Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jennifer X. Wang"'
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
In addition to scavenging exogenous cholesterol, the parasitic kinetoplastid Trypanosoma cruzi can endogenously synthesize sterols. Similar to fungal species, T. cruzi synthesizes ergostane type sterols and is sensitive to a class of azole inhibitors
Externí odkaz:
https://doaj.org/article/489a9ca5a7ea46449e6eb237f53e34f6
Autor:
Kristin R. Wildsmith, Jacob M. Basak, Bruce W. Patterson, Yuriy Pyatkivskyy, Jungsu Kim, Kevin E. Yarasheski, Jennifer X. Wang, Kwasi G. Mawuenyega, Hong Jiang, Maia Parsadanian, Hyejin Yoon, Tom Kasten, Wendy C. Sigurdson, Chengjie Xiong, Alison Goate, David M. Holtzman, Randall J. Bateman
Publikováno v:
PLoS ONE, Vol 7, Iss 7 (2012)
Externí odkaz:
https://doaj.org/article/a8ec821c68c24b83a9e190c8dd65f3ec
Autor:
Christine R. Zheng, Tai L. Ng, Kelvin J. Y. Wu, Monica E. McCallum, Jennifer X. Wang, Emily P. Balskus
Publikováno v:
Chembiochem
N-Nitroso-containing natural products are bioactive metabolites with antibacterial and anticancer properties. In particular, compounds containing the diazeniumdiolate (N-nitrosohydroxylamine) group display a wide range of bioactivities ranging from c
Publikováno v:
eLife, Vol 9 (2020)
The mechanisms underlying resistance of the Chagas disease parasite, Trypanosoma cruzi, to current therapies are not well understood, including the role of metabolic heterogeneity. We found that limiting exogenous glutamine protects actively dividing
Publikováno v:
Dermatitis : contact, atopic, occupational, drug. 31(4)
The mechanisms underlying resistance of the Chagas disease parasite,Trypanosoma cruzi,to current therapies are not well understood, including the potential role of metabolic heterogeneity in modulating susceptibility of intracellular amastigotes to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1f3a58cb94a79f3d91f79b434612e8
https://doi.org/10.1101/2020.06.19.161638
https://doi.org/10.1101/2020.06.19.161638
Publikováno v:
eLife
The mechanisms underlying resistance of the Chagas disease parasite, Trypanosoma cruzi, to current therapies are not well understood, including the role of metabolic heterogeneity. We found that limiting exogenous glutamine protects actively dividing
Autor:
Stephania M. Irwin, Christopher D. Dawson, Jennifer X. Wang, Heather J. Kulik, Emily P. Balskus, Vyshnavi Vennelakanti, Chip Le, Catherine L. Drennan, Zhongyue Yang, Lindsey R. F. Backman
Publikováno v:
Cell Chemical Biology
Summary Desulfonation of isethionate by the bacterial glycyl radical enzyme (GRE) isethionate sulfite-lyase (IslA) generates sulfite, a substrate for respiration that in turn produces the disease-associated metabolite hydrogen sulfide. Here, we prese
Autor:
Michelle Lai, Hye Lim Noh, Jason K. Kim, Jennifer X. Wang, Misung Kim, Sunia A. Trauger, Hee Joon Kang, John K. Meissen, Alan J. Fowler, Ludivine Doridot, Matthew Blatnik, Sarah A. Krawczyk, Mark A. Herman
Publikováno v:
Journal of Clinical Investigation. 126:4372-4386
Obese, insulin-resistant states are characterized by a paradoxical pathogenic condition in which the liver appears to be selectively insulin resistant. Specifically, insulin fails to suppress glucose production, yet successfully stimulates de novo li