Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jennifer Winton"'
Evaluation of the Effect of Ritlecitinib on the Pharmacokinetics of Caffeine in Healthy Participants
Autor:
Liu Jian, Rohit Solan, Robert Wolk, Anna Plotka, Melissa O’Gorman, Jennifer Winton, Julia Kaplan, Vivek Purohit
Objective: This clinical study was conducted to evaluate the impact of ritlecitinib on the pharmacokinetics (PK) of caffeine, a cytochrome P450 1A2 (CYP1A2) substrate. Methods: In this single-center, single-arm, open-label, fixed-sequence study, heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e951cba95f9699c15c9b5a22050e1e94
https://doi.org/10.22541/au.166645623.32214629/v1
https://doi.org/10.22541/au.166645623.32214629/v1
Autor:
Tong Zhu, Sylvester Pawlak, Sima S. Toussi, Frances Hackman, Kimberly Thompson, Wei Song, Joanne Salageanu, Erica Winter, Haihong Shi, Jennifer Winton, Michael Binks
Publikováno v:
Clinical pharmacology in drug developmentReferences. 11(12)
Studies on targeted antivirals for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the ongoing pandemic, are limited. PF-07304814 (lufotrelvir) is the phosphate prodrug of PF-00835231, a protease inhibitor targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e93420f13b1ffa2c5f2aad799f91e80
https://pubmed.ncbi.nlm.nih.gov/36285536
https://pubmed.ncbi.nlm.nih.gov/36285536
Autor:
Hongying Gao, Jennifer A. Young, Joel R. Hardink, Veerabahu Shanmugasundaram, Steven M. Finegan, David Pattavina, Joel T. Arcari, Jian Lin, Jianmin Sun, Mark J. Mitton-Fry, Thuy Hoang, Matthew Frank Brown, Hud Lawrence Risley, Rebecca Irvine, Mark Edward Flanagan, Brandon P. Schuff, Seungil Han, Manjinder S. Lall, Brian S. Gerstenberger, Mark Niosi, Thomas M. Harris, Michael D. Huband, Chao Li, Lisa Mullins, Sandra P. McCurdy, M. Megan Lemmon, John P. Mueller, Jennifer Winton, Jeffrey M. Casavant, Mark S. Plummer, Mark C. Noe, Joseph Penzien, Jeremy T. Starr, David M. George
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5989-5994
Novel siderophore-linked monobactams with in vitro and in vivo anti-microbial activity against MDR Gram-negative pathogens are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f098206894352a3aaa930374bca05a
https://doi.org/10.1016/j.bmcl.2012.07.005
https://doi.org/10.1016/j.bmcl.2012.07.005
Autor:
John P. Mueller, Alvin L. Crumbliss, Majinder Lall, Mark Edward Flanagan, John P. O'Donnell, Tom Gootz, Jennifer Winton, James M. Harrington
Publikováno v:
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 25(5)
The aqueous solution equilibria of a β-lactam antimicrobial agent containing a 3-hydroxy, 4-pyridinone group (L (PF)) binding to Fe(III) in aqueous solution has been characterized through spectrophotometric and potentiometric titrations. The metal-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857acfbdf77c067e85af9919f983e37f
https://pubmed.ncbi.nlm.nih.gov/22855208
https://pubmed.ncbi.nlm.nih.gov/22855208
Autor:
Chao Li, Mark S. Plummer, Veerabahu Shanmugasundaram, Thuy Hoang, Seungil Han, Lisa Mullins, Jennifer A. Young, Mark C. Noe, Thomas M. Harris, Steven M. Finegan, John P. Mueller, Joel R. Hardink, Jian Lin, Joel T. Arcari, Hongying Gao, Jennifer Winton, Manjinder S. Lall, Jeffrey M. Casavant, Jianmin Sun, Hud Lawrence Risley, Mark Edward Flanagan, Joseph Penzien, Brandon P. Schuff, Mark Niosi, Brian S. Gerstenberger, Mark J. Mitton-Fry, Jeremy T. Starr, Rebecca Irvine, David M. George, Matthew Frank Brown, M. Megan Lemmon, Sandra P. McCurdy, Michael D. Huband, David Pattavina
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4029
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a53f51893ca698c746dc3e573386cb2e
https://doi.org/10.1016/j.bmcl.2015.07.024
https://doi.org/10.1016/j.bmcl.2015.07.024