Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jenny M. Pedersen"'
Autor:
Jenny M Pedersen, Yoo-Sik Shim, Vaibhav Hans, Martin Blake Phillips, Jeffrey M. Macdonald, Glenn Walker, Melvin E. Andersen, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 4 (2016)
Accurate prediction of metabolism is a significant outstanding challenge in toxicology. The best predictions are based on experimental data from in vitro systems using primary hepatocytes. The predictivity of the primary hepatocyte-based culture syst
Externí odkaz:
https://doaj.org/article/88ed7d6f48f94a27a7855aeae14a7820
Autor:
André Mateus, Anna Vildhede, Jozef Urdzik, Niklas Handin, Inken Flörkemeier, Per Artursson, Andrea Treyer, Jenny M. Pedersen, Christine Wegler, Edward L. LeCluyse, Magnus Ölander
Human hepatocytes show marked differences in cell size, gene expression, and function throughout the liver lobules, an arrangement termed liver zonation. However, it is not clear if these zonal size differences, and the associated phenotypic differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723ce6f18f99bb33ef3269c81c76dd21
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382404
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-382404
Autor:
Joseph W. Polli, Jonathan Maher, Kunal S Taskar, A. David Rodrigues, Christoph Funk, Michael J. Hafey, Robert W. Yucha, Kim L. R. Brouwer, Y. Anne Pak, Paul B. Watkins, David Dai, Jenny M. Pedersen, David L. Bourdet, Kyunghee Yang, Christina Battista, J. Gerry Kenna, Yurong Lai, Kenneth R. Brouwer
Publikováno v:
Clinical Pharmacology and Therapeutics
Bile salt export pump (BSEP) inhibition has emerged as an important mechanism that may contribute to the initiation of human drug-induced liver injury (DILI). Proactive evaluation and understanding of BSEP inhibition is recommended in drug discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd2fea4f00c01969bbedd865b180a28
https://pubmed.ncbi.nlm.nih.gov/30137645
https://pubmed.ncbi.nlm.nih.gov/30137645
Autor:
Janet Hoogstraate, Johan E. Palm, Jenny M. Pedersen, Per Artursson, Elin K. Khan, Christel A. S. Bergström
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 103
Drug transport and drug-drug interactions (DDI) with human ABC transporters are generally investigated in mammalian cell lines or inverted membrane vesicles from insect cells (Sf9) overexpressing the transporter of interest. In this study, we instead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5d0dd4f02ea8e197c9c2b6639b7b38
https://pubmed.ncbi.nlm.nih.gov/28263911
https://pubmed.ncbi.nlm.nih.gov/28263911
Autor:
Gustav Ahlin, Jenny M. Pedersen, Christel A. S. Bergström, Johan Karlsson, Ulf Norinder, Lena Gustavsson, Pär Matsson, Rolf Larsson, Per Artursson
Publikováno v:
Journal of Medicinal Chemistry. 51:5932-5942
The liver-specific organic cation transport protein (OCT1; SLC22A1) transports several cationic drugs including the antidiabetic drug metformin and the anticancer agents oxaliplatin and imatinib. In this study, we explored the chemical space of regis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30606a7439b75012c5527107b81699e1
https://doi.org/10.1021/jm8003152
https://doi.org/10.1021/jm8003152
Autor:
Janet Hoogstraate, Edward L. LeCluyse, Pär Matsson, Jenny M. Pedersen, Agneta Norén, Christel A. S. Bergström, Per Artursson
Publikováno v:
Toxicological Sciences
A comprehensive analysis was performed to investigate how inhibition of the human bile salt export pump (BSEP/ABCB11) relates to clinically observed drug-induced liver injury (DILI). Inhibition of taurocholate (TA) transport was investigated in BSEP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4e9eda09d3c91c7eea124d20d9c1a4
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204168
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204168
Autor:
Jenny M. Pedersen, David Billings, Pergentino Balbuena, Melvin E. Andersen, Jeffrey M. Macdonald, Jeffrey R. Enders, Harvey J. Clewell, Martin B. Phillips, Miyoung Yoon, J. Shim, E. Burgunder
Publikováno v:
Toxicology Letters. 258:S140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d1e35e8d6975d5c34223bbb7f584493
https://doi.org/10.1016/j.toxlet.2016.06.1546
https://doi.org/10.1016/j.toxlet.2016.06.1546
Autor:
Jenny M. Pedersen, Martin B. Phillips, Erin Burgunder, Melvin E. Andersen, Joseph Shim, Miyoung Yoon, Pergentino Balbuena, Harvey J. Clewell, David Billings, Jeffrey R. Enders, Jeffrey M. Macdonald
Publikováno v:
Toxicology Letters. 258:S31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::976ba86cc0e8512b4901bcfb3f87c307
https://doi.org/10.1016/j.toxlet.2016.06.1219
https://doi.org/10.1016/j.toxlet.2016.06.1219
Publikováno v:
Pharmaceutical research. 26(8)
To study the inhibition patterns of the three major human ABC transporters P-gp (ABCB1), BCRP (ABCG2) and MRP2 (ABCC2), using a dataset of 122 structurally diverse drugs. Inhibition was investigated in cellular and vesicular systems over-expressing s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a358f52b6f406eb4e96b295f08252566
https://pubmed.ncbi.nlm.nih.gov/19421845
https://pubmed.ncbi.nlm.nih.gov/19421845
Autor:
Jenny M. Pedersen, Christel A. S. Bergström, Per Artursson, Janet Hoogstraate, Ulf Norinder, Pär Matsson
Publikováno v:
Journal of medicinal chemistry. 51(11)
The chemical space of registered oral drugs was explored for inhibitors of the human multidrug-resistance associated protein 2 (MRP2; ABCC2), using a data set of 191 structurally diverse drugs and drug-like compounds. The data set included a new refe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8348c4d0c605e011c8e7d8a5c0ba400d
https://pubmed.ncbi.nlm.nih.gov/18457386
https://pubmed.ncbi.nlm.nih.gov/18457386