Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jenny Lazarus"'
Autor:
Brian D. Griffith, Jenny Lazarus, Jake McGue, Santhoshi Krishnan, Michael I. D’Angelica, Jinru Shia, Irina Dobrosotskaya, Jaiqi Shi, Jacob Edwards, Arvind Rao, Timothy L. Frankel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMetastatic colorectal cancer (mCRC) remains a common and highly morbid disease, with a recent increase in incidence in patients younger than 50 years. There is an acute need to better understand differences in tumor biology, molecular cha
Externí odkaz:
https://doaj.org/article/ed68ae9a295e4cebb8bc43b4e0482043
Autor:
Ashley Velez-Delgado, Katelyn L. Donahue, Kristee L. Brown, Wenting Du, Valerie Irizarry-Negron, Rosa E. Menjivar, Emily L. Lasse Opsahl, Nina G. Steele, Stephanie The, Jenny Lazarus, Veerin R. Sirihorachai, Wei Yan, Samantha B. Kemp, Samuel A. Kerk, Murali Bollampally, Sion Yang, Michael K. Scales, Faith R. Avritt, Fatima Lima, Costas A. Lyssiotis, Arvind Rao, Howard C. Crawford, Filip Bednar, Timothy L. Frankel, Benjamin L. Allen, Yaqing Zhang, Marina Pasca di Magliano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 6, Pp 1673-1699 (2022)
Background & Aims: Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. Although the tumor cell–intrinsic effects of onco
Externí odkaz:
https://doaj.org/article/20125fcc27cc45cf89b627da102ba12b
Autor:
Marina Pasca di Magliano, Filip Bednar, Timothy L. Frankel, Costas A. Lyssiotis, Howard C. Crawford, Michelle A. Anderson, Alekya Vinta, Anna C. Nevison, Valerie Irizarry-Negron, Kristee L. Brown, Eileen S. Carpenter, Katelyn Donahue, Ashley Velez-Delgado, Veerin R. Sirihorachai, Samantha B. Kemp, Rosa E. Menjivar, Christopher J. Halbrook, Zeribe C. Nwosu, Ho-Joon Lee, Wei Yan, Nina G. Steele, Jenny Lazarus, Yaqing Zhang
Supplemental figure 1 with legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bde75b91e5ddb41ec4fdc3d131335d2
https://doi.org/10.1158/2159-8290.22535420
https://doi.org/10.1158/2159-8290.22535420
Autor:
Marina Pasca di Magliano, Filip Bednar, Timothy L. Frankel, Costas A. Lyssiotis, Howard C. Crawford, Michelle A. Anderson, Alekya Vinta, Anna C. Nevison, Valerie Irizarry-Negron, Kristee L. Brown, Eileen S. Carpenter, Katelyn Donahue, Ashley Velez-Delgado, Veerin R. Sirihorachai, Samantha B. Kemp, Rosa E. Menjivar, Christopher J. Halbrook, Zeribe C. Nwosu, Ho-Joon Lee, Wei Yan, Nina G. Steele, Jenny Lazarus, Yaqing Zhang
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To understand the contribution to the immunosuppressive microenvironment, we depleted Tregs in a mouse model of pancreatic cancer. Contrary to our expectations, Treg depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2302b85563ad76a36772a8aff5c74104
https://doi.org/10.1158/2159-8290.c.6547853.v1
https://doi.org/10.1158/2159-8290.c.6547853.v1
Autor:
Meredith A. Morgan, Weiping Zou, Theodore S. Lawrence, Yu L. Lei, Ilona Kryczek, Timothy L. Frankel, Marina Pasca di Magliano, Daniel R. Wahl, Nithya Ramnath, Jiaqi Shi, Leslie A. Parsels, Shuang Wei, Joshua D. Parsels, Jenny Lazarus, Xueting Lang, Michael D. Green, Qiang Zhang
SF1: ATM regulates type I interferon signaling in pancreatic cancer. SF2: ATM regulation of the type I interferon pathway is cGAS/STING independent but SRC dependent. SF3: ATM inhibition cooperates with radiation to activate type I interferon signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01dbd85b612376ffe2dd4ba3f44dadf3
https://doi.org/10.1158/0008-5472.22421315.v1
https://doi.org/10.1158/0008-5472.22421315.v1
Autor:
