporation of lipidated LC3 into phagosomal membran
Externí odkaz:
https://doaj.org/article/8f96456115a94d2b8a640dcf35b33030
Autor:
A. Alicia Koblansky, Agnieszka D. Truax, Rongrong Liu, Stephanie A. Montgomery, Shengli Ding, Justin E. Wilson, W. June Brickey, Marcus Mühlbauer, Rita-Marie T. McFadden, Peizhen Hu, Zengshan Li, Christian Jobin, Pauline Kay Lund, Jenny P.-Y. Ting
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2562-2575 (2016)
NOD-like receptor (NLR) proteins are intracellular innate immune sensors/receptors that regulate immunity. This work shows that NLRX1 serves as a tumor suppressor in colitis-associated cancer (CAC) and sporadic colon cancer by keeping key tumor promo
Externí odkaz:
https://doaj.org/article/34ab2efd86b9407a944984329d41cb46
Autor:
Annette M. Uittenbogaard, R. Lakshman Chelvarajan, Tanya eMyers-Morales, Amanda A. Gorman, W. June Brickey, Zhan eYe, Alan M. Kaplan, Donald A. Cohen, Jenny P.-Y. Ting, Susan C. Straley
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
YopM is one of the six effector Yops of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in i
Externí odkaz:
https://doaj.org/article/137463cd821e4008999c8df2193823b3
Publikováno v:
Cell. 186:2288-2312
Publikováno v:
Cancer Discovery. 13:19-22
Summary:In this issue, Hattori and colleagues capitalized on targeted small-molecule covalent inhibitors of one KRAS mutant with a G12C substitution and of other oncoproteins to create drug–peptide conjugates that serve as cancer neoantigens that p
Autor:
Kaiting Yang, Wenbo Han, Xiaomin Jiang, Andras Piffko, Jason Bugno, Chuanhui Han, Sirui Li, Hua Liang, Ziwan Xu, Wenxin Zheng, Liangliang Wang, Jiaai Wang, Xiaona Huang, Jenny P. Y. Ting, Yang-Xin Fu, Wenbin Lin, Ralph R. Weichselbaum
Publikováno v:
Nature Nanotechnology. 17:1322-1331
The clinical utility of stimulator of interferon genes (STING) agonists has been limited due to poor tumour-targeting and unwanted toxicity following systemic delivery. Here we describe a robust tumour-targeted STING agonist, ZnCDA, formed by the enc
Autor:
Sirui Li, Bhalchandra Mirlekar, Brandon M. Johnson, W. June Brickey, John A. Wrobel, Na Yang, Dingka Song, Sarah Entwistle, Xianming Tan, Meng Deng, Ya Cui, Wei Li, Benjamin G. Vincent, Michael Gale, Yuliya Pylayeva-Gupta, Jenny P.-Y. Ting
Publikováno v:
Nature
An immunosuppressive tumour microenvironment is a major obstacle in the control of pancreatic and other solid cancers(1–3). Agonists of the stimulator of interferon genes (STING) protein trigger inflammatory innate immune responses to potentially o
Autor:
Matthew D. Gallovic, Robert D. Junkins, Adam M. Sandor, Erik S. Pena, Christopher J. Sample, Ariel K. Mason, Leslee C. Arwood, Rebecca A. Sahm, Eric M. Bachelder, Kristy M. Ainslie, Gregory D. Sempowski, Jenny P.-Y. Ting
Publikováno v:
J Control Release
The COVID-19 pandemic highlights the need for effective vaccines against respiratory viruses. An ideal vaccine should induce robust and long-lasting responses with high manufacturing scalability. We used an adjuvant comprised of a Stimulator of Inter