Výsledky vyhledávání - "Jenny I.O. Craig"

Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

Autor: Thaidy Moreno, Jonathan Stephens, Charles Crawley, Carolyn Grove, Ignacio Varela, Duncan R. Forsyth, Joanna Baxter, Naomi Park, Roland Rad, Thomas McKerrell, Hannes Ponstingl, Jenny I.O. Craig, Michael A. Scott, Eleftheria Zeggini, Willem H. Ouwehand, Michael A. Quail, George S. Vassiliou, Clare Hodkinson

Publikováno v: Cell Reports, Vol 10, Iss 8, Pp 1239-1245 (2015)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports
Cell Reports. 2015 Mar 3;10(8):1239-45
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

Summary Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation hot spots in blood DNA from 4,219 individuals using ultra-deep sequenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdbeb5dd214c3471a2c5717f8b0d6910
http://www.sciencedirect.com/science/article/pii/S2211124715001138

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Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma

Autor: Kristian M. Bowles, Jenny I.O. Craig, Stuart A. Rushworth, Lyubov Zaitseva, Martin J. Auger, Megan Y. Murray, David J. MacEwan

Multiple Myeloma (MM) is a haematologic malignancy characterized by the accumulation of clonal plasma cells in the bone marrow. Over the last 10-15 y the introduction of the proteasome-inhibitor bortezomib has improved MM prognosis, however relapse d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ac3502f5af283c1ab80b7ffff4ce26
https://europepmc.org/articles/PMC4613153/

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Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol

Autor: Charles Crawley, Carolyn Grove, Nicla Manes, Peter J. Campbell, Gunes Gundem, Naomi Park, Jenny I.O. Craig, Elli Papaemmanuil, Thomas McKerrell, Paul Costeas, Niccolo Bolli, Michael A. Quail, George S. Vassiliou, Ignacio Varela, V. Sathiaseelan, Jianxiang Chi, Bram Herman, Natalie Conte

Publikováno v: Haematologica. 2015 Feb;100(2):214-22
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)

Prognostic stratification is critical for making therapeutic decisions and maximizing survival of patients with acute myeloid leukemia. Advances in the genomics of acute myeloid leukemia have identified several recurrent gene mutations whose prognost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d08da7279ea3132681bc9d2067c92c5
http://hdl.handle.net/10902/9812

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Synthesis of osteoprotegerin and RANKL by megakaryocytes is modulated by oestrogen

Autor: Jenny I.O. Craig, D.C. Ireland, Juliet E. Compston, S. Bord, Michael A. Scott, Emma Frith

Publikováno v: British Journal of Haematology. 126:244-251

To investigate the mechanisms by which megakaryocytes (MKs) may influence bone remodelling, CD34(+) cells were cultured for 6, 9 and 12 d with or without 17beta-oestradiol (E) and immunolocalized for osteoprotegerin (OPG), receptor activator of nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b33ef8fddb7d1c39524c600a9ee4696
https://doi.org/10.1111/j.1365-2141.2004.05024.x

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Estrogen stimulates differentiation of megakaryocytes and modulates their expression of estrogen receptors ? and ?

Autor: Emma Frith, Jenny I.O. Craig, Juliet E. Compston, Michael A. Scott, D.C. Ireland, S. Bord

Publikováno v: Journal of Cellular Biochemistry. 92:249-257

Estrogen has multifunctional effects influencing growth, differentiation, and function in many tissues. High-dose estrogen has been shown to produce anabolic skeletal effects in the skeleton of postmenopausal women with increased megakaryocyte (MK) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a14e77951b9ac5552a0c5bd56ab67db
https://doi.org/10.1002/jcb.20035

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P266 Outcomes from the introduction of fungal biomarkers to the neutropenic fever pathway in a tertiary haematology department

Autor: Charles Crawley, P. Krishnamurthy, D Enoch, George A. Follows, CR Sander, B. Uttenthal, Judith Babar, Jenny I.O. Craig, S Aliyu, R Swayne

Publikováno v: Thorax. 71:A232-A233

Background Invasive fungal disease (IFD) frequently occurs in febrile neutropenic haemato-oncology patients (NHP). Until 2012 no biomarkers were available for the diagnosis of IFD in our Trust. The neutropenic fever pathway was modified to include se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84fc1f23116ae92e59560242d0ad9604
https://doi.org/10.1136/thoraxjnl-2016-209333.409

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Invasive fungal sinusitis in patients treated with fludarabine

Autor: David A Enoch, Jenny I.O. Craig, James S Cargill, Emma Gudgin, Sandra Young Min, Hugo A. Ludlam, Robert E. Marcus, Charles Crawley, Tony Todd, George A. Follows, Pat Sartori, Martin Besser

Publikováno v: Journal of Infection. 56:156-158

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58db083e3326f9550a5d1dbaef04f9ee
https://doi.org/10.1016/j.jinf.2007.11.002

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In situ thrombolysis for cerebral venous thrombosis complicating anti-leukemic therapy

Autor: J. Nicholas Higgins, Jenny I.O. Craig, Anna L. Godfrey, George S. Vassiliou, Philip A. Beer

Publikováno v: Leukemia research. 35(8)

A 23-year-old woman was treated for precursor B acute lymhoblastic leukemia with favorable risk cytogenetics, on the UKALL 003 protocol [1]. She achieved complete morphological and ytogenetic remission after induction therapy (regimen B), with n unco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767b1e546275933f8c38ddb5f9af269f
https://pubmed.ncbi.nlm.nih.gov/21444111

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Contributors

Autor: Albiruni Ryan Abdul Razak, Chris Allen, Brian J. Angus, Jeffrey K. Aronson, Andrew W. Bradbury, Leslie Burnett, Mark Byers, Nicki Colledge, Jane D. Collier, Jenny I.O. Craig, Allan D. Cumming, Graham G. Dark, Martin Dennis, David H. Dockrell, Michael Doherty, Michael John Field, Miles Fisher, David R. FitzPatrick, Brian M. Frier, Jane Goddard, Ian S. Grant, Neil Robert Grubb, Phil Hanlon, Richard P. Hobson, J. Alastair Innes, Stephen M. Lawrie, Christian J. Lueck, D.B.L. McClelland, Helen Macdonald, Sara E. Marshall, David E. Newby, Graham R. Nimmo, Simon I.R. Noble, David R. Oxenham, Kelvin R. Palmer, Ian D. Penman, Stuart H. Ralston, Jonathan L. Rees, Peter T. Reid, Olivia M.V. Schofield, Gordon R. Scott, Jonathan R. Seckl, Michael C. Sharpe, Laurence H. Stewart, Peter Stewart, Mark W.J. Strachan, David R. Sullivan, Shyam Sundar, Simon H.L. Thomas, Neil Turner, Brian R. Walker, Simon R. Walker, Henry G. Watson, George Webster, Julian White, Ed Wilkins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e59a4fa80931d129dbe062069a6c74c
https://doi.org/10.1016/b978-0-7020-3085-7.00038-9

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Entonox as a sedative for bone marrow aspiration and biopsy

Autor: Jenny I.O. Craig, E. J. Gudgin, Martin Besser

Publikováno v: International journal of laboratory hematology. 30(1)

Bone marrow aspiration and biopsy can be a painful procedure. Sedation techniques may make this investigation more acceptable to patients, but have the potential to cause life-threatening complications, as well as requiring additional staff and equip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b991ae0cbb368a8a48dfdfb5eea81a4
https://pubmed.ncbi.nlm.nih.gov/18190470

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