Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jenny, Wegert"'
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT. MYCN encodes a transcription factor that requires dimerization with
Externí odkaz:
https://doaj.org/article/5c8f2bf2032c400ca1d44e341c610330
Autor:
Pengbo Beck, Barbara Selle, Lukas Madenach, David T.W. Jones, Christian Vokuhl, Apurva Gopisetty, Arash Nabbi, Ines B. Brecht, Martin Ebinger, Jenny Wegert, Norbert Graf, Manfred Gessler, Stefan M. Pfister, Natalie Jäger
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104167- (2022)
Summary: Pediatric renal cell carcinomas (RCC) differ from their adult counterparts not only in histologic subtypes but also in clinical characteristics and outcome. However, the underlying biology is still largely unclear. For this reason, we perfor
Externí odkaz:
https://doaj.org/article/92c8d7472b5b4a918676c0c8fb0e0805
Autor:
Jenny Wegert, Christian Vokuhl, Grace Collord, Martin Del Castillo Velasco-Herrera, Sarah J. Farndon, Charlotte Guzzo, Mette Jorgensen, John Anderson, Olga Slater, Catriona Duncan, Sabrina Bausenwein, Heike Streitenberger, Barbara Ziegler, Rhoikos Furtwängler, Norbert Graf, Michael R. Stratton, Peter J. Campbell, David TW Jones, Christian Koelsche, Stefan M. Pfister, William Mifsud, Neil Sebire, Monika Sparber-Sauer, Ewa Koscielniak, Andreas Rosenwald, Manfred Gessler, Sam Behjati
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-6 (2018)
Soft tissue tumors in infants encompass an overlapping spectrum of diseases posing unique diagnostic and clinical challenges. Here, the authors investigate the genetic basis of cryptogenic congenital mesoblastic nephroma and infantile fibrosarcoma la
Externí odkaz:
https://doaj.org/article/62e3e5d944664e6c8173d5eb54868ff0
Autor:
Kathy Pritchard-Jones, Gordan Vujanic, Chris Jones, Mike Hubank, Ivo Leuschner, Norbert Graf, Jenny Wegert, Manfred Gessler, Neil Sebire, Boo Messahel, Sergey Popov, Tasnim Chagtai, Reem Al-Saadi, Richard D. Williams
Purpose: Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX, and TP53. However, the majority of cases do not harbor mutations in these genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aabcf207397dff234137844acb902ef
https://doi.org/10.1158/1078-0432.c.6519386
https://doi.org/10.1158/1078-0432.c.6519386
Autor:
Micheala A. Aldred, Chris Jones, Vicki Huff, Jeffrey Dome, Paul Grundy, Kathy Pritchard-Jones, Manfred Gessler, Jenny Wegert, Phyllis Harbor, Rachael Natrajan, E. Cristy Ruteshouser, Kylie M. Drake
Supplementary Data from Loss of Heterozygosity at 2q37 in Sporadic Wilms' Tumor: Putative Role for miR-562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660cda499ca9a86e63ef7f8e275906a8
https://doi.org/10.1158/1078-0432.22440630.v1
https://doi.org/10.1158/1078-0432.22440630.v1
Autor:
Micheala A. Aldred, Chris Jones, Vicki Huff, Jeffrey Dome, Paul Grundy, Kathy Pritchard-Jones, Manfred Gessler, Jenny Wegert, Phyllis Harbor, Rachael Natrajan, E. Cristy Ruteshouser, Kylie M. Drake
Purpose: Wilms' tumor is a childhood cancer of the kidney with an incidence of ∼1 in 10,000. Cooccurrence of Wilms' tumor with 2q37 deletion syndrome, an uncommon constitutional chromosome abnormality, has been reported previously in three children
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aac619f78a1cf5567f81a9d8aa5410
https://doi.org/10.1158/1078-0432.c.6517932
https://doi.org/10.1158/1078-0432.c.6517932
Autor:
Kathy Pritchard-Jones, Gordan Vujanic, Chris Jones, Mike Hubank, Ivo Leuschner, Norbert Graf, Jenny Wegert, Manfred Gessler, Neil Sebire, Boo Messahel, Sergey Popov, Tasnim Chagtai, Reem Al-Saadi, Richard D. Williams
Supplementary Data from Subtype-Specific FBXW7 Mutation and MYCN Copy Number Gain in Wilms' Tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594ac882fe908a772d4f2b69b3d98fd1
https://doi.org/10.1158/1078-0432.22442717.v1
https://doi.org/10.1158/1078-0432.22442717.v1
Autor:
Amy L. Walz, Mariana Maschietto, Brian Crompton, Nicholas Evageliou, David Dix, Godelieve Tytgat, Manfred Gessler, David Gisselsson, Najat C. Daw, Jenny Wegert
Publikováno v:
Pediatric Blood & Cancer. 70
The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new possibilities for diagnosis and treatment. In additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88862fbfeca0224b34e9aef59921a1a
https://doi.org/10.1002/pbc.30130
https://doi.org/10.1002/pbc.30130
Autor:
Norbert Graf, Lisa Zauter, Karen Ernestus, Manfred Gessler, Christoph Otto, Christian Vokuhl, Rhoikos Furtwängler, Silke Appenzeller, Sabrina Bausenwein, Jenny Wegert
Publikováno v:
Oncogene
In vitro models represent a critical tool in cancer research to study tumor biology and to evaluate new treatment options. Unfortunately, there are no effective preclinical models available that represent Wilms tumor (WT) — the most common pediatri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d068762e6bee8f53ba7b9283f7fb967b
https://doi.org/10.1038/s41388-019-1027-8
https://doi.org/10.1038/s41388-019-1027-8
Autor:
Nico Gerstner, Manfred Gessler, Hans-Peter Lenhof, Lara Schneider, Ute Distler, Tim Kehl, Eckart Meese, Nicole Ludwig, Jenny Wegert, Stefan Tenzer, Andreas Keller, Daniel Stöckel, Kathrin Kattler, Norbert Graf, Jörn Walter
Publikováno v:
International Journal of Cancer. 144:1432-1443
Wilms tumors are the most common type of pediatric kidney tumors. While the overall prognosis for patients is favorable, especially tumors that exhibit a blastemal subtype after preoperative chemotherapy have a poor prognosis. For an improved risk as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba32504beb70e1d1417899bd1274fe96
https://doi.org/10.1002/ijc.31834
https://doi.org/10.1002/ijc.31834