High-throughput prediction of protein conformational distributions with subsampled AlphaFold2

Autor: Gabriel Monteiro da Silva, Jennifer Y. Cui, David C. Dalgarno, George P. Lisi, Brenda M. Rubenstein

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract This paper presents an innovative approach for predicting the relative populations of protein conformations using AlphaFold 2, an AI-powered method that has revolutionized biology by enabling the accurate prediction of protein structures. Wh

Externí odkaz: https://doaj.org/article/7f2e13d81e424a5eb5b8c27b36adc5cd

Molecular Level Insights Into the Structural and Dynamic Factors Driving Cytokine Function

Autor: Jennifer Y. Cui, George P. Lisi

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

Cytokines are key mediators of cellular communication and regulators of biological advents. The timing, quantity and localization of cytokines are key features in producing specific biological outcomes, and thus have been thoroughly studied and revie

Externí odkaz: https://doaj.org/article/d00bda21fc574191a4b4792d3efca812

Hepatic steatosis and reduction in steatosis following bariatric weight loss surgery differs between segments and lobes

Autor: Claude B. Sirlin, Cheng William Hong, Ethan Z. Sy, Jennifer Y Cui, Scott B. Reeder, Kathryn J. Fowler, Soudabeh Fazeli Dehkordy, Alexandra Schlein, Tanya Wolfson, Gavin Hamilton, Anthony Gamst, Yesenia Covarrubias, Adrija Mamidipalli, Jonathan Hooker

Publikováno v: Fazeli Dehkordy, Soudabeh; Fowler, Kathryn J; Mamidipalli, Adrija; Wolfson, Tanya; Hong, Cheng William; Covarrubias, Yesenia; et al.(2018). Hepatic steatosis and reduction in steatosis following bariatric weight loss surgery differs between segments and lobes.. European radiology. doi: 10.1007/s00330-018-5894-0. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4kq0j6qh
Eur Radiol
European radiology, vol 29, iss 5

The purpose of this study was to (1) evaluate proton density fat fraction (PDFF) distribution across liver segments at baseline and (2) compare longitudinal segmental PDFF changes across time points in adult patients undergoing a very low-calorie die

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2d6a0a99218dee6f56dbe02d1f3a9
https://doi.org/10.1007/s00330-018-5894-0

NMR and computational methods for molecular resolution of allosteric pathways in enzyme complexes

Autor: Kyle W. East, Brandon P. Mitchell, George P. Lisi, Rohaine V. Hsu, Jennifer Y. Cui, Erin Skeens, Giulia Palermo, Helen B. Belato, Victor S. Batista

Publikováno v: Biophysical reviews, vol 12, iss 1

Allostery is a ubiquitous biological mechanism in which a distant binding site is coupled to and drastically alters the function of a catalytic site in a protein. Allostery provides a high level of spatial and temporal control of the integrity and ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0093e129a6d64f4984a78171729ebb9
https://pubmed.ncbi.nlm.nih.gov/31838649

Hepatocarcinogenesis and LI-RADS

Autor: Kazim H. Narsinh, Demetri Papadatos, Claude B. Sirlin, Jennifer Y Cui, Cynthia Santillan

Publikováno v: Abdominal radiology (New York), vol 43, iss 1
Narsinh, KH; Cui, J; Papadatos, D; Sirlin, CB; & Santillan, CS. (2018). Hepatocarcinogenesis and LI-RADS. ABDOMINAL RADIOLOGY, 43(1), 158-168. doi: 10.1007/s00261-017-1409-8. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2568p2j2

Hepatocarcinogenesis is a multi-step process characterized by progressive cellular and molecular dedifferentiation of hepatocytes and culminating in the emergence of hepatocellular carcinoma (HCC). Knowledge of hepatocarcinogenesis is important becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f5d61c88c3fee61683365efe29dbae
https://escholarship.org/uc/item/2568p2j2