Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jennifer W. Lou"'
Autor:
Elnaz Khalili Samani, Amy C. Chen, Jennifer W. Lou, David L. Dai, Alexander F. A. Keszei, Guihong Tan, Charles Boone, Martin Grininger, Mohammad T. Mazhab-Jafari
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Acyl carrier protein (ACP) is the work horse of polyketide (PKS) and fatty acid synthases (FAS) and acts as a substrate shuttling domain in these mega enzymes. In fungi, FAS forms a 2.6 MDa symmetric assembly with six identical copies of FAS
Externí odkaz:
https://doaj.org/article/426835cd27af4b18b2741bd4d0b37a91
Autor:
S. M. Naimul Hasan, Jennifer W. Lou, Alexander F. A. Keszei, David L. Dai, Mohammad T. Mazhab-Jafari
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a 16-carbon chain fatty acid that is the primary precursor of lipid metabolism and an important intracellular signaling molecule. FASN is an attractive drug target in d
Externí odkaz:
https://doaj.org/article/8feb1bdab32e4d7d8e92197eddf1190f
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
During fatty acid biosynthesis, acyl carrier proteins (ACPs) from type I fungal fatty acid synthase (FAS) shuttle substrates and intermediates within a reaction chamber that hosts multiple spatially-fixed catalytic centers. A major challenge in under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c80d37c88f9f267244a7fbf776f0836
http://link.springer.com/article/10.1038/s41598-019-49261-3
http://link.springer.com/article/10.1038/s41598-019-49261-3
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-9 (2020)
The acyl carrier protein (ACP) domain shuttles substrates and reaction intermediates in type I fungal fatty acid synthases via transient protein-protein interactions. Here, using electron cryo-microscopy (cryoEM), we report the structure of a fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3d71a71f55dc4ce18daf49c868f72c
https://pubmed.ncbi.nlm.nih.gov/32471977
https://pubmed.ncbi.nlm.nih.gov/32471977
Autor:
Samani, Elnaz Khalili1 (AUTHOR), Chen, Amy C.1 (AUTHOR), Lou, Jennifer W.1 (AUTHOR), Dai, David L.1 (AUTHOR), Keszei, Alexander F. A.1,2 (AUTHOR), Tan, Guihong3 (AUTHOR), Boone, Charles3,4 (AUTHOR), Grininger, Martin5 (AUTHOR), Mazhab-Jafari, Mohammad T.1,2 (AUTHOR) mohammad.mazhabjafari@utoronto.ca
Publikováno v:
Communications Biology. 1/12/2024, Vol. 7 Issue 1, p1-10. 10p.
Autor:
Lou, Jennifer W.1,2, Mazhab-Jafari, Mohammad T.1,2 Mohammad.Mazhab-Jafari@uhnresearch.ca
Publikováno v:
Communications Biology. 5/29/2020, Vol. 3 Issue 1, p1-9. 9p.
Autor:
Hasan, S. M. Naimul, Lou, Jennifer W., Keszei, Alexander F. A., Dai, David L., Mazhab-Jafari, Mohammad T.
Publikováno v:
Nature Communications; 6/12/2023, Vol. 14 Issue 1, p1-10, 10p
Autor:
Lou, Jennifer W.1, Iyer, Kali R.2, Hasan, S. M. Naimul1, Cowen, Leah E.2, Mazhab-Jafari, Mohammad T.1 Mohammad.Mazhab-Jafari@uhnresearch.ca
Publikováno v:
Scientific Reports. 9/10/2019, Vol. 9 Issue 1, pN.PAG-N.PAG. 1p.
Publikováno v:
Drug Week; 7/7/2023, p1400-1400, 1p