The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia

Autor: Stefan Kurtenbach, Andreas Gießl, Siv Strömberg, Jan Kremers, Jenny Atorf, Sebastian Rasche, Eva M. Neuhaus, Denis Hervé, Johann Helmut Brandstätter, Esther Asan, Hanns Hatt, Manfred W. Kilimann

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)

Abstract BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutati

Externí odkaz: https://doaj.org/article/3f19e8543c154b8eb7ffd756b3258257

Photoreceptor degeneration in two mouse models for congenital stationary night blindness type 2.

Autor: Hanna Regus-Leidig, Jenny Atorf, Andreas Feigenspan, Jan Kremers, Marion A Maw, Johann Helmut Brandstätter

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e86769 (2014)

Light-dependent conductance changes of voltage-gated Cav1.4 channels regulate neurotransmitter release at photoreceptor ribbon synapses. Mutations in the human CACNA1F gene encoding the α1F subunit of Cav1.4 channels cause an incomplete form of X-li

Externí odkaz: https://doaj.org/article/b688b3da90ea4f36ad2ccdd470982b1a

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice

Autor: Frederique Varoqueaux, Jan Kremers, Julia von Wittgenstein, Anneka Joachimsthaler, Benjamin H. Cooper, Johann Helmut Brandstätter, Maike Hemmerlein, Kaspar Gierke, Jenny Atorf, Hanna Regus-Leidig

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7848, p 7848 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 21

Munc13 isoforms are constituents of the presynaptic compartment of chemical synapses, where they govern important steps in preparing synaptic vesicles for exocytosis. The role of Munc13-1, -2 and -3 is well documented in brain neurons, but less is kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b949c479a54c2a24f0b6814ece1d0199
https://www.mdpi.com/1422-0067/21/21/7848

Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses

Autor: Hanna Regus-Leidig, Anneka Joachimsthaler, Andreas Feigenspan, Martina Löhner, Johann Helmut Brandstätter, Kaspar Gierke, Jan Kremers, Susanne Schoch, Jenny Atorf, Tanja M. Müller, Henrik Martens, Angela Peukert, Norbert Babai

Publikováno v: The Journal of Neuroscience. 37:7848-7863

RAB3A-interacting molecule (RIM) proteins are important regulators of transmitter release from active zones. At conventional chemical synapses, RIMs contribute substantially to vesicle priming and docking and their loss reduces the readily releasable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a68f20d5cb4f5b72183eae70e61175
https://doi.org/10.1523/jneurosci.2795-16.2017

The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein Golf to Olfactory Cilia

Autor: Jan Kremers, Hanns Hatt, Esther Asan, Sebastian Rasche, Eva M. Neuhaus, Siv Strömberg, Andreas Gießl, Manfred W. Kilimann, Johann Helmut Brandstätter, Jenny Atorf, Denis Hervé, Stefan Kurtenbach

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7, pp.8409. ⟨10.1038/s41598-017-08543-4⟩
Scientific Reports, 2017, 7, pp.8409. ⟨10.1038/s41598-017-08543-4⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)

BEACH domain proteins are involved in membrane protein traffic and human diseases, but their molecular mechanisms are not understood. The BEACH protein LRBA has been implicated in immune response and cell proliferation, and human LRBA mutations cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af828fb794eba82ac38befa9c5937606
https://doi.org/10.1038/s41598-017-08543-4