Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

Autor: Zachary Freyberg, Mark S. Sonders, Jenny I. Aguilar, Takato Hiranita, Caline S. Karam, Jorge Flores, Andrea B. Pizzo, Yuchao Zhang, Zachary J. Farino, Audrey Chen, Ciara A. Martin, Theresa A. Kopajtic, Hao Fei, Gang Hu, Yi-Ying Lin, Eugene V. Mosharov, Brian D. McCabe, Robin Freyberg, Kandatege Wimalasena, Ling-Wei Hsin, Dalibor Sames, David E. Krantz, Jonathan L. Katz, David Sulzer, Jonathan A. Javitch

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)

Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine pack

Externí odkaz: https://doaj.org/article/3b8bfbbdbb454af19a8c38df694cd7dd

A network of phosphatidylinositol (4,5)-bisphosphate (PIP2) binding sites on the dopamine transporter regulates amphetamine behavior in Drosophila Melanogaster

Autor: Aparna Shekar, Andrea N Belovich, Samuel J. Mabry, Jenny I. Aguilar, Mary Hongying Cheng, Aurelio Galli, Heinrich J.G. Matthies, Daniele Zanella, Ivet Bahar, James D. Foster, Peter J. Hamilton, Daniel J. Stanislowski

Publikováno v: Mol Psychiatry

Reward modulates the saliency of a specific drug exposure and is essential for the transition to addiction. Numerous human PET–fMRI studies establish a link between midbrain dopamine (DA) release, DA transporter (DAT) availability, and reward respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acb3023906ef59bac4648f34163f922
https://doi.org/10.1038/s41380-019-0620-0

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease

Autor: Kevin Erreger, Mattias Rickhag, Leonie P. Posselt, Aparna Shekar, Aurelio Galli, Troels Rahbek-Clemmensen, Markus Nowak Lonsdale, Sasha Tolstoy, Annemette Løkkegaard, Amy Hauck Newman, Natascha V. Arends, Andreas T. Sørensen, Thomas Werge, Viktor K. Lund, Lisbeth Birk Møller, Jenny I. Aguilar, Ulrik Gether, Kathrine L. Jensen, Lena Elisabeth Hjermind, Matthew D. Lycas, Ole Kjaerulff, Heinrich J.G. Matthies, Freja Herborg

Publikováno v: JCI Insight
Herborg, F, Jensen, K L, Tolstoy, S, Arends, N, Posselt, L P, Shekar, A, Aguilar, J, Lund, V K, Erreger, K, Rickhag, M, Lycas, M D, Lonsdale, M N, Rahbek-Clemmensen, T, Sorensen, A T, Newman, A H, Lokkegaard, A, Kjaerulff, O, Werge, T, Moller, L B, Matthies, H J G, Galli, A, Hjermind, L E, Gether, U & IPSYCH Researchers 2021, ' Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease ', JCI insight, vol. 6, no. 18, 151496 . https://doi.org/10.1172/jci.insight.151496

Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca6cf7f70e973bb64f7b6009b997c20
https://pubmed.ncbi.nlm.nih.gov/34375312

Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

Autor: Jens Meiler, Renae M. Ryan, Hassane S. Mchaourab, Andrea N Belovich, Amanda M. Duran, Manju A Kurian, Lei Shi, Yanqi Zhu, Alexandra C Schwartz, Josep Font, Heinrich J.G. Matthies, Aurelio Galli, Samuel J. Mabry, Kaitlyn Ledwitch, Angela M. Carter, Mary Hongying Cheng, Jenny I. Aguilar, Cristina Fenollar-Ferrer, Ivet Bahar

Publikováno v: eLife, Vol 10 (2021)
eLife

Parkinson disease (PD) is a progressive, neurodegenerative disorder affecting over 6.1 million people worldwide. Although the cause of PD remains unclear, studies of highly-penetrant mutations identified in early-onset familial parkinsonism have cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f749aab95f61ea8560389d4da0d68f24
https://pubmed.ncbi.nlm.nih.gov/34188226

Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

Autor: Stephen D. Carter, Wen Li, Sandra A. Murray, Deborah Fass, Jenny I. Aguilar, José María Carazo, Meir Aridor, Michael J. Calderon, Sruti Shiva, Leanna Eisenman, Zachary J. Farino, Elana S. Levy, Stephanie E. Siegmund, William J. Rice, Allen Volchuk, Jyotsna Pilli, Edward Yi, Robin Freyberg, Robert A. Grassucci, Christoph Wigge, Tamas Balla, Grant J. Jensen, Zachary Freyberg, Nili L. Greenberg, Roberto Melero, Kenneth N. Fish, Travis J Morgenstern, Cheri M. Hampton, Estela Area-Gomez, Maïté Courel, Joshua G. Pemberton, Sharon G. Wolf, Callen T. Wallace, William G. Mitchell, Joachim Frank, Emily W. George, Simon C. Watkins, Ngoc-Han Tran, Zachary P. Wills, Robert Langlois, Despoina Aslanoglou, Francesca Bartolini, Peter Walter, Jonathan A. Javitch

Publikováno v: Science advances, vol 6, iss 14
Science Advances
Digital.CSIC. Repositorio Institucional del CSIC
instname

The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo-electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6c12563619c7bb859ab52fcc61cc9e
https://escholarship.org/uc/item/54c9n3tb