Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Jenny J. Zhang"'
Publikováno v:
The International Journal of Biostatistics. 17:99-115
Progression-free survival (PFS), defined as the time from randomization to progression of disease or death, has been indicated as an endpoint to support accelerated approval of certain cancer drugs by the U.S. FDA. The standard Kaplan–Meier (KM) es
Autor:
Shenghui Tang, Rajeshwari Sridhara, Robert Justice, Huanyu Chen, Richard Pazdur, Jenny J. Zhang, Patricia Keegan, Kun He
Publikováno v:
Therapeutic innovationregulatory science. 47(2)
Use of blinded independent central review (BICR) has become more common in oncology phase 3 trials as progression-free survival (PFS) has been increasingly used as an endpoint for regulatory approval. Since PFS is primarily a radiographic endpoint, B
Publikováno v:
Nephron. 129:29-33
Background: Most patients with diabetic kidney disease (DKD) experience disease progression despite receiving standard care therapy. Oxidative stress is associated with DKD severity and risk of progression, but currently approved therapies do not dir
Autor:
Ricardo A. Cruciani, Jenny J. Zhang, David Cella, Bilal Ansari, Judith Manola, Michael J. Fisch
Publikováno v:
Journal of Clinical Oncology. 30:3864-3869
Purpose L-carnitine, a popular complementary and alternative medicine product, is used by patients with cancer for the treatment of fatigue, the most commonly reported symptom in this patient population. The purpose of this study was to determine the
Autor:
Robert Justice, Shenghui Tang, Rajeshwari Sridhara, Gideon M. Blumenthal, Anthony J. Murgo, Jenny J. Zhang, Richard Pazdur, Patricia Cortazar
Publikováno v:
The Oncologist. 17:1108-1113
On May 20, 2011, the U.S. Food and Drug Administration (FDA) approved sunitinib malate capsules (Sutent®; Pfizer, Inc., New York) for the treatment of progressive, well-differentiated pancreatic neuroendocrine tumors (pNETs) in patients with unresec
Autor:
Rupika S. Rajakaruna, Rachel F. Daniels, Flemming Konradsen, Priyanie H. Amerasinghe, Dyann F. Wirth, Jenny J. Zhang, Nadira D. Karunaweera, Michael Alifrangis, Tharanga N. Senaratne, Clarissa Valim
Publikováno v:
The American Journal of Tropical Medicine and Hygiene. 85:811-814
Widespread antimalarial resistance has been a barrier to malaria elimination efforts in Sri Lanka. Analysis of genetic markers in historic parasites may uncover trends in the spread of resistance. We examined the frequency of Plasmodium falciparum ch
Autor:
Jianliang Zhang, Jenny J. Zhang
Publikováno v:
Journal of Biopharmaceutical Statistics. 21:125-135
This paper discusses multiple-to-one comparison trials testing a multivalent vaccine product against multiple comparators with respect to immunologic responses. An optimal subject allocation ratio between the multivalent vaccine group and any of the
Autor:
Jenny J. Zhang, Molin Wang
Publikováno v:
Biometrical Journal. 51:932-945
We extend the Dahlberg and Wang (Biometrics 2007, 63, 1237–1244) proportional hazards (PH) cure model for the analysis of time-to-event data that is subject to a cure rate with masked event to a setting where the PH assumption does not hold. Assumi
Publikováno v:
Journal of Cellular Physiology. 210:527-537
Platelet endothelial cell adhesion molecule-1 (PECAM-1) (CD31) is known to inhibit platelet function and thrombus formation. The mechanisms involved in PECAM-1's roles as a modulator of hemostasis are still not completely understood. We examined the
Publikováno v:
Human Gene Therapy. 11:1817-1827
73 Adrenomedullin (AM) is a potent vasodilator expressed in tissues relevant to cardiac and renal functions. Our previous study showed that delivery of the human AM gene in the form of naked DNA caused a prolonged reduction of blood pressure in genet