Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging

Autor: Jenny K. Ngo, Laura C.D. Pomatto, Kelvin J.A. Davies

Publikováno v: Redox Biology, Vol 1, Iss 1, Pp 258-264 (2013)

The elimination of oxidatively modified proteins is a crucial process in maintaining cellular homeostasis, especially during stress. Mitochondria are protein-dense, high traffic compartments, whose polypeptides are constantly exposed to superoxide, h

Externí odkaz: https://doaj.org/article/c9bcd188b8594f188fc47d8277fd224e

Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training

Autor: Sataro Goto, Erika Koltai, Albert W. Taylor, Zsolt Radak, Jenny K. Ngo, Kelvin J.A. Davies, Nikolett Hart

Publikováno v: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303:R127-R134

A decline in mitochondrial biogenesis and mitochondrial protein quality control in skeletal muscle is a common finding in aging, but exercise training has been suggested as a possible cure. In this report, we tested the hypothesis that moderate-inten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2850b06141ee33e4cf53ff09b42faf87
https://doi.org/10.1152/ajpregu.00337.2011

Impairment of Lon-Induced Protection Against the Accumulation of Oxidized Proteins in Senescent Wi-38 Fibroblasts

Autor: Daniela A. Bota, Kelvin J.A. Davies, Jenny K. Ngo, Alison L. Koop, Laura C.D. Pomatto

Publikováno v: Ngo, Jenny K; Pomatto, Laura CD; Bota, Daniela A; Koop, Alison L; & Davies, Kelvin JA. (2011). Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts.. The journals of gerontology. Series A, Biological sciences and medical sciences, 66(11), 1178-1185. doi: 10.1093/gerona/glr145. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/6695c9sw

Oxidative damage to mitochondrial proteins is thought to contribute to the aging process, but the Lon protease normally degrades such proteins. In early-passage WI-38 human lung fibroblasts, Lon expression is rapidly induced during H(2)O(2) stress, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0e9b331dbbe0c8b1873a16a73c6705
https://doi.org/10.1093/gerona/glr145

Mitochondrial Lon protease is a human stress protein

Autor: Kelvin J.A. Davies, Jenny K. Ngo

Publikováno v: Free radical biologymedicine. 46(8)

The targeted removal of damaged proteins by proteolysis is crucial for cell survival. We have shown previously that the Lon protease selectively degrades oxidized mitochondrial proteins, thus preventing their aggregation and cross-linking. We now sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a69ed4818a9ab9e375f0bc533e1555
https://pubmed.ncbi.nlm.nih.gov/19439239

Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death

Autor: Kelvin J.A. Davies, Jenny K. Ngo, Daniela A. Bota

Publikováno v: Bota, Daniela A; Ngo, Jenny K; & Davies, Kelvin JA. (2005). Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death.. Free radical biology & medicine, 38(5), 665-677. doi: 10.1016/j.freeradbiomed.2004.11.017. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/3348s0gq

Lon now emerges as a major regulator of multiple mitochondrial functions in human beings. Lon catalyzes the degradation of oxidatively modified matrix proteins, chaperones the assembly of inner membrane complexes, and participates in the regulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f097c2d34ab18f83db68ef1988a0248f
http://www.escholarship.org/uc/item/3348s0gq