Výsledky vyhledávání - "Jennilee M. Davidson"

Akademický článek

Cyclin F can alter the turnover of TDP-43

Autor: Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee

Publikováno v: Neurobiology of Disease, Vol 192, Iss , Pp 106421- (2024)

Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43. A hurdle to the use of cyclin F, however, is that th

Externí odkaz: https://doaj.org/article/938a323b072b422dbb397509b51afada

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Akademický článek

TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex

Autor: Stephanie L. Rayner, Shu Yang, Natalie E. Farrawell, Cyril J. Jagaraj, Flora Cheng, Jennilee M. Davidson, Luan Luu, Alberto G. Redondo, Alberto Rábano, Daniel Borrego-Hernández, Julie D. Atkin, Marco Morsch, Ian P. Blair, Justin J. Yerbury, Roger Chung, Albert Lee

Publikováno v: Neurobiology of Disease, Vol 167, Iss , Pp 105673- (2022)

Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. ALS and frontotemporal dementia (FTD) are overlapping diseases with shared p

Externí odkaz: https://doaj.org/article/8b0375252ae3453588b0ea1234e98d29

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Akademický článek

The converging roles of sequestosome-1/p62 in the molecular pathways of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)

Autor: Jennilee M. Davidson, Roger S. Chung, Albert Lee

Publikováno v: Neurobiology of Disease, Vol 166, Iss , Pp 105653- (2022)

Investigations into the pathogenetic mechanisms underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have provided significant insight into the disease. At the cellular level, ALS and FTD are classified as proteinopathies,

Externí odkaz: https://doaj.org/article/2308bff4aca04d7ab283a63ee4159659

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Akademický článek

Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

The past decade has seen a rapid acceleration in the discovery of new genetic causes of ALS, with more than 20 putative ALS-causing genes now cited. These genes encode proteins that cover a diverse range of molecular functions, including free radical

Externí odkaz: https://doaj.org/article/6d9d5478214e4a43b5c90d1b2ff9a16b

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Akademický článek

Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD

Autor: Thomas J. Hedl, Rebecca San Gil, Flora Cheng, Stephanie L. Rayner, Jennilee M. Davidson, Alana De Luca, Maria D. Villalva, Heath Ecroyd, Adam K. Walker, Albert Lee

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are increasing in prevalence but lack targeted therapeutics. Although the pathological mechanisms behind these diseases remain unclear, both ALS

Externí odkaz: https://doaj.org/article/9fb158da4d31476494289e43bada051d

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The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis

Publikováno v: Molecular Neurobiology.

Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis. CCNF encodes for cyclin F, which is part of the cyclin F-E3 ligase complex SCFcyclinF known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e297e94dcdb8abb7f6625ed5a35097
https://doi.org/10.1007/s12035-023-03355-2

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TDP-43 is a ubiquitylation substrate of the SCF

Autor: Stephanie L, Rayner, Shu, Yang, Natalie E, Farrawell, Cyril J, Jagaraj, Flora, Cheng, Jennilee M, Davidson, Luan, Luu, Alberto G, Redondo, Alberto, Rábano, Daniel, Borrego-Hernández, Julie D, Atkin, Marco, Morsch, Ian P, Blair, Justin J, Yerbury, Roger, Chung, Albert, Lee

Publikováno v: Neurobiology of disease. 167

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. ALS and frontotemporal dementia (FTD) are overlapping diseases with shared pathological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2e72d8deb5d2b5daaea902176a491f0e
https://pubmed.ncbi.nlm.nih.gov/35231559

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Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD

Autor: Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Flora Cheng, Luan Luu, Marco Morsch, Ian Blair, Roger Chung, Albert Lee

Publikováno v: The Neuroscientist. :107385842211201

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease and is characterized by the degeneration of upper and lower motor neurons of the brain and spinal cord. ALS is also linked clinically, genetically, and pathologically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384d5f8a60f205846a1848eddd387620
https://doi.org/10.1177/10738584221120182

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