Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jenny McKinnell"'
Autor:
Scott Jacobson, Dennis X. Hu, Cesar Meleza, Mikhail Zibinsky, Ashkaan Younai, Erin Riegler, Omar Robles, Jenny McKinnell, Emily Karbarz, Paul D. Kassner, Lisa A. Marshall, Maureen Kay Reilly, David Chian, Gene Cutler, David J. Wustrow, Dirk G. Brockstedt, Hunter P. Shunatona, Raymond Diokno, Angela Wadsworth, John M. Ketcham, Oezcan Talay, Jeffrey J. Jackson
Publikováno v:
Journal of Medicinal Chemistry. 63:8584-8607
The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (Treg) as well as other circulating and tissue-resident T cells. Treg can be recruited to the tumor microenvironment (TME) through the C-C chemokines CCL17 and CCL22. Treg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff8f25af0448a07583421b7d8d0bfa7
https://doi.org/10.1021/acs.jmedchem.0c00988
https://doi.org/10.1021/acs.jmedchem.0c00988
Autor:
Deepa Pookot, Scott Jacobson, John M. Ketcham, David Chian, Emily Karbarz, Dennis X. Hu, James Ross Walker, Gene Cutler, Ashkaan Younai, Mikhail Zibinsky, Raymond Diokno, David J. Wustrow, Betty Abraham, Angela Wadsworth, Maureen Kay Reilly, Cesar Meleza, Jenny McKinnell, Jeffrey J. Jackson, Abood Okal, Paul D. Kassner, Lisa A. Marshall, Oezcan Talay, Berenger Biannic, Bui Minna H T, Hilary Plake Beck, Hunter P. Shunatona, Omar Robles
Publikováno v:
Journal of Medicinal Chemistry. 62:6190-6213
Recruitment of suppressive CD4+ FOXP3+ regulatory T cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human Treg express CCR4 and can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c664d1b35dae60b88d59898f44ef53
https://doi.org/10.1021/acs.jmedchem.9b00506
https://doi.org/10.1021/acs.jmedchem.9b00506
Autor:
Daniel W. Robbins, Nivetha Brathaban, Dane E. Karr, Austin Tenn-McClellan, Arthur T. Sands, Jun Ma, May Tan, Gwenn M. Hansen, Timothy Ingallinera, Jenny McKinnell, Cristiana Guiducci, Ryan Rountree, Aileen Kelly, Zef Konst, Luz Perez, Mark Noviski
Publikováno v:
Blood. 138:2251-2251
Bruton's tyrosine kinase (BTK) plays a key role in cell survival in B cell malignancies, and covalent inhibitors of BTK, such as ibrutinib and acalabrutinib, have proven efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f9e8e6d28add21cfafc5080ef439b17
https://doi.org/10.1182/blood-2021-147473
https://doi.org/10.1182/blood-2021-147473
Autor:
Jeffrey J, Jackson, John M, Ketcham, Ashkaan, Younai, Betty, Abraham, Berenger, Biannic, Hilary P, Beck, Minna H T, Bui, David, Chian, Gene, Cutler, Raymond, Diokno, Dennis X, Hu, Scott, Jacobson, Emily, Karbarz, Paul D, Kassner, Lisa, Marshall, Jenny, McKinnell, Cesar, Meleza, Abood, Okal, Deepa, Pookot, Maureen K, Reilly, Omar, Robles, Hunter P, Shunatona, Oezcan, Talay, James R, Walker, Angela, Wadsworth, David J, Wustrow, Mikhail, Zibinsky
Publikováno v:
Journal of medicinal chemistry. 62(13)
Recruitment of suppressive CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85180faa74d36bfcafdd7b76884ccac3
https://pubmed.ncbi.nlm.nih.gov/31259550
https://pubmed.ncbi.nlm.nih.gov/31259550
Autor:
Ryan Rountree, Dane E Karr, Luz Perez, Austin Tenn-McClellan, G. Hansen, Jenny McKinnell, Zef Konst, Mark Noviski, M. Tan, Aileen Kelly, Timothy Ingallinera, Daniel W. Robbins, Cristiana Guiducci
Publikováno v:
Annals of the Rheumatic Diseases. 80:204.1-205
Background:Aberrant activation of B cells and autoantibody mediated tissue damage are hallmarks of autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Therefore, novel treatments that prevent autoantibody gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8105690a77d5a499911df154f261b6c2
https://doi.org/10.1136/annrheumdis-2021-eular.1675
https://doi.org/10.1136/annrheumdis-2021-eular.1675
Autor:
