BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

Autor: Jenny M. Hoffmann, John R. Grünberg, Ann Hammarstedt, Tobias Kroon, Thomas U. Greiner, Stefanie Maurer, Ivet Elias, Vilborg Palsdottir, Fatima Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith

Publikováno v: Molecular Metabolism, Vol 32, Iss , Pp 15-26 (2020)

Objective: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WA

Externí odkaz: https://doaj.org/article/f9ddf0eaf4ad46ecababbbec31f4fdd4

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver.

Autor: Roxana Khatib Shahidi, Jenny M Hoffmann, Shahram Hedjazifar, Laurianne Bonnet, Ritesh K Baboota, Stephanie Heasman, Christopher Church, Ivet Elias, Fatima Bosch, Jeremie Boucher, Ann Hammarstedt, Ulf Smith

Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0247300 (2021)

ObjectiveGremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 dia

Externí odkaz: https://doaj.org/article/56874d5e62914cb6835372b1a006b4c0

Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver

Autor: Jenny M. Hoffmann, Ivet Elias, Roxana Khatib Shahidi, Jeremie Boucher, Ann Hammarstedt, Christopher Church, Shahram Hedjazifar, Fatima Bosch, Laurianne Bonnet, Ritesh K. Baboota, Ulf Smith, Stephanie Heasman

Publikováno v: PLoS ONE, Vol 16, Iss 2, p e0247300 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
PLoS ONE

Objective Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c23c3d349c274ae67ef90e0426f6d1
https://doaj.org/article/56874d5e62914cb6835372b1a006b4c0

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

Autor: Alan Saghatelian, John J. Castellot, Johannes Elvin, Barbara B. Kahn, Lan Wei, Ann Hammarstedt, Claes Ohlsson, Sofia Movérare-Skrtic, Fredrik Bäckhed, Shahram Hedjazifar, Annika Nerstedt, Louise Mannerås Holm, Ismail Syed, Fatima Bosch, Jenny M. Hoffmann, John R. Grünberg, Ulf Smith, Lachmi Jenndahl

Publikováno v: Scientific Reports
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Grünberg, J R, Hoffmann, J M, Hedjazifar, S, Nerstedt, A, Jenndahl, L, Elvin, J, Castellot, J, Wei, L, Movérare-Skrtic, S, Ohlsson, C, Holm, L M, Bäckhed, G F, Syed, I, Bosch, F, Saghatelian, A, Kahn, B B, Hammarstedt, A & Smith, U 2017, ' Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance ', Scientific Reports, vol. 7, 43515 . https://doi.org/10.1038/srep43515

WISP2 is a novel adipokine, most highly expressed in the adipose tissue and primarily in undifferentiated mesenchymal cells. As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as an intracellular protein, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049d8ccd87993b9a6189f6501dc9c85c
http://europepmc.org/articles/PMC5327486

BMP4 and BMP Antagonists Regulate Human White and Beige Adipogenesis

Autor: Cristina M. Rondinone, Ulf Smith, Shahram Hedjazifar, Joseph Grimsby, Ann Hammarstedt, Jenny M. Hoffmann, Birgit Gustafson, Per-Arne Svensson

Publikováno v: Diabetes. 64(5)

The limited expandability of subcutaneous adipose tissue, due to reduced ability to recruit and differentiate new adipocytes, prevents its buffering effect in obesity and is characterized by expanded adipocytes (hypertrophic obesity). Bone morphogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95b4febe1f63ef8b50ad7108e94b5ec
https://pubmed.ncbi.nlm.nih.gov/25605802