Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jennings F, Worley"'
Publikováno v:
SLAS Discovery. 8:50-64
3To address the throughput restrictions of classical patch clamp electrophysiology, Essen Instruments has developed a platebased electrophysiology measurement platform. The instrument is an integrated platform that consists of computer-controlled flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59ee3c30bc0af67f05a3b3ed2b7929c
https://doi.org/10.1177/1087057102239667
https://doi.org/10.1177/1087057102239667
Autor:
Scott H. Allen, Jeffrey L. Pfohl, Claire Townsend, Jim F Truax, Christopher M. Terry, Andrew J. Peat, Robert J. Mertz, Robert L Veasey, Jennings F. Worley, Stephen A. Thomson, Dulce Garrido
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2977-2980
A series of 7-substituted-3-cyclobutylamino-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives has been synthesized and evaluated as K(ATP) channel agonists using the inside-out excised patch clamp technique. The most active compounds were approximate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5e0516315cfda3f6d2c5913059d201
https://doi.org/10.1016/s0960-894x(02)00617-0
https://doi.org/10.1016/s0960-894x(02)00617-0
Autor:
James F. Truax, J. Patrick Condreay, Jennings F. Worley, Christopher J. Apolito, T. A. Kost, Gang An, Jeffrey L. Pfohl
Publikováno v:
Receptors and Channels. 8:99-111
A variety of transfection approaches have been used to deliver plasmids encoding ion channel genes into cells. We have used the baculovirus transduction system, BacMam, to demonstrate transient expression of multi-subunit KATP channels in CHO-K1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c6c702e77a5c196eef4afb362f061f
https://doi.org/10.3109/10606820212396
https://doi.org/10.3109/10606820212396
Autor:
Jennings F. Worley, Martin J. Main
Publikováno v:
Receptors and Channels. 8:269-282
The ability to apply large-scale screening formats to measures of ion channel function offers immense opportunities for drug discovery and academic research. Technologies have been developed over the last several years that now provide the ability to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb5faa071181b29eac08bb27374dbd5
https://doi.org/10.3109/10606820214643
https://doi.org/10.3109/10606820214643
Publikováno v:
Drug Discovery Today. 3:323-332
Voltage-gated ion channels are emerging as a target class of increasing importance to the pharmaceutical industry because of their relevance to a wide variety of diseases in the cardiovascular, CNS and metabolic areas. In the quest to identify novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49be38a41d6dc62186614b8c82dfe464
https://doi.org/10.1016/s1359-6446(98)01199-4
https://doi.org/10.1016/s1359-6446(98)01199-4
Publikováno v:
Current Opinion in Endocrinology and Diabetes. 4:262-271
The critical event in physiologic glucose-stimulated insulin secretion is the rise, often oscillatory, in intracellular Ca2+ concentration. This has been assumed to be derived exclusively from variations in Ca2+ influx through voltage-dependent Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bfec94f9c60acca8a2c5bdf7647fa9f
https://doi.org/10.1097/00060793-199708000-00003
https://doi.org/10.1097/00060793-199708000-00003
Autor:
Robert J. Mertz, Nathaniel T. Blair, W. Ronald Shehee, Sam M. Witherspoon, Michael W. Roe, Jennings F. Worley, Andrey V. Kuznetsov, M S McIntyre, Anshu A. Mittal, Mary E. Lancaster, Sarmila DasGupta, Iain D. Dukes, Louis H. Philipson
Publikováno v:
Journal of Biological Chemistry. 271:32241-32246
Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles to these channels has proved problematic. Using transgenically derived insulinoma cells (βT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d448b89c5d5461486b5e3a12eab4fa7e
https://doi.org/10.1074/jbc.271.50.32241
https://doi.org/10.1074/jbc.271.50.32241
Publikováno v:
Journal of Biological Chemistry. 271:4838-4845
The energy requirements of most cells supplied with glucose are fulfilled by glycolytic and oxidative metabolism, yielding ATP. In pancreatic β-cells, a rise in cytosolic ATP is also a critical signaling event, coupling closure of ATP-sensitive K+ c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b5ab4136f57a868c6aa3dc570f9309f
https://doi.org/10.1074/jbc.271.9.4838
https://doi.org/10.1074/jbc.271.9.4838
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 266:E852-E862
Stimulation of pancreatic islets of Langerhans with glucose results in changes in intracellular Ca2+ concentration ([Ca2+]i). With the use of mouse islets loaded with fura 2, the earliest glucose-induced alteration of [Ca2+]i was a pronounced decline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1075f4e4b68990158e2828f7d5ed79a5
https://doi.org/10.1152/ajpendo.1994.266.6.e852
https://doi.org/10.1152/ajpendo.1994.266.6.e852
Publikováno v:
Journal of Biological Chemistry. 269:14359-14362
Glucose stimulation of islet beta-cell insulin secretion is initiated by membrane depolarization and an elevation in intracellular free calcium concentration ([Ca2+]i) from a combination of influx through depolarization-activated Ca2+ channels and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2cbe536b4a9af840d696f4a4fc7f01
https://doi.org/10.1016/s0021-9258(17)36628-0
https://doi.org/10.1016/s0021-9258(17)36628-0