Meredith A. Morgan, Weiping Zou, Theodore S. Lawrence, Yu L. Lei, Ilona Kryczek, Timothy L. Frankel, Marina Pasca di Magliano, Daniel R. Wahl, Nithya Ramnath, Jiaqi Shi, Leslie A. Parsels, Shuang Wei, Joshua D. Parsels, Jenny Lazarus, Xueting Lang, Michael D. Green, Qiang Zhang
Combinatorial strategies are needed to overcome the resistance of pancreatic cancer to immune checkpoint blockade (ICB). DNA damage activates the innate immune response and improves ICB efficacy. Because ATM is an apical kinase in the radiation-induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a5766108e3142dc0311560c9d33e96
https://doi.org/10.1158/0008-5472.c.6510890.v1
https://doi.org/10.1158/0008-5472.c.6510890.v1
Autor:
Meredith A. Morgan, Weiping Zou, Theodore S. Lawrence, Yu L. Lei, Ilona Kryczek, Timothy L. Frankel, Marina Pasca di Magliano, Daniel R. Wahl, Nithya Ramnath, Jiaqi Shi, Leslie A. Parsels, Shuang Wei, Joshua D. Parsels, Jenny Lazarus, Xueting Lang, Michael D. Green, Qiang Zhang
SF1 Legend: ATM regulates type I interferon signaling in pancreatic cancer. SF2 Legend: ATM regulation of the type I interferon pathway is cGAS/STING independent but SRC dependent. SF3 Legend: ATM inhibition cooperates with radiation to activate type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044dbd07fbdd38f097b38c48e2b82cbc
https://doi.org/10.1158/0008-5472.22421312
https://doi.org/10.1158/0008-5472.22421312
Autor:
Brian D. Griffith, Simon Turcotte, Jenny Lazarus, Fatima Lima, Samantha Bell, Lawrence Delrosario, Jake McGue, Santhoshi Krishnan, Morgan D. Oneka, Hari Nathan, J. Joshua Smith, Michael I. D’Angelica, Jinru Shia, Marina Pasca Di Magliano, Arvind Rao, Timothy L. Frankel
Publikováno v:
Cancers; Volume 14; Issue 17; Pages: 4092
Despite advances in therapy over the past decades, metastatic colorectal cancer (mCRC) remains a highly morbid disease. While the impact of MHC-I on immune infiltration in mCRC has been well studied, data on the consequences of MHC-II loss are lackin
Autor:
Nina G. Steele, Eileen S. Carpenter, Samantha B. Kemp, Veerin R. Sirihorachai, Stephanie The, Lawrence Delrosario, Jenny Lazarus, El-ad David Amir, Valerie Gunchick, Carlos Espinoza, Samantha Bell, Lindsey Harris, Fatima Lima, Valerie Irizarry-Negron, Daniel Paglia, Justin Macchia, Angel Ka Yan Chu, Heather Schofield, Erik-Jan Wamsteker, Richard Kwon, Allison Schulman, Anoop Prabhu, Ryan Law, Arjun Sondhi, Jessica Yu, Arpan Patel, Katelyn Donahue, Hari Nathan, Clifford Cho, Michelle A. Anderson, Vaibhav Sahai, Costas A. Lyssiotis, Weiping Zou, Benjamin L. Allen, Arvind Rao, Howard C. Crawford, Filip Bednar, Timothy L. Frankel, Marina Pasca di Magliano
Publikováno v:
Nat Cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by an immune-suppressive tumor microenvironment that renders it largely refractory to immunotherapy. We implemented a multimodal analysis approach to elucidate the immune landscape in PDA. Using
Autor:
Veerin Sirihorachai, Wei Yan, Nina Steele, Marina Pasca di Magliano, Ashley Velez-Delgado, Costas A. Lyssiotis, Rosa E. Menjivar, Samantha Kemp, Jenny Lazarus, Yaqing Zhang, Michelle A. Anderson, Filip Bednar, Anna C. Nevison, Timothy L. Frankel, Alekya Vinta, Kristee Brown, Katelyn Donahue, Howard C. Crawford, Eileen S. Carpenter, Valerie Irizarry-Negron, Ho-Joon Lee, Christopher J. Halbrook, Zeribe C. Nwosu
Publikováno v:
Cancer discovery, vol 10, iss 3
Cancer Discov
Cancer Discov
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To understand the contribution to the immunosuppressive microenvironment, we depleted Tregs in a mouse model of pancreatic cancer. Contrary to our expectations, Treg depleti