Jennifer Tung, Luz Perez, Timothy Ingallinera, Jordan Ye, Aileen Kelly, May Tan, Ge Peng, Sasha Borodovsky, Zef Konst, Austin Tenn-McClellan, Ryan Rountree, Steve Basham, Jeffrey H. Wu, Jenny McKinnell, Dahlia Weiss, Arthur T. Sands, Cristiana Guiducci, Mark Noviski, Mcintosh Joel, Dane E Karr, Janine Powers, Daniel W. Robbins, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic
Publikováno v:
Blood. 136:34-34
Bruton's tyrosine kinase (BTK) plays a key role in cell survival in B cell malignancies, such as chronic lymphocytic leukemia (CLL). Covalent inhibitors of BTK, such as ibrutinib and acalabrutinib, while effective, have been associated with the occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::492f0dbdb2ad9ad3c62ea1d2da14dc82
https://doi.org/10.1182/blood-2020-141461
https://doi.org/10.1182/blood-2020-141461
Autor:
Christoph W. Zapf, May Tan, Mario G. Cardozo, Ge Peng, Jennifer Tung, Mcintosh Joel, Arthur T. Sands, Ryan Rountree, Zef Konst, Jordan Ye, Aileen Kelly, Jeffrey H. Wu, Luz Perez, Neil Bence, Timothy Ingallinera, Dahlia Weiss, Mark Noviski, Steve Basham, Austin Tenn-McClellan, Jenny McKinnell, Daisuke Kato, Anna Kolobova, Jeffrey T. Mihalic, Daniel W. Robbins, Dane E Karr
Publikováno v:
Blood. 134:3805-3805
Bruton's tyrosine kinase (BTK) is a key component of B cell receptor signaling and is involved in B cell development and function. BTK plays a crucial role in cell survival in B cell malignancies such as Chronic Lymphocytic Leukemia (CLL), and covale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b95ae450ec2bc4afe8f06a32c74d624
https://doi.org/10.1182/blood-2019-129262
https://doi.org/10.1182/blood-2019-129262
Autor:
Kyle Young, Jacob Bradley Schwarz, Delia Bradford, Michael Sun, Gene Cutler, Jenny McKinnell, David Chian, Cesar Meleza, Grant M. Shibuya, Silpa Suthram, Betty Abraham, Andrew Napper, Martin Brovarney, David J. Wustrow, Akinori Okano, Paul Leger, Leanne Peiser, Deepika Kaveri, Nick Shah, Xinping Han, Sherra Johnson, Deepa Pookot, Oezcan Talay, Sachie Marubayashi, Scott Jacobson, Berenger Biannic, Dennis X. Hu, Lavanya Adusumilli, Yamini M. Ohol, Jack Maung, Paul D. Kassner, Lisa A. Marshall, Angela Wadsworth, John M. Ketcham, Andrea Kim, Payal Rana
Publikováno v:
Cancer Research. 78:2915-2915
USP7 is a deubiquitinase (DUB) that has attracted much attention recently due to its multiple roles in promoting cancer progression. By removal of ubiquitin from protein substrates, USP7 stabilizes oncogenes such as MDM2 and Myc, destabilizes and ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf5fa08d2765e5cfa27d6d80063309b2
https://doi.org/10.1158/1538-7445.am2018-2915
https://doi.org/10.1158/1538-7445.am2018-2915
Autor:
Lisa Seitz, Omar Robles, Abood Okal, Erin Riegler, Emily Karbaz, Scott Jacobson, Jenny McKinnell, Angela Wadsworth, Oezcan Talay, Paul D. Kassner, Lisa A. Marshall, David Chian, David J. Wustrow, Maureen Kay Reilly, Mikhail Zibisky, Cesar Meleza, Jordan S. Fridman
Publikováno v:
Cancer Research. 77:4600-4600
Naturally suppressive CD4+ Foxp3+ Treg are essential for immune tolerance. Although Treg-mediated suppression of effector cells is important to control inflammation and prevent autoimmune diseases, the presence of Treg in the tumor microenvironment (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b87bf475ea463f95dd6cca5fc91857
https://doi.org/10.1158/1538-7445.am2017-4600
https://doi.org/10.1158/1538-7445.am2017-4600
Publikováno v:
Proceedings of the 2012 4th IEEE Software Engineering Colloquium (SE).
Generally in South Africa the commentary about our competitiveness in the retail, financial services, banking and other industries reveals that we are not growing our businesses into the African continent as fast as other countries despite our presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb10c22b508b9bb8de17ae366472a19
https://doi.org/10.1109/se.2012.6242351
https://doi.org/10.1109/se.2012.6242351