Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jenny J. L. Ho"'
Autor:
Fiona J. Coutinho, Lilian Lee, Robert Vanner, Marco Gallo, Ian D. Clarke, Erick Ling, Peter B. Dirks, Jenny J. L. Ho, Renee Head
Publikováno v:
Cancer Research. 73:417-427
Glioblastoma growth is driven by cancer cells that have stem cell properties, but molecular determinants of their tumorigenic behavior are poorly defined. In cancer, altered activity of the epigenetic modifiers Polycomb and Trithorax complexes may co
Autor:
Shih-Fan Kuan, Grace E. Kim, Jenny J. L. Ho, Hee Ug Park, Suzanne C. Crawley, Han Ik Bae, Young S. Kim
Publikováno v:
Gastroenterology. 123:1052-1060
Background & Aims: It has recently been suggested that infiltrating adenocarcinoma of the pancreas arises from histologically well-defined precursor ductal lesions called pancreatic intraepithelial neoplasia (PanIN-1A, -1B, -2, and -3). This study ex
Autor:
Wendy S. Pratt, James R. Gum, James W. Hicks, Suzanne C. Crawley, Dallas M. Swallow, Jenny J. L. Ho, Matthew W Nash, Young S. Kim
Publikováno v:
Biochemical and Biophysical Research Communications. 275:916-923
The MUC3 gene encodes a transmembrane mucin-type glycoprotein. A number of consistent single nucleotide changes were observed in different MUC3 cDNAs from a single individual, suggesting the presence of at least three different transcripts per indivi
Autor:
Atsushi Yamamoto, Tetsuji Sawada, Kosei Hirakawa-YS Chung, Tamahiro Nishihara, Yoshito Yamashita, Young-Sik Kim, Jenny J. L. Ho
Publikováno v:
Japanese Journal of Cancer Research : Gann
In a previous study, mouse monoclonal antibody (MoAb) Nd2 (m-Nd2, mouse IgG1) labeled with (131)I exhibited efficacy in in vivo radioimmunotherapy against pancreatic cancer. In this study we prepared mouse / human chimeric antibody Nd2 (c-Nd2, human
Publikováno v:
European Journal of Cancer. 36:113-120
The carbohydrate antigen sialyl-Lewis a is important to pancreatic tumour biology because the circulating antigen is used in serological tests for malignancy and because cell surface antigen is involved in tumour cell binding to the endothelial adhes
Autor:
Hironobu Ochi, Tetsuji Sawada, Kosei Hirakawa, Jenny J. L. Ho, Hitoshi Teraoka, Tamahiro Nishihara, Terue Okamura, Atsushi Yamamoto, Young-Sik Kim, Yoshito Yamashita
Publikováno v:
Japanese Journal of Cancer Research : Gann
The present study was carried out with the purpose of evaluating the clinical usefulness of radioimmunodetection (RAID) with 111 In-labeled murine/human chimeric monoclonal antibody, Nd2 (c-Nd2) in patients with pancreatic cancer. Nineteen patients s
Publikováno v:
Annals of Oncology. 10:S51-S55
Mucins are high molecular weight glycoproteins which are heavily glycosylated with many carbohydrate side chains. In epithelial cancers such as biliopancreatic cancer, both quantitative and qualitative alterations in carbohydrate and polypeptide moie
Autor:
Jenny J. L. Ho, Young S. Kim
Publikováno v:
Annals of Oncology. 10:S300-S304
Summary Several key areas are targeted by novel therapies. Growth factors and their receptors are overexpressed in a high percentage of pancreatic tumors. These factors are critical to tumor cell growth and development. They also promote tumor growth
Autor:
James R. Gum, Alexander S. Hill, Jenny J. L. Ho, Wendy S. Pratt, Young S. Kim, Lynne E. Vinall, James W. Hicks, Dallas M. Swallow, Anthony M. Roberton
Publikováno v:
Journal of Biological Chemistry. 272:26678-26686
MUC3 is a large mucin glycoprotein expressed by the human intestine and gall bladder. In this manuscript, we present details of the deduced protein structure of MUC3. The MUC3 carboxyl-terminal domain is 617 residues in length, including 511 residues
Autor:
Sandra Cheng, Yoshito Yamashita, Michio Sowa, Jenny J. L. Ho, Yong-Suk Chung, Young S. Kim, Bader Siddiki
Publikováno v:
International Journal of Cancer. 72:457-466
Mucin-associated sialylated Lewis antigens are implicated in tumor cell metastasis and are used in several tests for pancreatic cancer. Despite their clinical importance, little is known about the structures of the oligosaccharides of pancreatic canc