Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jenny C. Schafer"'
Autor:
Ly Pham, Padmini Komalavilas, Alex M. Eddie, Timothy E. Thayer, Dalton L. Greenwood, Ken H. Liu, Jaclyn Weinberg, Andrew Patterson, Joshua P. Fessel, Kelli L. Boyd, Jenny C. Schafer, Jamie L. Kuck, Aaron C. Shaver, David K. Flaherty, Brittany K. Matlock, Christiaan D. M. Wijers, C. Henrique Serezani, Dean P. Jones, Evan L. Brittain, Jeffrey C. Rathmell, Michael J. Noto
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Cpt1a-dependent fatty acid beta-oxidation is found to regulate neutrophil trafficking to the site of infection in a mouse model of pneumonia and is found to play a role in pneumonia susceptibility in humans.
Externí odkaz:
https://doaj.org/article/d76a7386c54d4c2f854b839fc40b5550
Autor:
Jenny C. Schafer, Lynne A. Lapierre, Rebecca E. McRae, Elizabeth H. Manning, James R. Goldenring
Publikováno v:
Experimental Cell Research. 340:259-273
The Rab11 family of small GTPases, along with the Rab11-family interacting proteins (Rab11-FIPs), are critical regulators of intracellular vesicle trafficking and recycling. We have identified a point mutation of Threonine-197 site to an Alanine in R
Autor:
Nicholas W. Baetz, Joseph T. Roland, Rebecca E. McRae, James R. Goldenring, Jenny C. Schafer, Lynne A. Lapierre
Publikováno v:
Traffic. 15:292-308
A tripartite association of Rab11a with both Rab11-FIP2 and MYO5B regulates recycling endosome trafficking. We sought to define the intermolecular interactions required between Rab11-FIP2 and MYO5B. Using a random mutagenesis strategy, we identified
Publikováno v:
The Journal of Biological Chemistry
Dual-specific A-kinase-anchoring protein 2 (D-AKAP2/AKAP10), which interacts at its carboxyl terminus with protein kinase A and PDZ domain proteins, contains two tandem regulator of G-protein signaling (RGS) domains for which the binding partners hav
Autor:
Bradley K. Yoder, Corey L. Williams, Edward J. Michaud, Jenny C. Schafer, Marlene E. Winkelbauer
Publikováno v:
Molecular Biology of the Cell. 19:2154-2168
Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and Joubert syndrome (JBTS) are a group of heterogeneous cystic kidney disorders with partially overlapping loci. Many of the proteins associated with these diseases interact and localize to cili
Autor:
Bradley K. Yoder, Yasumi Ohshima, Michel R. Leroux, Makato Koga, Jenny C. Schafer, Chunmei Li, Oliver E. Blacque, Jonathan M. Scholey, Takashi Murayama, Guangshuo Ou
Publikováno v:
Molecular Biology of the Cell. 18:1554-1569
Sensory cilium biogenesis within Caenorhabditis elegans neurons depends on the kinesin-2–dependent intraflagellar transport (IFT) of ciliary precursors associated with IFT particles to the axoneme tip. Here we analyzed the molecular organization of
Autor:
Courtney J. Haycraft, Bradley K. Yoder, Peter Swoboda, Marlene E. Winkelbauer, Jenny C. Schafer
Publikováno v:
Journal of Cell Science. 118:5575-5587
Nephronophthisis (NPH) is a cystic kidney disorder that causes end-stage renal failure in children. Five nephrocystin (nephrocystin-1 to nephrocystin-5) genes, whose function is disrupted in NPH patients, have been identified and data indicate they f
Publikováno v:
Experimental Cell Research. 284:249-261
Cilia are present on cells of many eukaryotic organisms and recent data in the mouse suggest that ciliary defects can cause severe developmental abnormalities and disease. Studies across eukaryotic systems indicate that cilia are constructed and main
Autor:
Jenny C, Schafer, Nicholas W, Baetz, Lynne A, Lapierre, Rebecca E, McRae, Joseph T, Roland, James R, Goldenring
Publikováno v:
Traffic (Copenhagen, Denmark). 15(3)
A tripartite association of Rab11a with both Rab11-FIP2 and MYO5B regulates recycling endosome trafficking. We sought to define the intermolecular interactions required between Rab11-FIP2 with MYO5B. Using a random mutagenesis strategy, we identified
Publikováno v:
The FASEB Journal. 23