Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jennifer W. Lou"'
Autor:
Elnaz Khalili Samani, Amy C. Chen, Jennifer W. Lou, David L. Dai, Alexander F. A. Keszei, Guihong Tan, Charles Boone, Martin Grininger, Mohammad T. Mazhab-Jafari
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes. In fungi, FAS forms a 2.6 MDa symmetric assembly with six identical copies of FAS
Externí odkaz:
https://doaj.org/article/426835cd27af4b18b2741bd4d0b37a91
Autor:
S. M. Naimul Hasan, Jennifer W. Lou, Alexander F. A. Keszei, David L. Dai, Mohammad T. Mazhab-Jafari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a 16-carbon chain fatty acid that is the primary precursor of lipid metabolism and an important intracellular signaling molecule. FASN is an attractive drug target in d
Externí odkaz:
https://doaj.org/article/8feb1bdab32e4d7d8e92197eddf1190f
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
During fatty acid biosynthesis, acyl carrier proteins (ACPs) from type I fungal fatty acid synthase (FAS) shuttle substrates and intermediates within a reaction chamber that hosts multiple spatially-fixed catalytic centers. A major challenge in under
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
The acyl carrier protein (ACP) domain shuttles substrates and reaction intermediates in type I fungal fatty acid synthases via transient protein-protein interactions. Here, using electron cryo-microscopy (cryoEM), we report the structure of a fungal