Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jenny P Johns"'
Autor:
Glen M Boyle, Marjorie M A D'Souza, Carly J Pierce, Ryan A Adams, Aaron S Cantor, Jenny P Johns, Lidia Maslovskaya, Victoria A Gordon, Paul W Reddell, Peter G Parsons
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108887 (2014)
Intra-lesional chemotherapy for treatment of cutaneous malignancies has been used for many decades, allowing higher local drug concentrations and less toxicity than systemic agents. Here we describe a novel diterpene ester, EBC-46, and provide precli
Externí odkaz:
https://doaj.org/article/bb2e02be590046c3957ad6e86c353017
Autor:
Craig M. Williams, Natasa Broit, Alberto Pagani, Giovanni Appendino, Lidia A. Maslovskaya, Jenny P. Johns, Jacinta L. Simmons, Glen M. Boyle, Stefan Elmlinger, Blake Ferguson, Peter G. Parsons, Achim Porzelle, Paul Reddell, Paul V. Bernhardt, Pei Yi Yap, Jason K. Cullen, Andrei I. Savchenko, Victoria A. Gordon, Paul Malek Mirzayans
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
The long-standing perception of Protein Kinase C (PKC) as a family of oncoproteins has increasingly been challenged by evidence that some PKC isoforms may act as tumor suppressors. To explore the hypothesis that activation, rather than inhibition, of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323962573ce99a67035d5b7c004178c1
https://doaj.org/article/48af2e8d91fb499798d2ad925238a5a8
https://doaj.org/article/48af2e8d91fb499798d2ad925238a5a8
Autor:
Rachel Anne Howard-Jones, Paul Reddell, Rachael L. Moses, Jenny P. Johns, Glen M. Boyle, Ryan Moseley, Rachel J. Errington, Victoria A. Gordon, Robert Steadman
Publikováno v:
Biochemical pharmacology. 178
Epoxy-tiglianes are a novel class of diterpene esters. The prototype epoxy-tigliane, EBC-46 (tigilanol tiglate), possesses potent anti-cancer properties and is currently in clinical development as a local treatment for human and veterinary cutaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1149cceea05cd1111d569f934dfb4b7a
https://pubmed.ncbi.nlm.nih.gov/32446889
https://pubmed.ncbi.nlm.nih.gov/32446889
Autor:
Lin Dong, Peter G. Parsons, Paul V. Bernhardt, Michael Gallen, Heiko Schill, Jenny P. Johns, Rebecca L. Grange, Victoria Anne Gordon, Craig M. Williams, Paul Reddell
Publikováno v:
Chemistry - A European Journal. 16:8894-8903
A detailed examination of [4+2] cycloaddition reactions between 1,8-disubstituted cyclooctatetraenes and diazo compounds revealed that 4-phenyl-1,2,4-triazole-3,5-dione (PTAD) reacts to form either 2,3- or 3,4-disubstituted adducts. The product distr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd13a44533cff56a08815416f5b891e
https://doi.org/10.1002/chem.200903454
https://doi.org/10.1002/chem.200903454
Autor:
Andreas Suhrbier, Melanie Morris, James Harrison Aylward, Glen M. Boyle, Thuy T. Le, Brad Jones, Sarah-Jane Cozzi, Aleksandra Lenarczyk, Joy Gardner, Steven M. Ogbourne, Kirsty P. Sutherland, Peter G. Parsons, Tania M. Scott, Jenny P. Johns, Devi McAlpine
Publikováno v:
Cancer Research. 64:2833-2839
Options for skin cancer treatment currently include surgery, radiotherapy, topical chemotherapy, cryosurgery, curettage, and electrodessication. Although effective, surgery is costly and unsuitable for certain patients. Radiotherapy can leave a poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adde6b61280a86d0c8dcb8db1072dc91
https://doi.org/10.1158/0008-5472.can-03-2837
https://doi.org/10.1158/0008-5472.can-03-2837
Autor:
Aaron S. Cantor, Peter G. Parsons, Lidia A. Maslovskaya, Jenny P. Johns, Marjorie M. A. D'Souza, Carly J. Pierce, Paul Reddell, Ryan A. Adams, Glen M. Boyle, Victoria A. Gordon
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e108887 (2014)
PLoS ONE
PLoS ONE
Intra-lesional chemotherapy for treatment of cutaneous malignancies has been used for many decades, allowing higher local drug concentrations and less toxicity than systemic agents. Here we describe a novel diterpene ester, EBC-46, and provide precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696ba0bbcbcfb16106692726fb9354ea
http://europepmc.org/articles/PMC4182759?pdf=render
http://europepmc.org/articles/PMC4182759?pdf=render
Autor:
Jenny P. Johns, Michael Gallen, Paul Reddell, Peter G. Parsons, Craig M. Williams, Rebecca L. Grange, Victoria Anne Gordon, Paul V. Bernhardt, Heiko Schill, Lin Dong
Publikováno v:
ChemInform. 41
A detailed examination of the title reaction is presented employing triazoledione (II) or azodicarboxylate (IX) as diazo dienophiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ec8b35ff75162760ec9093205cc5704
https://doi.org/10.1002/chin.201050160
https://doi.org/10.1002/chin.201050160
Autor:
Craig M. Williams, Jenny P. Johns, Achim Porzelle, Paul Reddell, Heiko Schill, Lin Dong, Peter G. Parsons, Rebecca L. Grange, Victoria A. Gordon
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 15(42)
EBC-23, 24, 25, 72, 73, 75 and 76 were isolated from the fruit of Cinnamomum laubatii (family Lauraceae) in the Australian tropical rainforests. EBC-23 (1) was synthesized stereoselectively, in nine linear steps in 8 % overall yield, to confirm the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbfd896c423a90f1b41fb70871da2fa
https://pubmed.ncbi.nlm.nih.gov/19750529
https://pubmed.ncbi.nlm.nih.gov/19750529
Autor:
Jenny P. Johns, Antony Bacic, David McManus, Peter G. Parsons, Rong-Wei Teng, Steven M. Ogbourne, James Harrison Aylward
Publikováno v:
Fitoterapia. 80(4)
Acylation of 3-O-angeloylingenol (1) with vinyl acetate, vinyl decanoate and vinyl cinnamate, catalyzed by Candida antarctica Lipase B, was investigated. In each case, compound 1 was quantitatively and regioselectively acylated to afford a single pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90baa1692a4d0b4ebc204aeede0b2b2
https://pubmed.ncbi.nlm.nih.gov/19535013
https://pubmed.ncbi.nlm.nih.gov/19535013
Structure and Absolute Stereochemistry of the Anticancer Agent EBC-23 from the Australian Rainforest
Autor:
Achim Porzelle, Lin Dong, Jenny P. Johns, Craig M. Williams, Paul Reddell, Peter G. Parsons, Rebecca L. Grange, Victoria A. Gordon, Heiko Schill
Publikováno v:
Journal of the American Chemical Society. 130:15262-15263
EBC-23 (2), a prostate anticancer agent, was isolated from the fruit of Cinnamomum laubatii (family Lauraceae) in the Australian tropical rainforest. Extensive NOE experiments enabled the relative stereochemistry of the proposed EBC-23 (2) structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74128e4b6c54761348589de6eab70bd6
https://doi.org/10.1021/ja807133p
https://doi.org/10.1021/ja807133p