Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Jenny L Persson"'
Autor:
Tianyan Wang, Martuza Sarwar, Jonathan B Whitchurch, Hilary M Collins, Tami Green, Julius Semenas, Amjad Ali, Christopher J Roberts, Ryan D Morris, Madlen Hubert, Sa Chen, Zahra El-Schich, Anette G Wingren, Thomas Grundström, Richard Lundmark, Nigel P Mongan, Lena Gunhaga, David M Heery, Jenny L Persson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
PIP5K1α has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling pathway to promote prostate cancer (PCa) growth, survival and invasion. However, little is
Externí odkaz:
https://doaj.org/article/6f00bee0afbc4bf1a1d8d8f354c3e273
Autor:
Torben Redmer, Martin Raigel, Christina Sternberg, Roman Ziegler, Clara Probst, Desiree Lindner, Astrid Aufinger, Tanja Limberger, Karolina Trachtova, Petra Kodajova, Sandra Högler, Michaela Schlederer, Stefan Stoiber, Monika Oberhuber, Marco Bolis, Heidi A. Neubauer, Sara Miranda, Martina Tomberger, Nora S. Harbusch, Ines Garces de los Fayos Alonso, Felix Sternberg, Richard Moriggl, Jean-Philippe Theurillat, Boris Tichy, Vojtech Bystry, Jenny L. Persson, Stephan Mathas, Fritz Aberger, Birgit Strobl, Sarka Pospisilova, Olaf Merkel, Gerda Egger, Sabine Lagger, Lukas Kenner
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-21 (2024)
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated as potential oncogeni
Externí odkaz:
https://doaj.org/article/adefb22c8cb94d6696ce31c1da5a32f5
Autor:
Rodhan Patke, Anna E. Harris, Corinne L. Woodcock, Rachel Thompson, Rute Santos, Amber Kumari, Cinzia Allegrucci, Nathan Archer, Lorraine J. Gudas, Brian D. Robinson, Jenny L. Persson, Rupert Fray, Jennie Jeyapalan, Catrin S. Rutland, Emad Rakha, Srinivasan Madhusudan, Richard D. Emes, Musalwa Muyangwa-Semenova, Mansour Alsaleem, Simone de Brot, William Green, Hari Ratan, Nigel P. Mongan, Jennifer Lothion-Roy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 56, Iss , Pp 101032- (2024)
Prostate cancer (PCa) is the second most common cancer diagnosed in men. While radical prostatectomy and radiotherapy are often successful in treating localised disease, post-treatment recurrence is common. As the androgen receptor (AR) and androgen
Externí odkaz:
https://doaj.org/article/f224ca60609a48d0bd38942bd1a03543
Autor:
Eric Toh, Palwasha Baryalai, Aftab Nadeem, Kyaw Min Aung, Sa Chen, Karina Persson, Jenny L. Persson, Bernt Eric Uhlin, Sun Nyunt Wai
Publikováno v:
Cell Death and Disease, Vol 13, Iss 12, Pp 1-13 (2022)
Abstract Recently, we demonstrated that a novel bacterial cytotoxin, the protein MakA which is released by Vibrio cholerae, is a virulence factor, causing killing of Caenorhabditis elegans when the worms are grazing on the bacteria. Studies with mamm
Externí odkaz:
https://doaj.org/article/a2f7425267624f9f8bee494f52b390c5
Autor:
Per Flodbring Larsson, Richard Karlsson, Martuza Sarwar, Regina Miftakhova, Tianyan Wang, Azharuddin Sajid Syed Khaja, Julius Semenas, Sa Chen, Andreas Hedblom, Amjad Ali, Kristina Ekström‐Holka, Athanasios Simoulis, Anjani Kumar, Anette Gjörloff Wingren, Brian Robinson, Sun Nyunt Wai, Nigel P. Mongan, David M. Heery, Daniel Öhlund, Thomas Grundström, Niels Ødum, Jenny L. Persson
Publikováno v:
Molecular Oncology, Vol 16, Iss 13, Pp 2496-2517 (2022)
