Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jennifer Y Ge"'
Autor:
Oren J Mechanic, Nathan I Shapiro, David B Gootenberg, Nicholas Kurtzman, Thomas O’Mara, Jennifer Y Ge, David Chiu, Alon Dagan
Publikováno v:
BMJ Health & Care Informatics, Vol 28, Iss 1 (2021)
Objectives Patients with COVID-19 can present to the emergency department (ED) without immediate indication for admission, but with concern for decompensation. Clinical experience has demonstrated that critical illness may present later in the diseas
Externí odkaz:
https://doaj.org/article/17229d2ab393494eaaed3e96dc16abaa
Autor:
Ji Li, Peter S Choi, Christine L Chaffer, Katherine Labella, Justin H Hwang, Andrew O Giacomelli, Jong Wook Kim, Nina Ilic, John G Doench, Seav Huong Ly, Chao Dai, Kimberly Hagel, Andrew L Hong, Ole Gjoerup, Shom Goel, Jennifer Y Ge, David E Root, Jean J Zhao, Angela N Brooks, Robert A Weinberg, William C Hahn
Publikováno v:
eLife, Vol 7 (2018)
Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse functions. In a genome-scale expression screen for inducers of the epithelial-to-mesenchymal
Externí odkaz:
https://doaj.org/article/065b7c78b0bc49f4914d3e34a00422d9
Autor:
Bojana Jovanović, Daniel Temko, Laura E. Stevens, Marco Seehawer, Anne Fassl, Katherine Murphy, Jayati Anand, Kodie Garza, Anushree Gulvady, Xintao Qiu, Nicholas W. Harper, Veerle W. Daniels, Huang Xiao-Yun, Jennifer Y. Ge, Maša Alečković, Jason Pyrdol, Kunihiko Hinohara, Shawn B. Egri, Malvina Papanastasiou, Raga Vadhi, Alba Font-Tello, Robert Witwicki, Guillermo Peluffo, Anne Trinh, Shaokun Shu, Benedetto Diciaccio, Muhammad B. Ekram, Ashim Subedee, Zachary T. Herbert, Kai W. Wucherpfennig, Anthony G. Letai, Jacob D. Jaffe, Piotr Sicinski, Myles Brown, Deborah Dillon, Henry W. Long, Franziska Michor, Kornelia Polyak
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113564- (2023)
Summary: Triple-negative breast cancer (TNBC) is a heterogeneous disease with limited treatment options. To characterize TNBC heterogeneity, we defined transcriptional, epigenetic, and metabolic subtypes and subtype-driving super-enhancers and transc
Externí odkaz:
https://doaj.org/article/5b7a46fb42fa443eac6a172b0b60048f
Autor:
Jennifer Y. Ge, Shaokun Shu, Mijung Kwon, Bojana Jovanović, Katherine Murphy, Anushree Gulvady, Anne Fassl, Anne Trinh, Yanan Kuang, Grace A. Heavey, Adrienne Luoma, Cloud Paweletz, Aaron R. Thorner, Kai W. Wucherpfennig, Jun Qi, Myles Brown, Piotr Sicinski, Thomas O. McDonald, David Pellman, Franziska Michor, Kornelia Polyak
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Effective combination therapies to improve the efficacy of BET inhibitors are currently under investigation. Here, the authors examine palbociclib and paclitaxel as two promising candidates for combination therapies with BET inhibition in breast canc
Externí odkaz:
https://doaj.org/article/c6750e9707894301940edb49bbf81051
Autor:
Beth Overmoyer, Jennifer Y Ge
Publikováno v:
Case Reports in Oncology, Vol 14, Iss 2, Pp 1071-1079 (2021)
Case Reports in Oncology
Case Reports in Oncology
Inflammatory breast cancer (IBC) is a rare type of breast cancer that is associated with poor outcomes compared with non-IBC. Overexpression of HER2 is enriched in IBC, and those with HER2-positive disease have a relatively favorable prognosis, with
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 9, Iss 4, Pp 1175-1188 (2019)
G3: Genes, Genomes, Genetics, Vol 9, Iss 4, Pp 1175-1188 (2019)
Mitochondrial DNA (mtDNA) has been one of the most extensively studied molecules in ecological, evolutionary and clinical genetics. In its early application in evolutionary genetics, mtDNA was assumed to be a selectively neutral marker conferring neg
Publikováno v:
IUBMB Life. 70:1275-1288
Mitochondrial function requires the coordinated expression of dozens of gene products from the mitochondrial genome and hundreds from the nuclear genomes. The systems that emerge from these interactions convert the food we eat and the oxygen we breat
Autor:
Bojana Jovanovic, Kornelia Polyak, Anushree C. Gulvady, Tom O. McDonald, David Pellman, Aaron R. Thorner, Kai W. Wucherpfennig, Katherine Murphy, Anne Fassl, Mijung Kwon, Piotr Sicinski, Anne Trinh, Cloud P. Paweletz, Shaokun Shu, Adrienne M. Luoma, Franziska Michor, Yanan Kuang, Jun Qi, Myles Brown, Jennifer Y Ge, Grace A. Heavey
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
BET inhibitors are promising therapeutic agents for the treatment of triple-negative breast cancer (TNBC), but the rapid emergence of resistance necessitates investigation of combination therapies and their effects on tumor evolution. Here, we show t
Autor:
David B. Gootenberg, Thomas A O'Mara, Oren J. Mechanic, Nicholas Kurtzman, Alon Dagan, Nathan I. Shapiro, Jennifer Y Ge, David Chiu
Publikováno v:
BMJ Health & Care Informatics, Vol 28, Iss 1 (2021)
BMJ Health & Care Informatics
BMJ Health & Care Informatics
ObjectivesPatients with COVID-19 can present to the emergency department (ED) without immediate indication for admission, but with concern for decompensation. Clinical experience has demonstrated that critical illness may present later in the disease
Autor:
Paloma Cejas, Jayati Anand, Jason S. Carroll, James E. Bradner, Tom O. McDonald, Sudeepa Syamala, Xintao Qiu, Evangelia K. Papachristou, Katherine Murphy, Hua-Jun Wu, Isaac S. Harris, Alba Font-Tello, Joan S. Brugge, Kornelia Polyak, X. Shirley Liu, Klothilda Lim, Cigall Kadoch, Jaime M. Reyes, Tengfei Xiao, Quang-Dé Nguyen, Kai W. Wucherpfennig, Rhamy Zeid, Brittany C. Michel, Clive D'Santos, Myles Brown, Wei Li, Adrienne M. Luoma, Binbin Wang, Jennifer Y Ge, Kunihiko Hinohara, Jennifer E. Endress, Jacob D. Jaffe, Chandra Sekhar Reddy Chilamakuri, Shaokun Shu, Jun Qi, Rebecca Modiste, Bojana Jovanovic, Franziska Michor, Henry W. Long
Publikováno v:
Molecular Cell. 78:1096-1113.e8
BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs limits their potential clinical use. Using CRISPR and small-molecule in