Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jenny Björkqvist"'
Autor:
Markus M. Nöthen, Urs Lewandrowski, Con Panousis, Hal Braley, Coen Maas, Christian Drouet, Jenny Björkqvist, Albert Sickmann, Marc W. Nolte, Antonio Di Gennaro, Chris Oschatz, Thomas Renné, Kai Schönig, Steven de Maat
Publikováno v:
Journal of Clinical Investigation. 125:3132-3146
Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated with point mutations in the gene encoding the plasma protease factor XII (FXII). Here, we demonstrate that HAEIII-associated mutant FXII, derived either
Publikováno v:
Thrombosis and Haemostasis. 112:868-875
SummaryCombinations of proinflammatory and procoagulant reactions are the unifying principle for a variety of disorders affecting the cardiovascular system. Factor XII (FXII, Hageman factor) is a plasma protease that initiates the contact system. The
Publikováno v:
Thrombosis and Haemostasis. 109:368-374
SummaryEdema is tissue swelling and is a common symptom in a variety of diseases. Edema form due to accumulation of fluids, either through reduced drainage or increased vascular permeability. There are multiple vascular signalling pathways that regul
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 25(8)
In the activated partial thromboplastin time (APTT) assay, a variety of nonphysiological reagents is used to induce contact activation. The sensitivity of the APTT response for different thrombin inhibitors has previously been found to be dependent o
Autor:
Con Panousis, Anne Jämsä, Ingo Pragst, Patricia Hedenqvist, Marion Fries, Jenny Björkqvist, Matthew P. Hardy, Michael J. Wilson, Michael Broomé, Andrew D. Nash, Marc W. Nolte, Magnus Larsson, Katrin F. Nickel, Stefan Schmidbauer, Thomas Renné, Gerhard Dickneite, Veronika Rayzman
Publikováno v:
Science Translational Medicine. 6
Currently used anticoagulants prevent thrombosis but increase bleeding. We show an anticoagulation therapy without bleeding risk based on a plasma protease factor XII function-neutralizing antibody. We screened for antibodies against activated factor
Autor:
Antonio Di Gennaro, Ulrich Hassiepen, Katrin F. Nickel, Tobias A. Fuchs, Olga Luengo, Andy T. Long, Evi X. Stavrou, Thomas Renné, Thorsten Krieger, Ellinor Kenne, Hartmut Schlüter, Keith R. McCrae, Stefanie Flohr, Riccardo Senter, Mar Guilarte, Moisés Labrador, Jenny Björkqvist, Lynn M. Butler, Anne Jämsä, Frederic Cumin, Anna Sala-Cunill, Victoria Cardona, Linda Labberton, Parvin Kumar, Coen Maas
Publikováno v:
Journal of Allergy and Clinical Immunology, 135(4), 1031. Mosby Inc.
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Background Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell–derived mediators into the circulation. Objectives and Methods We report here that a plasma protease cascade, the factor XII
Autor:
Thomas Renné, Gerard Pasterkamp, Arnold C. Koekman, Marco Cicardi, Jenny Björkqvist, Steven de Maat, Philip G. de Groot, Chiara Suffritti, Sanne van Dooremalen, Coen Maas, Willem Nagtegaal, Chantal P. Wiesenekker
Publikováno v:
Journal of Allergy and Clinical Immunology, 138(5), 1414. Mosby Inc.
Background Patients with angioedema experience unpredictable attacks of tissue swelling in which bradykinin is implicated. Several distinct mutations in Factor XII (FXII) are associated with hereditary angioedema (HAE) in the presence of normal C1 es
Publikováno v:
Thrombosis and haemostasis. 110(3)
SummaryPlasma prekallikrein is the liver-derived precursor of the trypsin-like serine protease plasma kallikrein (PK) and circulates in plasma bound to high molecular weight kininogen. The zymogen is converted to PK by activated factor XII. PK drives
Publikováno v:
Biological chemistry. 394(9)
Contact to polyanions induces autoactivation of the serine protease factor XII that triggers the kallikrei-kinin system. Recent studies indicate that polysaccharide-induced autoactivation of factor XII has a role in allergy-related vascular leakage,
Autor:
Thomas Renné, Anna Sala-Cunill, Katrin F. Nickel, Moisés Labrador, V. Cardona, Mar Guilarte, Olga Luengo, Jenny Björkqvist
Publikováno v:
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