Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

Autor: Jennifer C. Regan, Yu-Xuan Lu, Enric Ureña, Ralf L. Meilenbrock, James H. Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge

Publikováno v: Regan, J C, Lu, Y X, Ureña, E, Meilenbrock, R L, Catterson, J H, Kißler, D, Fröhlich, J, Funk, E & Partridge, L 2022, ' Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin ', Nature Aging, vol. 2, no. 12, pp. 1145-1158 . https://doi.org/10.1038/s43587-022-00308-7
Nature Aging
Nature aging

Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin extends lifespan in females, but not in males. Female-specific, age-related g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097e8dde5d4949beb131caf9b20b0d04
https://doi.org/10.1038/s43587-022-00308-7

Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

Autor: Jonathan Paulitz, Luke S Tain, Linda Partridge, Sebastian Grönke, Andreas Beyer, Ralf Leslie Meilenbrock, Jenny Fröhlich, Manopriya Chokkalingam, Matthias Mann, Robert Sehlke, Nagarjuna Nagaraj, Thomas Leech, Ilian Atanassov

Publikováno v: Elife
eLife
eLife, Vol 10 (2021)

Reduced activity of the insulin/IGF signalling network increases health during ageing in multiple species. Diverse and tissue-specific mechanisms drive the health improvement. Here, we performed tissue-specific transcriptional and proteomic profiling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6f60c6507e24925d3e48c4d4770e8c
https://doi.org/10.7554/elife.67275

Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

Autor: Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F. Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C. Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge

Publikováno v: Nature aging
Juricic, P, Lu, Y X, Leech, T, Drews, L F, Paulitz, J, Lu, J, Nespital, T, Azami, S, Regan, J C, Funk, E, Fröhlich, J, Grönke, S & Partridge, L 2022, ' Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy ', Nature Aging, vol. 2, no. 9, pp. 824-836 . https://doi.org/10.1038/s43587-022-00278-w
Nature Aging

The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a bri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d8462bfe38804d4dd5a2825119afe0