Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Jenny E Gunton"'
Autor:
Sue Lynn Lau, Rebecca A Stokes, Beverly Ng, Kim Cheng, Roderick Clifton-Bligh, Jenny E Gunton
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0267573 (2022)
VDR expression has been found in many cell types involved in metabolism, including the beta-cells of the pancreatic islets. Activated vitamin D and its interactions with the vitamin D receptor (VDR) are implicated in glucose homeostasis. We investiga
Externí odkaz:
https://doaj.org/article/83b05def409748799dc639326d5a096a
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0223987 (2019)
Energy consuming, heat-producing beige adipocytes, located in classic white adipose tissue (WAT), hold promise for the treatment of obesity. Few reports have quantitatively assessed the contribution of browned 'WAT' to energy expenditure. There is a
Externí odkaz:
https://doaj.org/article/521ad9e60d5341cda47fb48bbc23b5a6
Autor:
Christopher Scott, Rebecca Stokes, Kuan Minn Cha, Andrew Clouston, Mohammed Eslam, Mayda Metwally, Michael M Swarbrick, Jacob George, Jenny E Gunton
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225332 (2019)
BACKGROUND AND AIM:Non-alcoholic steatohepatitis (NASH) is predicted to become the most common cause of cirrhosis and liver failure. Risk factors include obesity, insulin resistance and diabetes. Macrophages and other myeloid cells play crucial roles
Externí odkaz:
https://doaj.org/article/f9a3743b22274f67b607c94eed3743ca
Autor:
Christopher H Scott, Kuan-Minn Cha, Jason Ngai, Changtao Jiang, Kim Cheng, Rebecca A Stokes, Kenneth W K Ho, Jacob George, Frank J Gonzalez, Jenny E Gunton
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0186543 (2017)
Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) and its partners hypoxia-inducible factors (HIF)-1α and HIF-2α are candidate factors for the well-known link between the liver, metabolic dysfunction and elevation in circulating lipids and gluc
Externí odkaz:
https://doaj.org/article/b07a777ca221483bb4f3576a2575da81
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Smoking may increase the risk of diabetic foot disease and ulceration. It does so by impairing glycaemic control and promoting the formation of advanced glycated end-products. Additionally, smoking is known to delay surgical wound healing an
Externí odkaz:
https://doaj.org/article/b23beb85b7dc44f8a29ba46ca8734ba9
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121650 (2015)
Recent studies have shown that increased expression of liver hypoxia inducible factor 2-α (HIF-2α) leads to liver inflammation and a pro-fibrotic gene expression signature. Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) is required for HIF-2
Externí odkaz:
https://doaj.org/article/f155d04de6e6452ba4ffbbc5b98ba07f
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98435 (2014)
BACKGROUND: Replacing β-cells by islet-transplantation can cure type 1 diabetes, but up to 70% of β-cells die within 10 days of transplantation. ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) regulates β-cell function, and potentially survi
Externí odkaz:
https://doaj.org/article/946a6a46d2fd46569ec7e71ec615ad8e
Autor:
Sue Mei Lau, Kuan Minn Cha, Ayesha Karunatillake, Rebecca A Stokes, Kim Cheng, Mark McLean, N W Cheung, Frank J Gonzalez, Jenny E Gunton
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77419 (2013)
AIMS:Insulin secretion increases in normal pregnancy to meet increasing demands. Inability to increase beta-cell function results in gestational diabetes mellitus (GDM). We have previously shown that the expression of the transcription factor ARNT (A
Externí odkaz:
https://doaj.org/article/5602d6b17fe1470283f86502df3d9b37
Autor:
Kim Cheng, Viviane Delghingaro-Augusto, Christopher J Nolan, Nigel Turner, Nicole Hallahan, Sofianos Andrikopoulos, Jenny E Gunton
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40868 (2012)
Type 2 diabetes is a metabolic disorder characterized by the inability of beta-cells to secrete enough insulin to maintain glucose homeostasis. MIN6 cells secrete insulin in response to glucose and other secretagogues, but high passage (HP) MIN6 cell
Externí odkaz:
https://doaj.org/article/eb70c21f5557456a87223dfd6015e7e6
Autor:
Jenny E Gunton, Mary Sisavanh, Rebecca A Stokes, Jon Satin, Leslie S Satin, Min Zhang, Sue M Liu, Weikang Cai, Kim Cheng, Gregory J Cooney, D Ross Laybutt, Trina So, Juan-Carlos Molero, Shane T Grey, Douglas A Andres, Michael S Rolph, Charles R Mackay
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39462 (2012)
AIMS AND HYPOTHESIS:Glucose-stimulated insulin secretion from beta-cells is a tightly regulated process that requires calcium flux to trigger exocytosis of insulin-containing vesicles. Regulation of calcium handling in beta-cells remains incompletely
Externí odkaz:
https://doaj.org/article/7e888d5d96f54d44a11c04ca0d7a1069