Low‐affinity immunoglobulin gamma Fc region receptor III‐A (FcγRIIIa) is a cell surface protein that belongs to a family of Fc receptors that facilitate the protective function of the immune system against pathogens. However, the role of FcγRII
Externí odkaz:
https://doaj.org/article/b9424d66238242208aa13b376f19daab
Autor:
Veronika M. Metzler, Simone de Brot, Daisy B. Haigh, Corinne L. Woodcock, Jennifer Lothion-Roy, Anna E. Harris, Emeli M. Nilsson, Atara Ntekim, Jenny L. Persson, Brian D. Robinson, Francesca Khani, Kristian B. Laursen, Lorraine J. Gudas, Michael S. Toss, Srinivasan Madhusudan, Emad Rakha, David M. Heery, Catrin S. Rutland, Nigel P. Mongan, Jennie N. Jeyapalan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types
Externí odkaz:
https://doaj.org/article/a03a643cd6764996be2ac0f2c2df949e
Autor:
Anna E. Harris, Veronika M. Metzler, Jennifer Lothion-Roy, Dhruvika Varun, Corinne L. Woodcock, Daisy B. Haigh, Chantelle Endeley, Maria Haque, Michael S. Toss, Mansour Alsaleem, Jenny L. Persson, Lorraine J. Gudas, Emad Rakha, Brian D. Robinson, Francesca Khani, Laura M. Martin, Jenna E. Moyer, Juliette Brownlie, Srinivasan Madhusudan, Cinzia Allegrucci, Victoria H. James, Catrin S. Rutland, Rupert G. Fray, Atara Ntekim, Simone de Brot, Nigel P. Mongan, Jennie N. Jeyapalan
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Androgen deprivation therapies (ADTs) are important treatments which inhibit androgen-induced prostate cancer (PCa) progression by either preventing androgen biosynthesis (e.g. abiraterone) or by antagonizing androgen receptor (AR) function (e.g. bic
Externí odkaz:
https://doaj.org/article/cdc6c0e64c544575b4a2feb180c39250
Autor:
Julius Semenas, Tianyan Wang, Azharuddin Sajid Syed Khaja, AKM Firoj Mahmud, Athanasios Simoulis, Thomas Grundström, Maria Fällman, Jenny L. Persson
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 968-986 (2021)
Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration‐resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor ERα due to androgen deprivation thera
Externí odkaz:
https://doaj.org/article/76e6e359dd224187a7177058d52aa91f
Autor:
Heather Johnson, Jinan Guo, Xuhui Zhang, Heqiu Zhang, Athanasios Simoulis, Alan H. B. Wu, Taolin Xia, Fei Li, Wanlong Tan, Allan Johnson, Nishtman Dizeyi, Per-Anders Abrahamsson, Lukas Kenner, Xiaoyan Feng, Chang Zou, Kefeng Xiao, Jenny L. Persson, Lingwu Chen
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background Heterogeneity of prostate cancer (PCa) contributes to inaccurate cancer screening and diagnosis, unnecessary biopsies, and overtreatment. We intended to develop non-invasive urine tests for accurate PCa diagnosis to avoid unnecess
Externí odkaz:
https://doaj.org/article/e9f569944add4c5fa59d804e2aada290
Autor:
Marek Feith, Yuecheng Zhang, Jenny L. Persson, Jan Balvan, Zahra El-Schich, Anette Gjörloff Wingren
Publikováno v:
Photonics, Vol 9, Iss 12, p 955 (2022)
Colorectal cancer (CRC) is the second most metastatic disease with the majority of cases detected in Western countries. Metastases are formed by circulating altered phenotype tumor cells causing 20% of CRC related deaths. Metastatic cells may show hi
Externí odkaz:
https://doaj.org/article/5b8574ed38414a39a7f0bafcdbb938d4