Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jennifer Yoder"'
Autor:
Yun J. Kim, Ellen Sapp, Benjamin G. Cuiffo, Lindsay Sobin, Jennifer Yoder, Kimberly B. Kegel, Zheng-Hong Qin, Peter Detloff, Neil Aronin, Marian DiFiglia
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 346-356 (2006)
N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal proteases. Here, we show that lysosomal proteases, cathepsins D, B and L, affe
Externí odkaz:
https://doaj.org/article/877e860b05cf4a09b15ee4ecb871b503
Autor:
Edith L. Pfister, Neil Aronin, Phillip D. Zamore, Ellen Sapp, Kallanthottathil G. Rajeev, Marian DiFiglia, Meghan B. Sass, Jennifer Yoder, Rajendra K. Pandey, Miguel Sena-Esteves, Dinah W.Y. Sah, Patrick B. Reeves, Muthiah Manoharan, Kathryn Chase
Publikováno v:
Proceedings of the National Academy of Sciences. 104:17204-17209
Huntington's disease (HD) is an autosomal dominant disease caused by a CAG repeat expansion in the Htt gene (1). Mutant Htt causes neuronal death, dementia, and movement dysfunction; there is no effective treatment. In an inducible transgenic mouse m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87780a26ac550d9657075b52f410f20a
https://doi.org/10.1073/pnas.0708285104
https://doi.org/10.1073/pnas.0708285104
Autor:
Ellen Sapp, Kimberly B. Kegel, Neil Aronin, Yun Joong Kim, Marian DiFiglia, Benjamin G. Cuiffo, Peter J. Detloff, Jennifer Yoder, Lindsay Sobin, Zheng-Hong Qin
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 346-356 (2006)
N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal proteases. Here, we show that lysosomal proteases, cathepsins D, B and L, affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d251902599e46e14f71c6eda457bec3
http://www.sciencedirect.com/science/article/pii/S0969996105003177
http://www.sciencedirect.com/science/article/pii/S0969996105003177
Autor:
Leslie M. Thompson, Yumei Wang, Neil Aronin, Marian DiFiglia, Jennifer Yoder, Zheng-Hong Qin, Kimberly B. Kegel, Aleksey G. Kazantsev, Barbara L. Apostol
Publikováno v:
Human Molecular Genetics. 12:3231-3244
The N-terminus of mutant huntingtin (htt) has a polyglutamine expansion and forms neuronal aggregates in the brain of Huntington's disease (HD) patients. Htt expression in vitro activates autophagy, but it is unclear whether autophagic/lysosomal path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d12ab2291b946675827c32240856bc5
https://doi.org/10.1093/hmg/ddg346
https://doi.org/10.1093/hmg/ddg346
Autor:
Yan Wang, Jun Chao Wu, Lin Qi, Zheng-Hong Qin, Marian DiFiglia, Fang Lin, Jennifer Yoder, Kimberly B. Kegel
Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt. PC12 cells and primary cultured brain neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9127f7bcb2ebedabc88d6bbfaffdd5d5
https://europepmc.org/articles/PMC4010368/
https://europepmc.org/articles/PMC4010368/
Autor:
Jennifer Yoder, Lindsay Sobin, Zheng-Hong Qin, Karl D. Bellve, Nicholas Masso, Jonathan Alexander, Kimberly B. Kegel, Ellen Sapp, Kevin E. Fogarty, Xueyi Li, Laryssa A. Comer-Tierney, Miguel Esteves, Clive Standley, Richard A. Tuft, Kathryn Chase, Antonio Valencia, Lawrence M. Lifshitz, Neil Aronin, Marian DiFiglia
Publikováno v:
Molecular and cellular biology. 29(22)
Huntingtin (Htt) localizes to endosomes, but its role in the endocytic pathway is not established. Recently, we found that Htt is important for the activation of Rab11, a GTPase involved in endosomal recycling. Here we studied fibroblasts of healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0a9e251e6e69e71f543dc385840e24
https://pubmed.ncbi.nlm.nih.gov/19752198
https://pubmed.ncbi.nlm.nih.gov/19752198
Autor:
David L. Scott, Jennifer Yoder, G. Isenberg, Benjamin G. Cuiffo, Lindsay Sobin, Marian DiFiglia, Ellen Sapp, Neil Aronin, Zheng-Hong Qin, Yun Joong Kim, Kimberly B. Kegel, Michael R. Hayden, Wolfgang H. Goldmann
Publikováno v:
The Journal of biological chemistry. 280(43)
We have identified a domain in the N terminus of huntingtin that binds to membranes. A three-dimensional homology model of the structure of the binding domain predicts helical HEAT repeats, which emanate a positive electrostatic potential, consistent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f5d4aaecb7d76958ad07e7f1efcb6b
https://pubmed.ncbi.nlm.nih.gov/16085648
https://pubmed.ncbi.nlm.nih.gov/16085648