Efficacy of (S)-lacosamide in preclinical models of cephalic pain

Autor: Aubin Moutal, Nathan Eyde, Edwin Telemi, Ki Duk Park, Jennifer Y. Xie, David W. Dodick, Frank Porreca, Rajesh Khanna

Publikováno v: PAIN Reports, Vol 1, Iss 1, p e565 (2016)

Abstract. Migraine is one of the world's most common neurological disorders. Current acute migraine treatments have suboptimal efficacy, and new therapeutic options are needed. Approaches targeting calcitonin gene related peptide (CGRP) signaling are

Externí odkaz: https://doaj.org/article/b76fbad023a2448786fef6d6f182ed96

Inhibition of experimental visceral pain in rodents by cebranopadol

Autor: Stefanie Frosch, Frank Porreca, Wolfgang P. Schröder, Klaus Schiene, Jennifer Y. Xie, Thomas Christoph, Klaus Linz, Thomas M. Tzschentke

Publikováno v: Behavioural Pharmacology. 30:320-326

The aim of this study was to investigate the efficacy of cebranopadol in two rodent models of visceral pain. Cebranopadol is a first-in-class analgesic with agonist activity at the nociceptin/orphanin FQ opioid peptide receptor and classical µ-, δ-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09deb29feaabd714fd99688df37e2ba5
https://doi.org/10.1097/fbp.0000000000000420

Erratum for the Research Article: 'The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females' by Y. Chen, A. Moutal, E. Navratilova, C. Kopruszinski, X. Yue, M. Ikegami, M. Chow, I. Kanazawa, S. S. Bellampalli, J. Xie, A. Patwardhan, K. Rice, H. Fields, A. Akopian, V. Neugebauer, D. Dodick, R. Khanna, F. Porreca

Autor: Jennifer Y. Xie, Rajesh Khanna, Caroline M. Kopruszinski, Iori Kanazawa, Kenner C. Rice, Megumi Ikegami, Frank Porreca, Shreya S. Bellampalli, Aubin Moutal, Yanxia Chen, David W. Dodick, Armen N. Akopian, M. Chow, Edita Navratilova, Xu Yue, Amol M. Patwardhan, Howard L. Fields, Volker Neugebauer

Publikováno v: Sci Transl Med

Pain is more prevalent in women for reasons that remain unclear. We have identified a mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) promoted by prolactin (PRL) in females. PRL signals through mutually inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed400c8432049af610079745ba723f1f
https://doi.org/10.1126/scitranslmed.abb4549

Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion

Autor: Guo-Lei Zhou, Auburn Ramsey, Uddhab Karki, Yitong Xiao, Haitao Zhang, Jianfeng Xu, Thomas J. Kelly, Shoichiro Ono, Jennifer Y. Xie

Publikováno v: Mol Cell Biol

C yclase- a ssociated p rotein 1 (CAP1) is a conserved actin-regulating protein that enhances actin filament dynamics and also regulates adhesion in mammalian cells. We previously found that phosphorylation at the Ser307/Ser309 tandem site controls i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cfef9dd834a8c4ecf2b31277062e7b
https://europepmc.org/articles/PMC6996279/

Functionalized Nanocellulose Drives Neural Stem Cells toward Neuronal Differentiation

Autor: Malathi Srivatsan, Bijay P. Chhetri, Krishna Deo Sharma, Charlette M. Parnell, Anindya Ghosh, Jennifer Y. Xie, Sahitya Chetan Pandanaboina, Ambar B. RanguMagar

Publikováno v: Journal of Functional Biomaterials
Journal of Functional Biomaterials; Volume 12; Issue 4; Pages: 64
Journal of Functional Biomaterials, Vol 12, Iss 64, p 64 (2021)

Transplantation of differentiated and fully functional neurons may be a better therapeutic option for the cure of neurodegenerative disorders and brain injuries than direct grafting of neural stem cells (NSCs) that are potentially tumorigenic. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8d63c01d20320961eb882230c0ceb3
https://doi.org/10.3390/jfb12040064