Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Jenny H. Lee"'
Autor:
Wei Yen Chan, Jenny H. Lee, Ashleigh Stewart, Russell J. Diefenbach, Maria Gonzalez, Alexander M. Menzies, Christian Blank, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-9 (2024)
Abstract Background Neoadjuvant therapy improves recurrence-free survival (RFS) in resectable stage III cutaneous melanoma. However, accurately predicting individual recurrence risk remains a significant challenge. We investigated circulating tumour
Externí odkaz:
https://doaj.org/article/180a7ebfa6044158ab23c831a636c694
Autor:
Su Yin Lim, Yingxin Lin, Jenny H. Lee, Bernadette Pedersen, Ashleigh Stewart, Richard A. Scolyer, Georgina V. Long, Jean Y.H. Yang, Helen Rizos
Publikováno v:
EBioMedicine, Vol 107, Iss , Pp 105308- (2024)
Summary: Background: Melanoma is a heterogeneous cancer influenced by the plasticity of melanoma cells and their dynamic adaptations to microenvironmental cues. Melanoma cells transition between well-defined transcriptional cell states that impact tr
Externí odkaz:
https://doaj.org/article/0f6bc570850d4b089ffba99d3b6434f7
Autor:
Poorva Pradhan, Ke (Zoe) Wan, Li Chan, Tsu‐Hui (Hubert) Low, Raymond Wu, Jenny H. Lee, Carsten E. Palme, Jonathan R. Clark, Rebecca L. Venchiarutti
Publikováno v:
Cancer Medicine, Vol 13, Iss 16, Pp n/a-n/a (2024)
Abstract Background Perineural spread (PNS) is associated with a poor prognosis in cutaneous squamous cell carcinoma of the head and neck (cSCCHN). Hence, investigating facilitators and barriers of early diagnosis and treatment of PNS in cSCCHN may i
Externí odkaz:
https://doaj.org/article/568f0eea18264966ba9d46d90676bf4f
Autor:
Lauren Julia Brown, Victor Khou, Chris Brown, Marliese Alexander, Dasantha Jayamanne, Joe Wei, Lauren Gray, Wei Yen Chan, Samuel Smith, Susan Harden, Antony Mersiades, Lydia Warburton, Malinda Itchins, Jenny H. Lee, Nick Pavlakis, Stephen J. Clarke, Michael Boyer, Adnan Nagrial, Eric Hau, Ines Pires da Silva, Steven Kao, Benjamin Y. Kong
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionBrain metastases commonly occur in patients with non-small cell lung cancer (NSCLC). Standard first-line treatment for NSCLC, without an EGFR, ALK or ROS1 mutation, is either chemoimmunotherapy or anti-PD-1 monotherapy. Traditionally, pat
Externí odkaz:
https://doaj.org/article/091bc647cc054317a5b3754310f54a38
Autor:
Su Yin Lim, Elena Shklovskaya, Jenny H. Lee, Bernadette Pedersen, Ashleigh Stewart, Zizhen Ming, Mal Irvine, Brindha Shivalingam, Robyn P. M. Saw, Alexander M. Menzies, Matteo S. Carlino, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Immunotherapy resistance is common among melanoma patients. Here, the authors identify three resistance mechanism subtypes across tumor-derived cell lines and matched samples and highlight antigen presentation disruption as a key mediator of resistan
Externí odkaz:
https://doaj.org/article/3b0749adf7cc4ff997d621256e99d21e
Autor:
Russell J. Diefenbach, Jenny H. Lee, Ashleigh Stewart, Alexander M. Menzies, Matteo S. Carlino, Robyn P. M. Saw, Jonathan R. Stretch, Georgina V. Long, Richard A. Scolyer, Helen Rizos
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Detection of melanoma mutations using circulating tumor DNA (ctDNA) is a potential alternative to using genomic DNA from invasive tissue biopsies. To date, mutations in the GC-rich TERT promoter region, which is commonly mutated in melanoma, have bee
Externí odkaz:
https://doaj.org/article/d421e3d41d064555bbe005a85a89db8a
Autor:
Jenny H. Lee, Elena Shklovskaya, Su Yin Lim, Matteo S. Carlino, Alexander M. Menzies, Ashleigh Stewart, Bernadette Pedersen, Malama Irvine, Sara Alavi, Jean Y. H. Yang, Dario Strbenac, Robyn P. M. Saw, John F. Thompson, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Richard F. Kefford, Helen Rizos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
A significant proportion of patients develop innate or acquired resistance to immune checkpoint inhibitors. Here, the authors show that resistance to anti-PD-1 blockade is associated with TGF-beta driven major histocompatibility complex I (MHCI) down
Externí odkaz:
https://doaj.org/article/ab9ea89ca686469ba37cbf4ad9951d86
Autor:
Jorja Braden, Jenny H. Lee
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Immune checkpoint inhibitors (ICIs) have dramatically improved outcomes in melanoma. Common ICI toxicities have become familiar to clinicians; however, rare delayed toxicities remain challenging given the paucity of data with such presentations. We p
Externí odkaz:
https://doaj.org/article/a5ce585f24754eef83e1c00d47c6c95b
Autor:
Laveniya Satgunaseelan, Sean Porazinski, Dario Strbenac, Aji Istadi, Cali Willet, Tracy Chew, Rosemarie Sadsad, Carsten E. Palme, Jenny H. Lee, Michael Boyer, Jean Y. H. Yang, Jonathan R. Clark, Marina Pajic, Ruta Gupta
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
There is an increasing worldwide incidence of patients under 50 years of age presenting with oral squamous cell carcinoma (OSCC). The molecular mechanisms driving disease in this emerging cohort remain unclear, limiting impactful treatment options fo
Externí odkaz:
https://doaj.org/article/693a649c31a8476a9a20a57ba960f116
Autor:
Mehdi R. Pirozyan, Helen M. McGuire, Abdullah Al Emran, Hsin-Yi Tseng, Jessamy C. Tiffen, Jenny H. Lee, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, Barbara Fazekas de St Groth, Peter Hersey
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The development of changes in T cells, referred to as T cell exhaustion, has been suggested as a cause of primary or acquired resistance to immunotherapy by immune checkpoint blockade (ICB). A limited number of studies, largely performed on tumor inf
Externí odkaz:
https://doaj.org/article/6e68db4ea50f4cc7a1d2fb84e2013589