Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jenny A Klein"'
Autor:
Martin H Berryer, Gizem Rizki, Anna Nathanson, Jenny A Klein, Darina Trendafilova, Sara G Susco, Daisy Lam, Angelica Messana, Kristina M Holton, Kyle W Karhohs, Beth A Cimini, Kathleen Pfaff, Anne E Carpenter, Lee L Rubin, Lindy E Barrett
Publikováno v:
eLife, Vol 12 (2023)
Resolving fundamental molecular and functional processes underlying human synaptic development is crucial for understanding normal brain function as well as dysfunction in disease. Based upon increasing evidence of species-divergent features of brain
Externí odkaz:
https://doaj.org/article/1b1cfc36dbc340f8813d1636391740e6
Autor:
Saptaparni Bandyopadhyay, Joseph Douglass, Sebastian Kapell, Nazimuddin Khan, Fabiana Feitosa-Suntheimer, Jenny A Klein, Jasmine Temple, Jayce Brown-Culbertson, Alexander H Tavares, Mohsan Saeed, Nelson C Lau
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
AbstractKnock-in of large transgenes by Cas9-mediated homology-directed repair (HDR) is an extremely inefficient process. Although the use of single-stranded oligonucleotides (ssODN) as an HDR donor has improved the integration of smaller transgenes,
Externí odkaz:
https://doaj.org/article/ffeb213c30324a049291034addffb04b
Autor:
Zhen Li, Jenny A. Klein, Sanjeev Rampam, Ronni Kurzion, Natalie Baker Campbell, Yesha Patel, Tarik F. Haydar, Ella Zeldich
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The intellectual disability (ID) in Down syndrome (DS) is thought to result from a variety of developmental deficits such as alterations in neural progenitor division, neurogenesis, gliogenesis, cortical architecture, and reduced cortical volume. How
Externí odkaz:
https://doaj.org/article/67f9da21a494489798d3e6a36b394920
Autor:
Jenny A. Klein, Tarik F. Haydar
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Great strides have been made over the past 30 years in understanding the neurodevelopmental changes underlying the intellectual disability (ID) in Down syndrome (DS). Detailed studies of human tissue coupled with findings from rodent and induced plur
Externí odkaz:
https://doaj.org/article/8d38a6523bb3402bb7279b70c1d289b7
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
Mouse models of Down syndrome (DS) have been invaluable tools for advancing knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it recapitulat
Externí odkaz:
https://doaj.org/article/61f4148cd77046ca8aeed53a7a8176bd
Autor:
Martin H Berryer, Gizem Rizki, Anna Nathanson, Jenny A Klein, Darina Trendafilova, Sara G Susco, Daisy Lam, Angelica Messana, Kristina M Holton, Kyle W Karhohs, Beth A Cimini, Kathleen Pfaff, Anne E Carpenter, Lee L Rubin, Lindy E Barrett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008f9d606fa95833af908250dbc7cb32
https://doi.org/10.7554/elife.80168.sa2
https://doi.org/10.7554/elife.80168.sa2
Autor:
Martin H. Berryer, Matthew Tegtmeyer, Loïc Binan, Vera Valakh, Anna Nathanson, Darina Trendafilova, Ethan Crouse, Jenny A. Klein, Daniel Meyer, Olli Pietiläinen, Francesca Rapino, Samouil L. Farhi, Lee L. Rubin, Steven A. McCarroll, Ralda Nehme, Lindy E. Barrett
Astrocytes play essential roles in normal brain function, with dysfunction implicated in diverse developmental and degenerative disease processes. Emerging evidence of profound species divergent features of astrocytes coupled with the relative inacce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c7aae7bbb38b5cdbd606525b5d5512
https://doi.org/10.1101/2022.09.07.507028
https://doi.org/10.1101/2022.09.07.507028
Autor:
Jenny A. Klein, Zhen Li, Sanjeev Rampam, Jack Cardini, Amara Ayoub, Patricia Shaw, Angela L. Rachubinski, Joaquin M. Espinosa, Ella Zeldich, Tarik F. Haydar
Publikováno v:
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience, Vol 15 (2022)
Frontiers in Cellular Neuroscience, Vol 15 (2022)
The intellectual disability found in people with Down syndrome is associated with numerous changes in early brain development, including the proliferation and differentiation of neural progenitor cells (NPCs) and the formation and maintenance of myel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e1e167eaf3d681b4fc99f999f192a1
https://pubmed.ncbi.nlm.nih.gov/35058753
https://pubmed.ncbi.nlm.nih.gov/35058753
Autor:
Jasmine Temple, Joseph Douglass, Sebastian Kapell, Mohsan Saeed, Nelson C. Lau, Jenny A. Klein, Jayce Brown-Culbertson, Saptaparni Bandyopadhyay, Nazimuddin Khan, Alexander H Tavares, Fabiana Feitosa-Suntheimer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 8 (2021)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
Knock-in of large transgenes by Cas9-mediated homology-directed repair (HDR) is an extremely inefficient process. Although the use of single-stranded oligonucleotides (ssODN) as an HDR donor has improved the integration of smaller transgenes, they do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59861f17791cd5533ce301533d51705
https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab169
https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkab169
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 9 (2020)
Mouse models of Down syndrome (DS) have been invaluable tools for advancing knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it recapitulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec1e9b287e11d952b46a4e8e1cff562
https://doi.org/10.1242/dmm.046243
https://doi.org/10.1242/dmm.046243