Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jennifer Whitsett"'
Autor:
Galen M. Pieper, Brian Bennett, Irina A. Ionova, Savitha Sethumadhavan, Jeannette Vasquez-Vivar, Jennifer Whitsett
Publikováno v:
Free Radical Biology and Medicine. 93:1-11
Tetrahydrobiopterin (BH4) represents a potential strategy for the treatment of cardiac remodeling, fibrosis and/or diastolic dysfunction. The effects of oral treatment with BH4 (Sapropterin™ or Kuvan™) are however dose-limiting with high dose neg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d55b94c95337705f774277e001559b50
https://doi.org/10.1016/j.freeradbiomed.2016.01.019
https://doi.org/10.1016/j.freeradbiomed.2016.01.019
Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling
Autor:
Jeannette Vasquez-Vivar, Joanna Celinska, Savitha Sethumadhavan, Artur Rangel Filho, Jennifer Whitsett, Michael E. Widlansky
Publikováno v:
Free Radical Biology and Medicine. 63:143-150
Tetrahydrobiopterin (BH4) is required for NO synthesis and inhibition of superoxide release from endothelial NO synthase. Clinical trials using BH4 to treat endothelial dysfunction have produced mixed results. Poor outcomes may be explained by the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559c7d898d72378b4490d7e1ecc653b3
Publikováno v:
Free Radical Biology and Medicine. 51:2300-2308
Primary cytomegalovirus (CMV) infection promotes oxidative stress and reduces nitric oxide (NO) bioavailability in endothelial cells. These events are among the earliest vascular responses to cardiovascular risk factors. We assessed the roles of NAD(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd0dcfcdb6174139181acbab7c2b335
https://doi.org/10.1016/j.freeradbiomed.2011.09.039
https://doi.org/10.1016/j.freeradbiomed.2011.09.039
Autor:
Jennifer Whitsett, Haitao Ji, Jeannette Vasquez-Vivar, Richard B. Silverman, Lei Yu, Matthew Derrick, Sidhartha Tan
Publikováno v:
Developmental Neuroscience. 33:312-319
Cerebral palsy and death are serious consequences of perinatal hypoxia-ischemia (HI). Important concepts can now be tested using an animal model of cerebral palsy. We have previously shown that reactive oxygen and nitrogen species are produced in ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e1a9c86ce5017082ed2fc91fa3d607
https://doi.org/10.1159/000327244
https://doi.org/10.1159/000327244
Autor:
Jeannette Vasquez-Vivar, Lei Yu, Sidhartha Tan, Xinhai Ji, Jennifer Whitsett, Matthew Derrick
Publikováno v:
Annals of Neurology. 66:323-331
Objective: Tetrahydrobiopterin (BH4) deficiency is one of the causes of dystonia at birth. We hypothesized that BH4 is a developmental factor determining vulnerability of the immature fetal brain to hypoxic-ischemic injury and subsequent motor defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38c56be576c7e8f8090d1764f4322c0e
https://doi.org/10.1002/ana.21738
https://doi.org/10.1002/ana.21738
Autor:
Meetha Medhora, Jeannette Vasquez-Vivar, Irina A. Ionova, Galen M. Pieper, Jennifer Whitsett, Anja Herrnreiter, Brian C. Cooley
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 295:H2178-H2187
Adult rat cardiac myocytes typically display a phenotypic response to cytokines manifested by low or no increases in nitric oxide (NO) production via inducible NO synthase (iNOS) that distinguishes them from other cell types. To better characterize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6662052279b1d4b48219144bcb54db
https://doi.org/10.1152/ajpheart.00748.2008
https://doi.org/10.1152/ajpheart.00748.2008
Autor:
Jeannette Vasquez-Vivar, Balaraman Kalyanaraman, Eugene A. Konorev, Irina A. Ionova, Jacek Zielonka, Jennifer Whitsett, Yang Shi, Galen M. Pieper
Publikováno v:
Free Radical Biology and Medicine. 45:994-1001
There is evidence that nitric oxide (NO) formation in adult cardiomyocytes stimulated with lipopolysaccharide (LPS) is not commensurate with iNOS levels. Tetrahydrobiopterin (BH(4)) is a key factor in the stabilization and NO production by iNOS homod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9531a612b8cf4f6b3d1f0fbcd3b36d9
https://doi.org/10.1016/j.freeradbiomed.2008.06.017
https://doi.org/10.1016/j.freeradbiomed.2008.06.017
Autor:
Jeannette Vasquez-Vivar, Balaraman Kalyanaraman, Jennifer Whitsett, Eugene A. Konorev, Kazuyuki Hatakeyama, Shasi V. Kalivendi
Publikováno v:
Free Radical Biology and Medicine. 38:481-491
Alterations in tetrahydrobiopterin (BH4) levels have significant consequences in vascular pathophysiology. However, the mechanisms regulating BH4 remain poorly understood. The activity of GTP cyclohydrolase I (GTPCH-I), the first enzyme in BH4 biosyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c62ce53c0f4a8749a8bd8ea3fea76b
https://doi.org/10.1016/j.freeradbiomed.2004.11.004
https://doi.org/10.1016/j.freeradbiomed.2004.11.004
Autor:
Damon Duquaine, Balaraman Kalyanaraman, Jeannette Vasquez-Vivar, Jennifer Whitsett, Sanjay Rajagopalan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 22:1655-1661
Objective— Tetrahydrobiopterin (BH 4 ) is of fundamental importance for the normal function of endothelial NO synthase. The purpose of this study was to investigate the effects of hyperlipidemia on vascular BH 4 levels and the effect of supplementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb659acd8293abd1b974c16c405be88
https://doi.org/10.1161/01.atv.0000029122.79665.d9
https://doi.org/10.1161/01.atv.0000029122.79665.d9
Autor:
Jeannette VÁSQUEZ-VIVAR, Pavel MARTÁSEK, Jennifer WHITSETT, Joy JOSEPH, Balaraman KALYANARAMAN
Publikováno v:
Biochemical Journal. 362:733-739
Augmentation of superoxide levels has been linked to impaired relaxation in hypertension, diabetes and hypercholesterolaemia. Purified endothelial nitric oxide synthase (eNOS) generates superoxide under limited availability of 5,6,7,8-tetrahydrobiopt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7583e5370731b33e1e073e764316b849
https://doi.org/10.1042/bj3620733
https://doi.org/10.1042/bj3620733