Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jenny A. Orchard"'
Autor:
Rachel E. Ibbotson, R V Seear, Anne Gardiner, Jenny A. Orchard, Nicholas C.P. Cross, Andrew Chase, L Y Zhang, David Oscier
Publikováno v:
Leukemia. 17:2097-2100
The P2X7 receptor, a plasma membrane ATP-gated ion channel that plays a role in lymphocyte apoptosis, has been suggested as an important contributory factor to the pathogenesis of chronic lymphocytic leukaemia (CLL). The P2X7 gene resides on chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f499e0f70bd836707fe4fbb6458ee3f0
https://doi.org/10.1038/sj.leu.2403125
https://doi.org/10.1038/sj.leu.2403125
Autor:
Louis M. Staudt, George E. Wright, Adrian Wiestner, Rachel E. Ibbotson, Diane C. Arthur, Todd S. Barry, R. Eric Davis, Mark Raffeld, Wyndham H. Wilson, Jenny A. Orchard, Terry J. Hamblin, Hong Zhao, Gerald E. Marti, Zadie Davis, David Oscier, Andreas Rosenwald, Sarah E. Henrickson, Maryalice Stetler-Stevenson
Publikováno v:
Blood. 101:4944-4951
The presence or absence of somatic mutations in the expressed immunoglobulin heavy chain variable regions (IgVH) of chronic lymphocytic leukemia (CLL) cells provides prognostic information. Patients whose leukemic cells express unmutated IgVH regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bec3a38d82698cbdef4af850114b51
https://doi.org/10.1182/blood-2002-10-3306
https://doi.org/10.1182/blood-2002-10-3306
Autor:
Jenny A. Orchard, Terry J. Hamblin, Sarah Mould, Rachel E. Ibbotson, Zadie Davis, Peter Thomas, R. Chapman, David Oscier, Sharron Glide, Anne Gardiner, Martin Corcoran, J. Adrian Copplestone
Publikováno v:
Blood. 100:1177-1184
This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology, CD38 expression, and IGVHgene status in 205 patients with chronic lymphocytic leukemia (B-CL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f1801e6c12ee3114a386d70ce8f826
https://doi.org/10.1182/blood.v100.4.1177.h81602001177_1177_1184
https://doi.org/10.1182/blood.v100.4.1177.h81602001177_1177_1184
Autor:
Rachel E. Ibbotson, Terry J. Hamblin, Jenny A. Orchard, Peter Thomas, Freda K. Stevenson, Zadie Davis, David Oscier
Publikováno v:
Blood. 99:1023-1029
Although the presence or absence of somatic mutations in the immunoglobulin variable region (IgVH) genes in chronic lymphocytic leukemia (B-CLL) identifies subtypes with very different prognoses, the assay is technically complex and unavailable to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ebc74f0b3c774393256d54e0b7a07db
https://doi.org/10.1182/blood.v99.3.1023
https://doi.org/10.1182/blood.v99.3.1023
Autor:
Sarah Mould, Jenny A. Orchard, Stephen W. Scherer, Rachel E. Ibbotson, Martin Corcoran, Lap-Chee Tsui, Platt C, Andrew P. Boright, R. Chapman, David Oscier
Publikováno v:
Oncogene. 18:6271-6277
The increased or inappropriate expression of genes with oncogenic properties through specific chromosome translocations is an important event in the pathogenesis of B-cell lymphoproliferative diseases. Recent studies have found deletions or transloca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285ff4987cce61222fe37d708ba38079
https://doi.org/10.1038/sj.onc.1203033
https://doi.org/10.1038/sj.onc.1203033
Autor:
VA Craig, David J. Curtis, Jenny A. Orchard, H. Myint, J. A. Copplestone, Archie G. Prentice, M. D. Hamon, David Oscier, Terry J. Hamblin
Publikováno v:
British Journal of Haematology. 91:341-344
We have treated 52 patients with chronic lymphocytic leukaemia (CLL) with fludarabine; 12 developed severe autoimmune haemolysis. Only three had a previous history of haemolytic anaemia. Six out of eight patients retreated with fludarabine after cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d840fc4f32ddd5479c5024936b01ddc
https://doi.org/10.1111/j.1365-2141.1995.tb05300.x
https://doi.org/10.1111/j.1365-2141.1995.tb05300.x
Autor:
Zadie Davis, Jenny A. Orchard, David Oscier, Terry J. Hamblin, Anne Gardiner, Freda K. Stevenson
Publikováno v:
Blood. 95:2455-2457
To the editor: Immunoglobulin V genes and CD38 expression in CLL The finding that the mutational status of immunoglobulin (Ig) V genes correlates with identifiable disease subsets of chronic lymphocytic leukemia (CLL) and is of prognostic importance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9490be86e86ed019301820b2f499d7b9
https://doi.org/10.1182/blood.v95.7.2455.007a43c_2455_2457
https://doi.org/10.1182/blood.v95.7.2455.007a43c_2455_2457
Autor:
Andrew G. Bosanquet, A. G. Smith, Jenny A. Orchard, S. A. Johnson, S. J. Povey, J. A. Copplestone, David Oscier
Publikováno v:
British Journal of Haematology. 106:474-476
The ability to identify non-responders to cytotoxic chemotherapy has significant clinical and economic benefits. Differential staining cytotoxicity (DiSC) assays were performed in 34 previously treated patients with chronic lymphocytic leukaemia prio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006a423658e9f6f22b0b5897737a0fa0
https://doi.org/10.1046/j.1365-2141.1999.01581.x
https://doi.org/10.1046/j.1365-2141.1999.01581.x
Autor:
Rachel E. Ibbotson, Jenny A. Orchard, Zadie Davis, David Oscier, A. E. Parker, Oliver Giles Best
Publikováno v:
Cytometry. Part B, Clinical cytometry. 70(4)
Background: The clinical course of chronic lymphocytic leukaemia (CLL) is variable. ZAP-70 expression is believed to provide prognostic information. The flow cytometric detection of ZAP-70 is difficult because it is an intracellular antigen with weak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffa37491415356a9e3edb7d899a4c18
https://pubmed.ncbi.nlm.nih.gov/16906573
https://pubmed.ncbi.nlm.nih.gov/16906573
Publikováno v:
Leukemialymphoma. 46(12)
ZAP-70 has emerged as a protein of potential prognostic importance in chronic lymphocytic leukemia (CLL) following gene expression profiling which compared the 2 well established prognostic sub-sets, those with unmutated and mutated IgVH genes. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4106ba8b15ba461ad2ad00ad75f704d
https://pubmed.ncbi.nlm.nih.gov/16263570
https://pubmed.ncbi.nlm.nih.gov/16263570