Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jenny Kung"'
Autor:
Hanh H. Nguyen, Crystal N. Marconett, David H. Nguyen, Maria N. Preobrazhenskaya, Min Tseng, Leonard F. Bjeldanes, Richard E. Staub, Jenny Kung, S. N. Lavrenov, Gary L. Firestone, Shyam N. Sundar
Publikováno v:
Chemico-Biological Interactions. 186:255-266
Indole-3-carbinol (I3C), a natural autolysis product of a gluccosinolate present in Brassica vegetables such as broccoli and cabbage, has anti-proliferative and anti-estrogenic activities in human breast cancer cells. A new and significantly more pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e23304fcb69bc8da2317f7b0c75dd
https://doi.org/10.1016/j.cbi.2010.05.015
https://doi.org/10.1016/j.cbi.2010.05.015
Autor:
Leonard F. Bjeldanes, Maria N. Preobrazhenskaya, Matthew A. Kinseth, L. N. Yudina, Richard E. Staub, Sarah M. Jump, Erin J. Cram, Gary L. Firestone, Jenny Kung
Publikováno v:
Biochemical Pharmacology. 75:713-724
Indole-3-carbinol (I3C), a naturally occurring component of Brassica vegetables, such as cabbage, broccoli, and Brussels sprouts, induces a G1 cell cycle arrest of human breast cancer cells. Structure-activity relationships of I3C that mediate this a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22dd4febc9a085b5ce76f8c333b49d92
https://doi.org/10.1016/j.bcp.2007.09.024
https://doi.org/10.1016/j.bcp.2007.09.024
Publikováno v:
Biochemistry. 44:7704-7712
The fluorogenic reagent 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABDF) attenuates the functional activity of the protein tyrosine phosphatase PTP1B by reacting selectively with a single cysteine residue, leaving other cysteines in the protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbd70060c41af4cce22abead3e8d31d
https://doi.org/10.1021/bi047417s
https://doi.org/10.1021/bi047417s
Autor:
Stig Hansen, Jenny Kung, Lisa Taylor, Kenneth J. Barr, Mike Randal, Daniel A. Erlanson, Robert S. McDowell, Christian Wiesmann, Min Zhong, Wang Shen, Jiang Zhu, Bruce Fahr
Publikováno v:
Nature Structural & Molecular Biology. 11:730-737
Obesity and type II diabetes are closely linked metabolic syndromes that afflict >100 million people worldwide. Although protein tyrosine phosphatase 1B (PTP1B) has emerged as a promising target for the treatment of both syndromes, the discovery of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03d1388952a21ac3e1df66a605ff322
https://doi.org/10.1038/nsmb803
https://doi.org/10.1038/nsmb803
Autor:
Molly M. He, Jenny Kung, Stig Hansen, Daniel A. Erlanson, Robert S. McDowell, Andrew B. Waight, Mike Randal, Robert Lowell Simmons
Publikováno v:
Journal of the American Chemical Society. 125:5602-5603
Protein tyrosine phosphatases play important roles in many signaling cascades involved in human disease. The identification of druglike inhibitors for these targets is a major challenge, and the discovery of suitable phosphotyrosine (pY) mimetics rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c7a4e0aae939fb22eff67aabed2427
https://doi.org/10.1021/ja034440c
https://doi.org/10.1021/ja034440c