Zobrazeno 1 - 10 of 61 pro vyhledávání: '"Jenny D. Chiu"'
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Akademický článek
High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets.
Autor: Orison O Woolcott, Joyce M Richey, Morvarid Kabir, Robert H Chow, Malini S Iyer, Erlinda L Kirkman, Darko Stefanovski, Maya Lottati, Stella P Kim, L Nicole Harrison, Viorica Ionut, Dan Zheng, Isabel R Hsu, Karyn J Catalano, Jenny D Chiu, Heather Bradshaw, Qiang Wu, Cathryn M Kolka, Richard N Bergman
Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123558 (2015)
BACKGROUND:Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia. OBJECTIVE:To determine whet
Externí odkaz: https://doaj.org/article/a9550449b61140ec87d3e78492fae4f0
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4
CB1 antagonism restores hepatic insulin sensitivity without normalization of adiposity in diet-induced obese dogs
Autor: Dan Zheng, Richard N. Bergman, Orison O. Woolcott, Viorica Ionut, Maya Lottati, Darko Stefanoski, Isabel R. Hsu, Morvarid Kabir, Stella P. Kim, Karyn J. Catalano, L. Nicole Harrison, Cathryn M. Kolka, Joyce M. Richey, Jenny D. Chiu
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 302:E1261-E1268
The endocannabinoid system is highly implicated in the development of insulin resistance associated with obesity. It has been shown that antagonism of the CB1 receptor improves insulin sensitivity (SI). However, it is unknown whether this improvement
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f8514153d65178253b4096ca3a55c5
https://doi.org/10.1152/ajpendo.00496.2011
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5
Diet-Induced Obesity Prevents Interstitial Dispersion of Insulin in Skeletal Muscle
Autor: L. Nicole Harrison, Erlinda L. Kirkman, Richard N. Bergman, Cathryn M. Kolka, Jenny D. Chiu, Maya Lottati
Publikováno v: Diabetes
OBJECTIVE Obesity causes insulin resistance, which has been interpreted as reduced downstream insulin signaling. However, changes in access of insulin to sensitive tissues such as skeletal muscle may also play a role. Insulin injected directly into s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b92134c8f42fc3177f18326cdd62630
https://doi.org/10.2337/db09-0839
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6
Experimental Hyperlipidemia Dramatically Reduces Access of Insulin to Canine Skeletal Muscle
Autor: Erlinda L. Kirkman, Cathryn M. Kolka, Lisa N. Harrison, Edward Zuniga, Richard N. Bergman, Joyce M. Richey, Jenny D. Chiu
Publikováno v: Obesity. 17:1486-1492
A complex sequence of steps is required for insulin to cause glucose uptake. Impairment of any one of these steps can contribute to insulin resistance. We observed the effect of insulin resistance induced by hyperlipidemia on the dynamics of insulin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086a1683e514556f408626126a6767da
https://doi.org/10.1038/oby.2009.165
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7
Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs
Autor: L. Nicole Harrison, Morvarid Kabir, Darko Stefanovski, Richard N. Bergman, Orison O. Woolcott, Cathryn M. Kolka, Dan Zheng, Viorica Ionut, Vahe Mooradian, Isabel R. Hsu, Stella P. Kim, Maya Lottati, Joyce M. Richey, Karyn J. Catalano, Jenny D. Chiu
Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 296:E1311-E1318
We investigated whether rimonabant, a type 1 cannabinoid receptor antagonist, reduces visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in dogs maintained on a hypercaloric high-fat diet (HHFD). To determine whether energy expenditu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621036c4e09dba952a8e294432e1d5f8
https://doi.org/10.1152/ajpendo.90972.2008
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8
Direct Administration of Insulin Into Skeletal Muscle Reveals That the Transport of Insulin Across the Capillary Endothelium Limits the Time Course of Insulin to Activate Glucose Disposal
Autor: Erlinda L. Kirkman, Joyce M. Richey, Edward Zuniga, Cathryn M. Kolka, L. Nicole Harrison, Martin Ellmerer, Richard N. Bergman, Jenny D. Chiu
Publikováno v: Diabetes. 57:828-835
OBJECTIVE—Intravenous insulin infusion rapidly increases plasma insulin, yet glucose disposal occurs at a much slower rate. This delay in insulin's action may be related to the protracted time for insulin to traverse the capillary endothelium. An i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468f68f9823c89ce91ad09365e1674f9
https://doi.org/10.2337/db07-1444
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9
Abdominal Obesity: Role in the Pathophysiology of Metabolic Disease and Cardiovascular Risk
Autor: Stella P. Kim, Richard N. Bergman, Marilyn Ader, Jenny D. Chiu, Joyce M. Richey, Isabel R. Hsu, Morvarid Kabir, Karyn J. Catalano
Publikováno v: The American Journal of Medicine. 120:S3-S8
Visceral adiposity has been identified as an independent risk factor for cardiovascular disease and the so-called metabolic syndrome. The canine obesity model closely recapitulates the correlation between human visceral adiposity and insulin resistan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbeede36d8a19e2feec0ebf0cf58c8ab
https://doi.org/10.1016/j.amjmed.2006.11.012
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