Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jenny C. Link"'
Autor:
Peixiang Zhang, Joseph J. Munier, Carrie B. Wiese, Laurent Vergnes, Jenny C. Link, Fahim Abbasi, Emilio Ronquillo, Katherine Scheker, Antonio Muñoz, Yu-Lin Kuang, Elizabeth Theusch, Meng Lu, Gabriela Sanchez, Akinyemi Oni-Orisan, Carlos Iribarren, Michael J. McPhaul, Daniel K. Nomura, Joshua W. Knowles, Ronald M. Krauss, Marisa W. Medina, Karen Reue
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glu
Externí odkaz:
https://doaj.org/article/332ede39ee3b4894add02807a1a4ed96
Autor:
Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjørk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Büning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Tröder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepat
Externí odkaz:
https://doaj.org/article/4ccddec6eb3c494894508ff7177b7683
Autor:
Chieh Chen, Brett Lomenick, Min Chai, Wilson Huang, Jessie Chu, Laurent Vergnes, Reid O’Brien Johnson, Ajay A. Vashisht, Randall M. Chin, Melissa M. Dix, Gabriel Simon, Xudong Fu, Jenny C. Link, Heejun Hwang, Xiang Yin, Stéphanie C. de Barros, Daniel Braas, Nahn Hee Diane Kim, Yibin Wang, Steven M. Dubinett, Michael A. Teitell, Oliver Fiehn, Meisheng Jiang, Benjamin F. Cravatt, James A. Wohlschlegel, Joseph A. Loo, Karen Reue, Jing Huang
Aging is a complex process that is directly related to human health and disease. The extraordinary finding that aging is malleable, as shown in model organisms whose life and health spans are extended by specific gene mutations or dietary or pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155c4778bd35323664c7ac99f97892f9
https://doi.org/10.1101/2022.10.10.511641
https://doi.org/10.1101/2022.10.10.511641
Autor:
Peixiang Zhang, Joseph J. Munier, Laurent Vergnes, Carrie B. Wiese, Jenny C. Link, Fahim Abbasi, Emilio Ronquillo, Antonio Muñoz, Yu-Lin Kuang, Meng Liu, Gabriela Sanchez, Akinyemi Oni-Orisan, Carlos Iribarren, Michael J. McPhaul, Daniel K. Nomura, Joshua W. Knowles, Ronald M. Krauss, Marisa W. Medina, Karen Reue
SummaryStatin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. We determined that female mice a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b80051dd53828fdb68394f7c8c3a66f3
https://doi.org/10.1101/2022.08.29.505759
https://doi.org/10.1101/2022.08.29.505759
Autor:
Yii-Der Ida Chen, Matthew A. Allison, Jenny C. Link, Jie Yao, Emilio Ronquillo, Matteo Pellegrini, Arthur P. Arnold, Jerome I. Rotter, Karen Reue, Laurent Vergnes, Xuqi Chen, Rozeta Avetisyan, Carrie B. Wiese, Xiuqing Guo, Julia S. El-Sayed Moustafa, Shigeki Iwase, Feiyang Ma, Kerrin S. Small
Publikováno v:
J Clin Invest
Males and females differ in body composition and fat distribution. Using a mouse model that segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we showed that XX chromosome complement in combination with a high-fat diet led
Autor:
Hande Topel, Hildegard Büning, Peter A. Edwards, Peter Frommolt, Jan-Wilhelm Kornfeld, Bjørk Ditlev Larsen, Igor Ulitsky, Dario F. De Jesus, Ines Dhaouadi, Elena Schmidt, Robin Schwarzer, Rohit N. Kulkarni, Richard G. Lee, Ling Yang, Haiming Cao, Nils R. Hansmeier, Christoph A. Kiefer, Thomas Q. de Aguiar Vallim, Sajjad Khani, Branko Zevnik, Rute Loureiro, Christoph Dieterich, Jenny C. Link, Ludger Scheja, Matteo Oliverio, Motoharu Awazawa, Marta Pradas-Juni, Eduardo Fernandez-Rebollo, Masayuki Yamamoto, Simon E. Tröder, Nicola Meola, Paul Klemm, Joerg Heeren, Uwe Knippschild, Markus Heine
Publikováno v:
Pradas-Juni, M, Hansmeier, N R, Link, J C, Schmidt, E, Larsen, B D, Klemm, P, Meola, N, Topel, H, Loureiro, R, Dhaouadi, I, Kiefer, C A, Schwarzer, R, Khani, S, Oliverio, M, Awazawa, M, Frommolt, P, Heeren, J, Scheja, L, Heine, M, Dieterich, C, Büning, H, Yang, L, Cao, H, Jesus, D F D, Kulkarni, R N, Zevnik, B, Tröder, S E, Knippschild, U, Edwards, P A, Lee, R G, Yamamoto, M, Ulitsky, I, Fernandez-Rebollo, E, Vallim, T Q D A & Kornfeld, J-W 2020, ' A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism ', Nature Communications, vol. 11, no. 1, 644 . https://doi.org/10.1038/s41467-020-14323-y
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Obesity and type 2 diabetes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, are repressed d
Autor:
Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Jenny C. Link, Vivian Iloabuchi, Tyler Laws
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Karen Reue, Jenny C. Link
Publikováno v:
Annual review of nutrition., vol 37, iss 1
Men and women exhibit significant differences in obesity, cardiovascular disease, and diabetes. To provide better diagnosis and treatment for both sexes, it is important to identify factors that underlie the observed sex differences. Traditionally, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3724a81412c317ca90ace05ec36b25ac
https://escholarship.org/uc/item/5510j52r
https://escholarship.org/uc/item/5510j52r
Autor:
Yehudit Hasin-Brumshtein, Rita M. Cantor, Aldons J. Lusis, Karen Reue, Arthur P. Arnold, Xuqi Chen, Jenny C. Link
Publikováno v:
BMC genomics, vol 18, iss 1
BMC Genomics
BMC Genomics
Background MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5d53c1de5dfd78d9112f7f92d50900
https://escholarship.org/uc/item/2kx045zn
https://escholarship.org/uc/item/2kx045zn
Publikováno v:
Developmental Dynamics. 242:371-379
Background: The classic model of sex determination in mammals states that the sex of the individual is determined by the type of gonad that develops, which in turn determines the gonadal hormonal milieu that creates sex differences outside of the gon