Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Jenny, Klintman"'
1
Akademický článek
Complement activation negatively affects the platelet response to thrombopoietin receptor agonists in patients with immune thrombocytopenia: a prospective cohort study
Autor: Alexander Åkesson, James B. Bussel, Myriam Martin, Anna M. Blom, Jenny Klintman, Waleed Ghanima, Eva Zetterberg, Lamya Garabet
Publikováno v: Platelets, Vol 34, Iss 1 (2023)
Increased platelet destruction is central in the pathogenesis of immune thrombocytopenia. However, impaired platelet production is also relevant and its significance underlies the rationale for treatment with thrombopoietin receptor agonists (TPO-RAs
Externí odkaz: https://doaj.org/article/4ab880211eae4cfa85a11a3095bac1dc
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2
Akademický článek
Biomarkers of Complement and Platelet Activation are not correlated with the One or Twenty-Four Hours Corrected Count Increments in Prophylactically Platelet Transfused Hematological Patients: a Prospective Cohort Study
Autor: Alexander Åkesson, Marcus Ljungkvist, Myriam Martin, Anna M. Blom, Jenny Klintman, Ulf Schött, Eva Zetterberg, Thomas Kander
Publikováno v: Platelets, Vol 33, Iss 3, Pp 350-359 (2022)
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of
Externí odkaz: https://doaj.org/article/aeb55bbca87c4b1eb6a104d4e605cfd0
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3
Akademický článek
First-line therapy in chronic lymphocytic leukemia: a Swedish nation-wide real-world study on 1053 consecutive patients treated between 2007 and 2013
Autor: Sandra Eketorp Sylvan, Anna Asklid, Hemming Johansson, Jenny Klintman, Jenny Bjellvi, Staffan Tolvgård, Eva Kimby, Stefan Norin, Per-Ola Andersson, Claes Karlsson, Karin Karlsson, Birgitta Lauri, Mattias Mattsson, Anna Bergendahl Sandstedt, Maria Strandberg, Anders Österborg, Lotta Hansson
Publikováno v: Haematologica, Vol 104, Iss 4 (2019)
The aim of this study was to investigate long-term outcome following first-line therapy in consecutive chronic lymphocytic leukemia (CLL) patients in a well-defined geographic area: Sweden. All patients diagnosed with CLL (2007–2013) (n=3672) were
Externí odkaz: https://doaj.org/article/f8ee6428d9824583bdf7bcb653686120
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4
Clinical characterization and identification of rare genetic variants in atypical hemolytic uremic syndrome: A Swedish retrospective observational study
Autor: Alexander Åkesson, Myriam Martin, Anna M. Blom, Eva Zetterberg, Migle Gabrielaite, Jenny Klintman, Maria Rossing
Publikováno v: Åkesson, A, Martin, M, Blom, A M, Rossing, M, Gabrielaite, M, Zetterberg, E & Klintman, J 2021, ' Clinical characterization and identification of rare genetic variants in atypical hemolytic uremic syndrome : A Swedish retrospective observational study ', Therapeutic Apheresis and Dialysis, vol. 25, no. 6, pp. 988-1000 . https://doi.org/10.1111/1744-9987.13634
INTRODUCTION: Complement-mediated atypical hemolytic uremic syndrome (aHUS) is an ultra-rare renal disease primarily caused by genetic alterations in complement proteins. The genetic work-up required for confirmation of diagnosis is complicated and n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28730e69ef57028d332983b0602208f
https://doi.org/10.1111/1744-9987.13634
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5
The prospective Hemophilia Inhibitor PUP Study reveals distinct antibody signatures prior to FVIII inhibitor development
Autor: Amy D. Shapiro, B. Gangadharan, J. Bowen, Christoph Male, Helmut Schweiger, C. J. Hofbauer, Verena Berg, Elena Santagostino, Michael Recht, Margaret V. Ragni, Janice M. Staber, Deborah L Brown, Jenny Klintman, Shannon L. Meeks, Birgit M. Reipert, Karin Fijnvandraat, Hassan M. Yaish, Jan Blatny, Catherine E. McGuinn, Eric S. Mullins, Vlad C. Radulescu
Publikováno v: Blood Adv
Blood advances, 4(22), 5785-5796. American Society of Hematology
Preventing factor VIII (FVIII) inhibitors following replacement therapies with FVIII products in patients with hemophilia A remains an unmet medical need. Better understanding of the early events of evolving FVIII inhibitors is essential for risk ide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681fd965767be44a9de0a71548b5d13f
https://doi.org/10.1182/bloodadvances.2020002731
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6
Bone mineral density in haemophilia – a multicentre study evaluating the impact of different replacement regimens
Autor: Jenny Klintman, Kristina E Akesson, Pål André Holme, Kathelijn Fischer
Aim The aim of this study was to investigate if prophylactic treatment in severe haemophilia impact on bone mineral densisty (BMD) in adults with haemophilia A/B. Methods Subjects with haemophilia (n = 120) underwent bone-density measurement and clin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec566ac78f6158cf894cfa6c00e9e62
http://hdl.handle.net/10852/97720
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7
Biomarkers of Complement and Platelet Activation are not correlated with the One or Twenty-Four Hours Corrected Count Increments in Prophylactically Platelet Transfused Hematological Patients: a Prospective Cohort Study
Autor: Jenny Klintman, Thomas Kander, Ulf Schött, Marcus Ljungkvist, Anna M. Blom, Alexander Åkesson, Myriam Martin, Eva Zetterberg
Publikováno v: Platelets. 33(3)
Platelet transfusion refractoriness is a serious clinical concern that complicates the management of thrombocytopenic patients. Previous studies have suggested a potential role for both complement and platelet activation based on in vitro analyses of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a094c49f35e66065f5b23a2bd1ae37e
https://pubmed.ncbi.nlm.nih.gov/34210243
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8
Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia
Autor: Dimitrios V Vavoulis, Jenny Klintman, Toby A. Eyre, Kate Ridout, Robert Månsson, Samantha J. L. Knight, Anna Schuh, Helene Dreau, Maite Cabes, Jenny C. Taylor, Niamh Appleby, Pauline Robbe, Niko Popitsch, Laura Lopez Pascua, Elias Campo, Mats Ehinger, Iñaki Martin-Subero, Basile Stamatopoulos, Davide Rossi
Publikováno v: Blood, 137 (20
Blood
The transformation of chronic lymphocytic leukemia (CLL) to high-grade B-cell lymphoma is known as Richter syndrome (RS), a rare event with dismal prognosis. In this study, we conducted whole-genome sequencing (WGS) of paired circulating CLL (PB-CLL)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09dcec1ef9f5887f2d5a1cecdfe3387
https://pubmed.ncbi.nlm.nih.gov/34806797
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9
SAMHD1 limits the efficacy of forodesine in leukaemia by protecting cells against cytotoxicity of dGTP
Autor: Jan Rehwinkel, Rachel E. Rigby, Jenny Klintman, Kim De Keersmaecker, Anna Schuh, Andrei Chabes, Anne Bridgeman, Peter Hillmen, Bernadeta Dadonaite, Tamara Davenne, Sushma Sharma, Chiara Cursi
Summary The anti-leukaemia agent forodesine causes cytotoxic overload of intracellular deoxyguanosine triphosphate (dGTP) but is efficacious only in a subset of patients. We report that SAMHD1, a phosphohydrolase degrading deoxyribonucleoside triphos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273fdc4fc542fe240b0e400802e47003
https://doi.org/10.1101/2020.02.17.951517
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