Data from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Autor: David J. Adams, Tim Hubbard, Lara S. Collier, Anton Berns, Maarten van Lohuizen, P. Andy Futreal, Michael R. Stratton, David A. Largaespada, Louise van der Weyden, Catherine H. Wilson, Markus Brosch, Alistair G. Rust, Adam Butler, Graham R. Bignell, Jos Jonkers, Lodewyk Wessels, Jeroen de Ridder, Anthony G. Uren, Jaap Kool, Jenny Mattison

Comparative genomic hybridization (CGH) can reveal important disease genes but the large regions identified could sometimes contain hundreds of genes. Here we combine high-resolution CGH analysis of 598 human cancer cell lines with insertion sites is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559c580e0196c98d38f7d71fd3dbe244
https://doi.org/10.1158/0008-5472.c.6501584.v1

Supplementary Tables 1-5 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Autor: David J. Adams, Tim Hubbard, Lara S. Collier, Anton Berns, Maarten van Lohuizen, P. Andy Futreal, Michael R. Stratton, David A. Largaespada, Louise van der Weyden, Catherine H. Wilson, Markus Brosch, Alistair G. Rust, Adam Butler, Graham R. Bignell, Jos Jonkers, Lodewyk Wessels, Jeroen de Ridder, Anthony G. Uren, Jaap Kool, Jenny Mattison

Supplementary Tables 1-5 from Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68821b146c652a6305f71cf1619161f8
https://doi.org/10.1158/0008-5472.22386593

Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach

Autor: Jeroen de Ridder, Michael R. Stratton, Jos Jonkers, David A. Largaespada, Lara S. Collier, Alistair G. Rust, Anthony G. Uren, Louise van der Weyden, Jaap Kool, Markus Brosch, Adam Butler, David J. Adams, Anton Berns, Graham R. Bignell, Catherine H. Wilson, Maarten van Lohuizen, P. Andy Futreal, Tim Hubbard, Jenny Mattison, Lodewyk F. A. Wessels

Publikováno v: Cancer Research. 70:883-895

Comparative genomic hybridization (CGH) can reveal important disease genes but the large regions identified could sometimes contain hundreds of genes. Here we combine high-resolution CGH analysis of 598 human cancer cell lines with insertion sites is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::314a6279b5b1a39fef6f52400f36b9dc
https://doi.org/10.1158/0008-5472.can-09-1737

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

Autor: Jenny Mattison, Lodewyk F. A. Wessels, Marcel J. T. Reinders, Jos Jonkers, Anton Berns, Anthony G. Uren, Tony Cox, David J. Adams, Jane Rogers, Jeroen de Ridder, Daoud Sie, Jaap Kool, Tim Hubbard, Konstantin Matentzoglu, Wendy Lagcher, Miranda van Uitert, Ellen Tanger, Maarten van Lohuizen

Publikováno v: Cell, 133(4), 727-41. Cell Press
Cell
Uren, A G, Kool, J, Matentzoglu, K, de Ridder, J, Mattison, J, van Uitert, M, Lagcher, W, Sie, D, Tanger, E, Cox, T, Reinders, M, Hubbard, T J, Rogers, J, Jonkers, J, Wessels, L, Adams, D J, van Lohuizen, M & Berns, A 2008, ' Large-scale mutagenesis in p19(ARF)-and p53-deficient mice identifies cancer genes and their collaborative networks ', Cell, vol. 133, no. 4, pp. 727-41 . https://doi.org/10.1016/j.cell.2008.03.021

p53 and p19(ARF) are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either p53 or p19(ARF) deficiency, we identified 10,806 retroviral insertion sites, implicating over 300 l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5206d28e85f7e18bda91d5a016023d8
https://research.vumc.nl/en/publications/5df98896-eb8f-455d-b7a7-9522a70d4a2c