Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Jenny Li-Chun Lin"'
Autor:
Douglas B. Cowan, Qing Ma, Kathryn Li, Francisco J. Naya, Haipeng Guo, Yi Wang, Qingchuan Wang, Xiaoyun Hu, Zhiqiang Lin, Jianming Liu, Jan Kyselovic, Hee Young Seok, Da-Zhi Wang, Jenny Li-Chun Lin, Yao Wei Lu, William T. Pu, Zhan-Peng Huang, Yuguo Chen, Jim J.-C. Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Intercalated discs (ICD), specific cell-to-cell contacts that connect adjacent cardiomyocytes, ensure mechanical and electrochemical coupling during contraction of the heart. Mutations in genes encoding ICD components are linked to cardiovascular dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad20cffb5ab62e82d32c2b24f334d96
http://link.springer.com/article/10.1038/s41467-020-18379-8
http://link.springer.com/article/10.1038/s41467-020-18379-8
Autor:
Tiago Fernandes, Francisco J. Naya, Zhiqiang Lin, Yuxuan Guo, Xiaoyun Hu, Jenny Li-Chun Lin, Haipeng Guo, Jim J.-C. Lin, Da-Zhi Wang, Jianming Liu, William T. Pu, Zhan-Peng Huang, Yi Wang, Yao Wei Lu
Publikováno v:
Circulation Research. 125
Cardiovascular diseases continue to be a leading cause of death and disability. Despite this alarming fact, there is lack of effectual treatment and the molecular mechanisms underlying these devastating diseases remain elusive. Intercalated disk (ICD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4f836c25edcfd97aa00d3f16b5b99f9
https://doi.org/10.1161/res.125.suppl_1.919
https://doi.org/10.1161/res.125.suppl_1.919
Publikováno v:
Archives of Biochemistry and Biophysics. 535:91-100
The Xin repeat-containing proteins, Xinα (Xirp1) and Xinβ (Xirp2), localize to the intercalated discs (ICDs) of mammalian hearts. Mouse Xinα (mXinα) directly interacts with β-catenin and actin filaments, potentially coupling the N-cadherin/β-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2608ec07e512049ab544475b38713ce
https://doi.org/10.1016/j.abb.2012.12.018
https://doi.org/10.1016/j.abb.2012.12.018
Autor:
Elisabeth A. Gustafson-Wagner, Chiao Pei Cheng, Kuo Ho Wu, Fu Chi Chan, Chih Hsiung Hsu, Cheng I. Lin, Yao Chang Chen, Jenny Li-Chun Lin, Jim J.-C. Lin, Qinchuan Wang
Publikováno v:
Frontiers in Bioscience. :1425-1442
Mouse Xin-alpha (mXin-alpha) encodes a Xin repeat-containing, actin-binding protein localized to the intercalated disc (ICD). Ablation of mXin-alpha progressively leads to disrupted ICD structure, cardiac hypertrophy and cardiomyopathy with conductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7e74e39a4f01d6d792395958f3f845
https://doi.org/10.2741/e344
https://doi.org/10.2741/e344
Autor:
Thomas D. Scholz, Han Zhong Feng, Cheng I. Lin, Elisabeth A. Gustafson-Wagner, Fu Chi Chan, Jian Ping Jin, Jim J.-C. Lin, Jenny Li-Chun Lin, Baoli Yang, Benjamin E. Reinking, Qinchuan Wang
Publikováno v:
Circulation Research. 106:1468-1478
Rationale : The Xin repeat–containing proteins mXinα and mXinβ localize to the intercalated disc of mouse heart and are implicated in cardiac development and function. The mXinα directly interacts with β-catenin, p120-catenin, and actin filamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932b4b54c978261b93062749c8439a7f
https://doi.org/10.1161/circresaha.109.212787
https://doi.org/10.1161/circresaha.109.212787
Publikováno v:
Cell Motility and the Cytoskeleton. 65:197-215
Myosin Va, an actin-based motor protein that transports intracellular cargos, can bundle actin in vitro. Whether myosin Va regulates cellular actin dynamics or cell migration remains unclear. To address this, we compared Chinese Hamster Ovary (CHO) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8babd3220bb012a4461355de0f10830
https://doi.org/10.1002/cm.20255
https://doi.org/10.1002/cm.20255
Autor:
Shannon M. Harlan, Sunju Choi, Jim J.-C. Lin, Jenny Li-Chun Lin, Qinchuan Wang, Haley W. Sinn, Elisabeth A. Gustafson-Wagner
Publikováno v:
Journal of Biological Chemistry. 282:36024-36036
Targeted deletion of mXinα results in cardiac hypertrophy and cardiomyopathy with conduction defects (Gustafson-Wagner, E., Sinn, H. W., Chen, Y.-L., Wang, D.-Z., Reiter, R. S., Lin, J. L.-C., Yang, B., Williamson, R. A., Chen, J. N., Lin, C.-I., an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba1fd493c6e2f702afb6d9761233ed5
https://doi.org/10.1074/jbc.m707639200
https://doi.org/10.1074/jbc.m707639200
Publikováno v:
Archives of Biochemistry and Biophysics. 456:161-174
The contractile ring and the cell cortex generate force to divide the cell while maintaining symmetrical shape. This requires temporal and spatial regulation of the actin cytoskeleton at these areas. We force-expressed misregulated versions of actin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c36cb31b5d3f561e52fbf746664f9a
https://doi.org/10.1016/j.abb.2006.06.015
https://doi.org/10.1016/j.abb.2006.06.015
Publikováno v:
Cell Motility and the Cytoskeleton. 63:543-562
Caldesmon is believed to be one of the key regulators for actin dynamics and thereby cell polarity, membrane extension, and cell motility. We have shown previously that stress fiber formation and cell movement are severely impaired in the cells expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017cb0f057aa435c46b7c93297906ca
https://doi.org/10.1002/cm.20144
https://doi.org/10.1002/cm.20144
Publikováno v:
Cellular and Molecular Life Sciences (CMLS). 60:198-211
To study the mitosis-specific phosphorylation of caldesmon (CaD), we generated a mutant of the C-terminal fragment (amino acids 244-538) of human fibroblast CaD (CaD39-6F), as well as a mutant of the full-length CaD (CaD-6F), in which all six potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848a22af0d83976efe3fe7ba9de491e9
https://doi.org/10.1007/s000180300014
https://doi.org/10.1007/s000180300014