Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jenny M Oldham"'
Autor:
Heather K Smith, Kenneth G Matthews, Jenny M Oldham, Ferenc Jeanplong, Shelley J Falconer, James J Bass, Mônica Senna-Salerno, Jeremy W Bracegirdle, Christopher D McMahon
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94356 (2014)
Skeletal muscles of myostatin null (Mstn(-/-)) mice are more susceptible to atrophy during hind limb suspension (HS) than are muscles of wild-type mice. Here we sought to elucidate the mechanism for this susceptibility and to determine if Mstn(-/-) m
Externí odkaz:
https://doaj.org/article/8a5f4e4b6c694a08806bf26ee71f3e17
Autor:
Ferenc Jeanplong, Shelley J Falconer, Jenny M Oldham, Mark Thomas, Tarra S Gray, Alex Hennebry, Kenneth G Matthews, Frederick C Kemp, Ketan Patel, Carole Berry, Gina Nicholas, Christopher D McMahon
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81713 (2013)
Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals. Here we describe the splicing of a cryptic intron that removes the coding seq
Externí odkaz:
https://doaj.org/article/4f9ba57ff9a6476e82269b6e474e45fe
Autor:
Tony Reglinski, Joel L. Vanneste, Magan M. Schipper, Deirdre A. Cornish, Janet Yu, Jenny M. Oldham, Christina Fehlmann, Frank Parry, Duncan Hedderley
Publikováno v:
Plants, Vol 12, Iss 4, p 833 (2023)
The plant defence inducer Actigard® (acibenzolar-S-methyl [ASM]) is applied before flowering and after fruit harvest to control bacterial canker in kiwifruit caused by Pseudomonas syringae pv. actinidiae. Pre-flowering application of ASM is known to
Externí odkaz:
https://doaj.org/article/550cb1be6f7642d18390ccb358bc58a1
Autor:
Jenny M. Oldham, Kenneth G. Matthews, Mark Thomas, Heather K. Smith, Kim Whiteman, Christopher D. McMahon, Ferenc Jeanplong, Shelley J. Falconer, Trevor Watson, Ryan G. Paul
Publikováno v:
Journal of Endocrinology. 248:207-220
Insulin-like growth factor-1 (IGF1) is crucial for regulating post-natal growth and, along with myostatin (MSTN), regulates muscle size. Here, we sought to clarify the roles of these two genes in regulating sexually dimorphic growth of body and muscl
Autor:
Miranda D. Grounds, Jenny M. Oldham, Philip W. Sheard, Jeremy Bracegirdle, Tea Shavlakadze, Carole Berry, Alexander Hennebry, Marta L. Fiorotto, Heather K. Smith, Gina Nicholas, Christopher D. McMahon, Ferenc Jeanplong, Shelley J. Falconer, Trevor Watson, Monica Senna-Salerno, Kenneth G. Matthews
Publikováno v:
Journal of Endocrinology. 234:187-200
Insulin-like growth factors (IGFs) and myostatin have opposing roles in regulating the growth and size of skeletal muscle, with IGF1 stimulating, and myostatin inhibiting, growth. However, it remains unclear whether these proteins have mutually depen
Autor:
Ferenc Jeanplong, Shelley J. Falconer, Claire C. Osepchook, Jenny M. Oldham, Heather K. Smith, J J Bass, Christopher D. McMahon
Publikováno v:
Domestic Animal Endocrinology. 52:17-24
Undernutrition suppresses the growth of skeletal muscles and alters the expression of insulin-like growth factor 1 (IGF1), a key mitogen, and myostatin, a potent inhibitor of myogenesis. These changes can explain, at least in part, the reduced growth
Identification and expression of a novel transcript of the growth and differentiation factor-11 gene
Autor:
Christopher D. McMahon, Jenny M. Oldham, Nauman J. Maqbool, Alex Hennebry, Ferenc Jeanplong, Shelley J. Falconer, Mark Thomas
Publikováno v:
Molecular and Cellular Biochemistry. 390:9-18
The growth and differentiation factor-11 (GDF-11) gene is thought to code for a single protein that plays a crucial role in regulating the development of multiple tissues. In this study, we aimed to investigate if the GDF-11 gene has another transcri
Autor:
Trevor Watson, Ferenc Jeanplong, Shelley J. Falconer, Mark Thomas, Jenny M. Oldham, Kenneth G. Matthews, Christopher D. McMahon
Publikováno v:
Open Journal of Molecular and Integrative Physiology. :127-138
Growth and differentiation factor-11 (GDF-11) is a secreted protein that is closely related to myostatin, a known inhibitor of skeletal muscle development. The role of GDF-11 in regulating skeletal muscle growth remains unclear and the pattern of exp
Autor:
Kenneth G. Matthews, J J Bass, Ferenc Jeanplong, Shelley J. Falconer, Richard J. Wilkins, Heather K. Smith, John V. Conaglen, Christopher D. McMahon, Claire C. Osepchook, David F. Gerrard, Jenny M. Oldham
Publikováno v:
The Journal of Physiology. 587:669-677
Myostatin inhibits myogenesis and there is reduced abundance of the mature protein in skeletal muscles of adult male compared with female mice. This reduction probably occurs after translation, which suggests that it is a regulated mechanism to reduc
Publikováno v:
Journal of Histochemistry & Cytochemistry. 51:1611-1620
This study tested whether administration of insulin-like growth factor-II (IGF-II) enhances muscle regeneration. Rat biceps femoris muscle was damaged with notexin and then IGF-II was administered for up to 7 days. Results show that the proportion of